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External agent for hair growth or hair loss prevention

A technology of external preparations and lactic acid bacteria, applied in the field of external preparations, can solve the problem of not assuming the use of external preparations

Active Publication Date: 2021-07-23
NICHINICHI SEIYAKU
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, Patent Documents 1 to 7 basically disclose oral administration of lactic acid bacteria, and do not assume their use as an external preparation

Method used

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  • External agent for hair growth or hair loss prevention
  • External agent for hair growth or hair loss prevention
  • External agent for hair growth or hair loss prevention

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0065] The following examples are given to illustrate the invention in more detail. However, the present invention is not limited to these Examples.

[0066] 1. Cell sample preparation: FK-23

[0067] Enterococcus faecalis NF-1011 strain was cultured in a liquid medium (glucose: 2%, yeast extract: 2%, peptone: 2%, dipotassium hydrogenphosphate: 4%) at 37° C. for 18 hours. Using microfiltration membranes, harvest and wash to collect viable cells. Live cells were heat-treated at 110 °C for 10 min and then dried by spray drying. The resulting dried dead cells were used as cell samples (FK-23) in the following experiments.

[0068] 2. Cell Sample Preparation: LFK

[0069] Enterococcus faecalis NF-1011 strain was inoculated in 10 ml Rogosa liquid medium, and aerobic static culture (preliminary culture) was carried out at 37°C for 15 hours to obtain a cell concentration of approximately 10 9 cells / ml of cell solution (seed). Cells were inoculated in 10L of Rogosa liquid medium...

experiment example 1

[0071] In a 39-year-old male individual, hair styling products were applied once a day by suspending 1% powder (in which FK-23 and LFK were mixed in a 1:1 ratio) in a solution containing ethanol and water as the main components. Obtained, primarily for use on visible bare skin on the scalp and areas of individual concern. The use time is not specified. However, individuals primarily use the product before going to bed and when shampooing after the hair is dry.

[0072] figure 1 A photograph representing the top of the head of a male individual after initiation of use is shown. Subject started using the product on June 5, 2018. From June 19 to July 3, 2018, an increase in hair was observed visually.

experiment example 2

[0074] The same styling product as in Experimental Example 1 was used once a day on five male and female subjects aged 40-70, mainly on the visible bare skin on the scalp and areas of concern to the subjects. The use time is not specified. However, individuals primarily use the product before going to bed and when shampooing after the hair is dry.

[0075] figure 2 with image 3 Photographs representing the top of each individual's head after initiation of use are shown. It was confirmed that in individuals with rapid results, bare skin became less noticeable after the fourth week of use, whereas in individuals with slow results, bare skin became less noticeable at eighth week.

[0076] Form PCT / RO / 134

[0077]

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PUM

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Abstract

Disclosed is an external agent for hair growth or hair loss prevention, said external agent comprising at least one member selected from the group consisting of cells of a lactic acid bacterium belonging to the genus Enterococcus and a cell component thereof.

Description

technical field [0001] The present invention relates to an external preparation for hair growth and prevention of hair loss. Background technique [0002] Lactic acid bacteria belonging to the genus Enterococcus are known to have various effects on living organisms. [0003] For example, Enterococcus faecalis NF-1011 strain has been reported to have the following effects: suppression of blood pressure increase and prevention of cardiac hypertrophy (Patent Document 1), immunostimulatory effect (Patent Document 2), enhancement of interferon production (Patent Document 3 ), preventing infection (Patent Document 4), enhancing anticancer properties (Patent Document 5), reducing the toxicity of anticancer drugs (Patent Document 6) and activating biological antioxidant capacity (Patent Document 7). [0004] However, Patent Documents 1 to 7 basically disclose oral administration of lactic acid bacteria, and do not assume their use as external preparations. [0005] citation list ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/744A61K8/99A61P17/14A61Q7/00
CPCA61K35/744A61Q7/00A61K8/99A61P17/14A61Q5/06
Inventor 嶋田贵志北村守
Owner NICHINICHI SEIYAKU
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