A kind of covalent organic polymer based on porphyrin and its preparation method and application
A covalent organic and polymer technology, applied in the field of medicine, can solve problems such as the limitation of photodynamic therapy efficacy, achieve high-efficiency anti-tumor treatment, simple synthesis steps, and enhance the effect of treatment
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[0028] The preparation method of above-mentioned covalent organic polymer based on porphyrin, comprises the following steps:
[0029] Step 1, prepare TAPP.
[0030]Dissolve 11 g of p-nitroformaldehyde and 12 mL of acetic anhydride into 300 mL of propionic acid solution, slowly drop 5 mL of pyrrole into the above solution, and reflux and stir in an oil bath at 138 °C for 1 hour. After the reaction was completed and the solution was cooled to room temperature, the above solution was filtered and fully washed with methanol, and dried in vacuum at 100° C. to obtain a black solid. Add the solid powder to 80 mL of pyrrole solution, reflux and stir in an oil bath at 117 °C for 1 hour, after the reaction is completed and the solution is cooled to room temperature, add 30 mL of methanol to the above solution, and place the mixture in- Freeze overnight at 4°C. The above-mentioned mixed solution was filtered, fully washed with methanol and acetone successively until the filtrate was cl...
Embodiment 1
[0049] (1) Preparation of TAPP.
[0050] Dissolve 11 g of p-nitroformaldehyde and 12 mL of acetic anhydride into 300 mL of propionic acid solution, slowly drop 5 mL of pyrrole into the above solution, and reflux and stir in an oil bath at 138 °C for 1 hour. After the reaction was completed and the solution was cooled to room temperature, the above solution was filtered and fully washed with methanol, and dried in vacuum at 100° C. to obtain a black solid. Add the solid powder to 80 mL of pyrrole solution, reflux and stir in an oil bath at 117 °C for 1 hour, after the reaction is completed and the solution is cooled to room temperature, add 30 mL of methanol to the above solution, and place the slurry mixture in- Freeze overnight at 4°C. The above-mentioned mixed solution was filtered, fully washed with methanol and acetone successively until the filtrate was clear, and after vacuum drying at 100 ° C, a dark red solid [H 2 T(NO 2 )PP]. 1g H 2 T(NO 2 )PP and 4.5g tin chlor...
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