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Composition with the function of enhancing macrophage phagocytic activity and its application and immune medicine
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A technology of macrophages and compositions, which is applied in the field of medicine, can solve problems such as limitations, and achieve the effect of enhancing phagocytic activity
Active Publication Date: 2022-07-15
国珍健康科技(北京)有限公司
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However, the current stimulating substances are relatively limited, and the effect of enhancing the phagocytic ability of macrophages is given priority. It is necessary to find other substances that can improve the phagocytic activity of macrophages
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preparation example Construction
[0051] In a preferred embodiment, the preparation method of the pine flower water extract comprises the steps:
[0052] The preparation method of described pine flower water extract comprises the steps:
[0053] Mixing pine pollen with water, and ultrasonically preparing the pine flower water extract under heating conditions;
[0054] Preferably, the mass ratio of the pine pollen mixed with water is 1:(8-12), such as, but not limited to, 1:8, 1:9, 1:10, 1:11 or 1:12, preferably is 1:10;
[0055] Preferably, the heating temperature is 25-45°C, such as, but not limited to, 25°C, 30°C, 35°C, 40°C or 45°C, preferably 37°C;
[0056] Preferably, the ultrasonic time is 10 to 30 minutes, such as, but not limited to, 10 minutes, 15 minutes, 20 minutes, 25 minutes or 30 minutes, preferably 20 minutes.
[0057] In the present invention, by further optimizing and adjusting the preparation method of pine flower water extract, the extraction of effective substances in pine pollen can be re...
[0079] (1) Fucoidan: Take 200mg of Fucoidan in 2ml of hot water, ultrasonicate for 10min, fully dissolve, pass through a 0.22 μm filter membrane, and prepare a 100mg / ml Fucoidanstock solution, which is placed in a 5°C refrigerator for later use.
[0080] (2) Elderberry: Weida International Co., Ltd., containing 10% anthocyanins, prepared 40mg / ml elderberry stock, dissolved 200mg extract in 5ml water, sterilized through 0.22μm filter, -20℃ Reserve for spare.
[0081] (3) Pterostilbene: Take 200 mg of Pterostilbene in 2 ml of 50% alcohol, fully dissolve by pipetting, pass through a 0.22 μm filter membrane, and prepare a 100 mg / ml Pterostilbenestock solution, which is placed in a 5°C refrigerator for later use.
[0082] (4) Aqueous extract of pine flower: take 500mg pine pollen in 5ml of water, water bath at 37°C, ultrasonic for 20min, pass through a 0.22 μm filter membrane to prepare a 100mg / ml pine flower water extract stock solution, whi...
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Abstract
The invention provides a composition with the function of enhancing the phagocytic activity of macrophages and its application and immune medicine, and relates to the technical field of medicine. The composition with the function of enhancing the phagocytic activity of macrophages provided by the present invention includes fucoidan and elderberry. The inventor's experimental research found that both fucoidan and elderberry have immunoregulatory functions, which can enhance the phagocytic activity and phagocytic effect of macrophages. Inhibiting lipopolysaccharide-induced macrophage secretion of nitric oxide, the co-use of fucoidan and elderberry has a significantly better effect on enhancing the phagocytic activity of macrophages than a single component. There is a synergistic effect between fucoidan and elderberry. It is safe and reliable, and can be used to prepare a drug for enhancing the phagocytic activity of macrophages.
Description
technical field [0001] The invention relates to the technical field of medicine, in particular to a composition with the function of enhancing the phagocytic activity of macrophages and its application and immune medicine. Background technique [0002] Macrophages are white blood cells located in tissues, derived from monocytes, and play an important role in body development, immunity, inflammatory response and the occurrence of various diseases by phagocytosing autologous damaged cells or foreign pathogens. That said, they are implicated in nearly every human disease, and they are also primary therapeutic targets because their function can be enhanced or inhibited to alter disease outcomes. Therefore, improving the phagocytic activity of macrophages contributes to the improvement of the body's immune level and the treatment of various diseases. [0003] Existing studies have shown that macrophages in biological organisms can change their phenotype and immune function with ...
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