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Application of a kind of heparin analog in preparation of medicine for treating or preventing acute pancreatitis

A technology for acute pancreatitis and its analogues, which is applied in the field of application of heparin analogues in the preparation of drugs for the treatment or prevention of acute pancreatitis, which can solve problems such as massive bleeding, achieve the goal of removing anticoagulation, improving safety, and maintaining effectiveness Effect

Active Publication Date: 2022-03-01
JIANGNAN UNIV
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Problems solved by technology

However, because low molecular weight heparin has the function of anticoagulation, it often has the risk of massive bleeding when used clinically.

Method used

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  • Application of a kind of heparin analog in preparation of medicine for treating or preventing acute pancreatitis
  • Application of a kind of heparin analog in preparation of medicine for treating or preventing acute pancreatitis
  • Application of a kind of heparin analog in preparation of medicine for treating or preventing acute pancreatitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0036] (1) Preparation of non-anticoagulant heparin by derivatization method

[0037] 1. Preparation of Heparin Pyridinium Salt

[0038] Take 40mL of cation exchange resin and wash it three times with deionized water, weigh 10g of refined heparin sodium and dissolve it in 80mL of deionized water, add it to the resin after pre-cooling at 4°C, shake at 210rpm for 40min on a shaker at 4°C. The supernatant was taken, placed on ice, and the resin was washed with water (three times) until the pH was neutral. Finally, the total volume was approximately 500 mL, and about 6 mL of pyridine was added on ice to adjust the pH to neutral, and then freeze-dried to obtain heparin pyridine salt.

[0039] 2. Preparation of Partially Desulfated Heparin

[0040] Weigh 2g of heparin pyridine salt and add 200mL of anhydrous pyridine, fill with N2 and stir to dissolve, add 20mL of MTSTFA and fill with nitrogen, heat in an oil bath at 110°C for 2.5h, and then start rotary evaporation. After rotary...

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Abstract

The invention provides the application of a heparin analogue in the preparation of medicines for treating or preventing acute pancreatitis, and belongs to the technical field of biomedical materials. The heparin analogue is 6-desulfated heparin or N, O-acetylated heparin, which can effectively remove the anticoagulant effect. In the whole animal experiment, the anti-pancreatitis effect is retained, so the safety is greatly improved. While maintaining the effectiveness of the drug.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to the application of a heparin analogue in the preparation of medicines for treating or preventing acute pancreatitis. Background technique [0002] Acute pancreatitis (AP) is a common critical disease of the digestive system, which is caused by the autodigestion of pancreatic tissue after the activation of pancreatic enzymes in the pancreas. Syndrome, seriously endangering the life of the patient. In recent years, the incidence of acute pancreatitis in my country has been increasing year by year, and the overall mortality rate of acute pancreatitis is as high as 5%. Studies have shown that the pathogenesis of acute pancreatitis mainly includes obesity, hyperlipidemia, inflammatory response caused by excessive activation of leukocytes, pancreatic microcirculation disturbance, and inflammatory response caused by necrosis of pancreatic alveolar cells. At present, the c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/727A61P1/18
CPCA61K31/727A61P1/18
Inventor 闫昳姝杨晶汤旭娇戴雨桐柯雪张娜
Owner JIANGNAN UNIV
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