Automatic classification method and system for pathological diagrams of cell and region levels

A pathology and cell technology, applied in the field of image analysis, can solve problems such as difficulty in determining more detailed information, inability to classify patients for treatment, lack of cell-level analysis and classification, etc.

Active Publication Date: 2021-07-30
HUAZHONG UNIV OF SCI & TECH
View PDF5 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The macroscopic situation of cancer development can be identified through clinical index detection, X-ray and other methods, but it is difficult to determine more detailed information, so it is impossible to refine and individualize the classification and treatment of patients
The current pathological image analysis and classification methods are mainly concentrated at the block level, lacking analysis and classification at the cell level and physiological regions

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Automatic classification method and system for pathological diagrams of cell and region levels
  • Automatic classification method and system for pathological diagrams of cell and region levels
  • Automatic classification method and system for pathological diagrams of cell and region levels

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0078] The method and system of the present invention will be described in detail below by taking the stained tissue section of a cervical cancer patient as an example. We collected 664 pieces of cancer and paracancerous tissue slices of cervical cancer patients from Tongji Hospital for backup data sets and final implementation cases. For example, the pathological map can be cut into a large image of 5120*5120. Specific steps are as follows:

[0079](1) First select some of the pictures, cut and screen 1689 small pictures with a size of 128*128 pixels as the training set for cell cutting and positioning, and manually use Adobe Photoshop CC2018 to draw the corresponding cell mask picture as a label, mask It is a single-channel grayscale image, marking the whole cell with white, and covering other parts with black, so as to obtain the pixel label corresponding to the cell image.

[0080] In this step (1), the mask is hand-painted, the part with a gray value less than 180 is def...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention belongs to the field of image analysis, and discloses an automatic classification method and system for pathological diagrams of cell and regional hierarchies, and the method comprises the following steps: (1) cutting an initial pathological diagram into small diagrams, and drawing a cell mask diagram; (2) carrying out image segmentation on the small image to obtain cell coordinates; (3) cutting the initial pathological map into single cell small maps, and judging cell types; (4) cutting the initial pathological diagram into small diagrams, and judging whether the small diagrams belong to a cancerous region and a para-cancerous region or not; (5) cutting the initial pathological diagram into small diagrams, and respectively judging whether the small diagrams belong to a tumor tissue parenchyma region, a mesenchymal region, a protein keratinization region and a vessel region or not; (6) integrating the scores, and determining the cell type and the belonging region thereof. According to the method, the overall process processing of the method is improved, so that the defect that the analysis of the pathological diagram stays in block type analysis in the prior art can be overcome, the information of the pathological diagram is deeply mined, and therefore, the automatic classification of the pathological diagram is realized.

Description

technical field [0001] The invention belongs to the field of image analysis, and more specifically relates to a method and system for automatically classifying pathological maps at cell and region levels. Background technique [0002] Pathological maps often contain a lot of information. The macroscopic situation of cancer development can be identified through clinical index detection, X-ray and other methods, but it is difficult to determine more detailed information, so it is impossible to refine and individualize the classification and treatment of patients. The current pathological image analysis and classification methods are mainly concentrated at the block level, lacking analysis and classification at the cell level and physiological regions. Contents of the invention [0003] In view of the above defects or improvement needs of the prior art, the purpose of the present invention is to provide a method and system for automatic classification of pathological maps at...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): G06T7/11G06T7/00G06N3/08G06N3/04
CPCG06T7/11G06T7/0012G06N3/08G06T2207/30204G06T2207/30096G06N3/045
Inventor 薛宇苟宇杰宁万山彭迪付珊珊刘丹
Owner HUAZHONG UNIV OF SCI & TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products