Implantable electrode device and preparation method thereof
An electrode device and implantable technology, applied in the field of medical testing, can solve problems affecting the quality of life of the target object, high risk of accidents, endogenous inflammatory damage, etc., to achieve improved electric field permeability, easy long-term use, thermal The effect of little damage
Active Publication Date: 2021-07-13
PEKING UNION MEDICAL COLLEGE HOSPITAL CHINESE ACAD OF MEDICAL SCI
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Problems solved by technology
As a foreign body, the implanted electrodes are likely to cause rejection of the body and cause endogenous inflammatory damage;
[0008] Furthermore, the electrodes implanted in the existing implantable devices still have the problem of heat production, and the brain tissue of the target object is sensitive to temperature, high temperature can easily induce epilepsy, affect the quality of life of the target object, and the risk of accidents is relatively high
Method used
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[0033] Various exemplary embodiments, features, and aspects of the present disclosure will be described in detail below with reference to the accompanying drawings. The same reference numbers in the figures indicate functionally identical or similar elements. While various aspects of the embodiments are shown in drawings, the drawings are not necessarily drawn to scale unless specifically indicated.
[0034] The word "exemplary" is used exclusively herein to mean "serving as an example, embodiment, or illustration." Any embodiment described herein as "exemplary" is not necessarily to be construed as superior or better than other embodiments.
[0035] In addition, in order to better illustrate the present disclosure, numerous specific details are given in the following specific implementation manners. It will be understood by those skilled in the art that the present disclosure may be practiced without some of the specific details. In some instances, methods, means, componen...
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Abstract
The invention relates to an implantable electrode device and a preparation method thereof. The device comprises a skull-imitating component and an electrode component, the skull-imitating component comprises a bottom plate and a top plate, the bottom plate is provided with an embedding groove, the top plate is correspondingly provided with a top column, the top column is inserted into the embedding groove so that the top plate can be connected with the bottom plate, and the skull-imitating component is used for being implanted into a skull defect area of an object; and the electrode component comprises at least one electrode, is arranged in the embedded groove, and is used for generating an alternating electric field targeting a target part in the object according to the alternating current signal transmitted by the electric field generation component. The electrode device disclosed by the invention takes the skull-imitating component as a carrier, can be implanted into a skull defect area corresponding to an object, can improve the permeability of an electric field and increase the electric field intensity of an alternating electric field at a target part compared with an in-vitro device used in related technologies, and is good in heat insulation property, small in heat damage, high in safety, flexible, convenient and easy to use for a long time.
Description
technical field [0001] The disclosure relates to the technical field of medical detection, in particular to an implantable electrode device and a preparation method thereof. Background technique [0002] Tumor treating fields (Tumor Treating Fields, TTFields) interfere with the tubulin and spacer proteins of rapidly proliferating tumor cells by applying low-intensity, medium-frequency (for example, 100kHz-300kHz) alternating electric fields, thereby affecting tumor cell mitosis and inhibiting tumor grow. TTFields has been proven to be effective in in vitro studies of various solid tumors including glioblastoma (GBM), and has shown significant survival benefits and good safety in phase III clinical trials. [0003] In related technologies, the alternating electric field is generated, transmitted and controlled by a wearable device located outside the body. The main components of the wearable device include a battery for providing power to the wearable device, an electric fie...
Claims
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IPC IPC(8): A61N1/05A61N1/375A61N1/36
CPCA61N1/0529A61N1/0539A61N1/37514A61N1/37518A61N1/3754A61N1/36002
Inventor 刘芃昊王裕马文斌邢浩温小妍
Owner PEKING UNION MEDICAL COLLEGE HOSPITAL CHINESE ACAD OF MEDICAL SCI