Skin disinfection microemulsion gel and preparation method thereof

A technology of microemulsion gel and skin disinfection, which is applied in skin diseases, pharmaceutical formulations, emulsion delivery, etc. It can solve problems such as decreased liver detoxification function, decreased immunity, and damage to liver cell cancer, and achieves good user experience and ease of use. Excellent effect of coating, bactericidal and antibacterial effects

Inactive Publication Date: 2021-07-13
SHANDONG NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, surfactants also reduce the detoxification function of the liver, causing the toxins that should be excreted to accumulate in the body, resulting in a decrease in the body's immunity, which may damage liver cells and induce cancer, etc.

Method used

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Examples

Experimental program
Comparison scheme
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preparation example Construction

[0038] The second aspect of the present invention provides a method for preparing the above-mentioned skin disinfecting microemulsion gel, comprising the following steps:

[0039] (1) Ethanol, methyl salicylate, and eugenol are mixed and stirred to obtain liquid A, left to stand, and set aside;

[0040] (2) Sodium hyaluronate and water are mixed and stirred to obtain liquid B, which is left to stand and set aside;

[0041] (3) Slowly add liquid A to liquid B, stir, and then sonicate to obtain a microemulsion gel product for skin disinfection.

[0042]In one or more embodiments of the present invention, in the step (1), the stirring process is carried out in a blender with a fixed rotation speed of 1000 r / min and a stirring time of 15-30 min.

[0043] In one or more embodiments of the present invention, in the step (2), the stirring process is carried out in a blender with a fixed rotation speed of 500 r / min and a stirring time of 12-24 hours.

[0044] In one or more embodime...

Embodiment 1

[0047] A microemulsion gel for skin disinfection, comprising the following components in mass percentage: 50% ethanol, 0.5% methyl salicylate, 0.006% eugenol, 1.5% sodium hyaluronate, and the balance is water. Sodium hyaluronate has a molecular weight of 1200kDa.

[0048] The method for preparing described microemulsion gel, comprises the following steps:

[0049] Step 1, sequentially put 50% ethanol, 0.5% methyl salicylate, and 0.006% eugenol into the stirrer at a fixed speed of 1000 r / min, and stir for 15 minutes to obtain liquid A, stand still, and set aside;

[0050] Step 2, adding 1.5% by mass of the moisturizing ingredient sodium hyaluronate and 47.99% of water into another stirrer at a fixed speed of 500r / min, stirring for 12 hours to obtain liquid B, standing still, and set aside;

[0051] Step 3: Slowly add liquid A to liquid B, stir while adding, the fixed speed is 500r / min, continue to stir for 1 hour after the addition, and ultrasonicate for 15 minutes to obtain a...

Embodiment 2

[0053] A microemulsion gel for skin disinfection, comprising the following components in mass percentage: 55% ethanol, 1.0% methyl salicylate, 0.01% eugenol, 1.0% sodium hyaluronate, and the balance is water. Sodium hyaluronate has a molecular weight of 800kDa.

[0054] The method for preparing described microemulsion gel, comprises the following steps:

[0055] Step 1, sequentially put 55% ethanol, 1.0% methyl salicylate, and 0.01% eugenol into the stirrer at a fixed speed of 1000 r / min, and stir for 20 minutes to obtain liquid A, stand still, and set aside;

[0056] Step 2, adding 1.0% by mass of the moisturizing ingredient sodium hyaluronate and 42.99% of water into another mixer at a fixed speed of 500r / min, and stirring for 15 hours to obtain liquid B, which was left to stand for later use;

[0057] Step 3: Slowly add liquid A to liquid B, stir while adding, the fixed speed is 500r / min, continue to stir for 1 hour after the addition, and ultrasonicate for 15 minutes to o...

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Abstract

The invention belongs to the technical field of disinfection gel, and particularly relates to skin disinfection microemulsion gel and a preparation method thereof. The skin disinfection microemulsion gel is prepared from the following components in percentage by mass: 50 to 60 percent of ethanol, 0.5 to 3 percent of methyl salicylate, 0.006 to 0.1 percent of eugenol and other skin acceptable carriers. The skin disinfection microemulsion gel has no surfactant, the ethanol is compounded with the methyl salicylate and the eugenol to achieve a synergistic bactericidal and bacteriostatic effect, and the bactericidal and bacteriostatic effect of the skin disinfection microemulsion gel is excellent. Meanwhile, the high-moisturizing component sodium hyaluronate is added, so that the irritation to the skin is reduced, the skin is kept moist, and the skin is moisturized and maintained.

Description

technical field [0001] The invention belongs to the field of disinfection gel technology, and in particular relates to a skin disinfection microemulsion gel without surfactant and a preparation method thereof. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] People are often exposed to a variety of pathogenic microorganisms in daily life, and some pathogenic microorganisms can affect human health and even threaten life safety. Therefore, disinfection gel products have become indispensable daily necessities in people's lives. Most of the disinfection gel products currently on the market use triclosan, ethanol, etc. as active ingredients for sterilization. Triclosan is an i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/618A61K31/085A61K31/045A61K31/728A61P31/04A61P17/00A61P31/02A61P31/10
CPCA61K9/06A61K9/0014A61K31/618A61K31/085A61K31/045A61K31/728A61P31/04A61P17/00A61P31/02A61P31/10
Inventor 柴金岭韩颖李德杰
Owner SHANDONG NORMAL UNIV
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