Intraoperative Nociceptive Stimulus Response Monitoring System and Method Based on EEG Coupling Relationship

Abstract

The invention discloses a system and a method for monitoring the reactivity of an intraoperative injury stimulus based on an EEG coupling relationship. Obtain intraoperative multi-channel EEG data, and use the patient's response after the occurrence of the noxious stimulus as a label; extract intra-channel and inter-channel MI values ​​from the preprocessed multi-channel EEG data; label the intra-channel and inter-channel MI values The feature construction data set is divided into training set and test set; the training set is used to train the random forest classifier, and the test set is used to verify and optimize the trained random forest classifier. Noxious stimulus monitoring methods based on autonomic nerves are easily affected by drugs and external factors, while noxious stimulus monitoring methods based on EEG nonlinear characteristics, such as entropy index, introduce frontal myoelectric spectrum entropy, which reduces the interpretability of indicators and is susceptible to Muscle relaxant drug interference. The coupling phase-amplitude mode adopted in the present invention is an inherent state under anesthesia, and the sensitivity of the index to electromyographic signals is reduced, which has high specificity.

Description

technical field [0001] The invention relates to the field of intraoperative sedation and analgesia monitoring, in particular to a system and method for monitoring the responsiveness to noxious stimuli during an operation by using an electroencephalogram coupling relationship. Background technique [0002] Intraoperative anesthesia monitoring mainly includes two parts: sedation monitoring and analgesia monitoring. There are relatively effective clinical methods for sedation monitoring, but the means for analgesia monitoring are far from enough. The key to analgesic monitoring is the monitoring of reactivity to noxious stimuli during surgery. At present, there are two main methods for monitoring the reactivity to noxious stimuli: one is based on the activity of autonomic nerves, which monitors the physiological characteristics affected by the autonomic nerves, and this method is easily interfered by factors such as drugs, diseases, and the environment; the other is Based on E...

AI Technical Summary

Problems solved by technology

However, the relationship between frequency spectrum and noxious stimulus reactivity is not clear, the interpretability of nonlinear characteristics is not strong, and the evoked EEG needs to be superimposed multiple times and the anti-interference ability is weak, which restricts the monitoring method based on EEG.

[0003] Research on anesthesia consciousness has proved that the change of EEG coupling mode is one of the main effects of anesthetic drugs on the state of brain consciousness, but for the monitoring of noxious stimulus reactivity, there is currently a lack of monitoring of noxious stimulus reactivity based on EEG coupling relationship Methods

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