Reflection-type glucose sensor based on gold nanocomposite optical fiber and measuring system

Abstract

The invention discloses a reflection-type glucose sensor based on a gold nanocomposite optical fiber and a measuring system. The optical fiber adopts a glucose sensitive hydrogel material doped with gold nanoparticles as a base material, and meanwhile, the end surface of the optical fiber is chemically coated by utilizing silver mirror reaction, so that the action length of signal light and the sensing optical fiber is increased, and the detection sensitivity of the sensing optical fiber is improved. Compared with a transmission-type optical fiber sensor, the reflection-type sensing structure can perform glucose monitoring through a single insertion point, and has the advantages of compact structure, convenience in installation, good reliability and the like. Glucose molecules are specifically combined with glucose sensitive functional groups modified in the sensing optical fiber, so that the volume of the optical fiber is changed, and the LSPR (Local Surface Plasmon Resonance) absorption intensity of the gold nanoparticles is changed. By detecting the change of the LSPR peak intensity of the reflected light signal, the real-time and quantitative detection of the glucose can be realized.

Description

[0001] (1) Technical field [0002] The invention relates to a reflective glucose sensor and measurement system based on gold nanocomposite optical fiber, which is used for continuous long-term blood sugar monitoring and belongs to the technical field of optical detection and organic material application. [0003] (2) Background technology [0004] Glucose is one of the important substances involved in the life activities of the human body. The blood sugar range of a healthy human body is 4-8mM, while the blood sugar concentration of diabetic patients is much higher than this concentration. Excessively high blood sugar concentration breaks the coordination of various systems of the human body and seriously affects the human body. health. In addition, excessive fluctuations in blood sugar may induce many serious complications, including renal failure, neuropathy, and cardiovascular disease. In 2019, the number of diabetic patients in the world was as high as 463 million, and it...

AI Technical Summary

Problems solved by technology

Traditional blood glucose monitoring uses a single-point glucose sensor. For patients who require multiple insulin injections or use insulin pump therapy, 6-8 finger punctures are required to measure blood glucose concentration every day, which not only brings great physiological pressure to patients. Pain and many potential safety hazards, and the collected blood sugar data is discrete data that cannot accurately reflect the real blood sugar change trend, which directly interferes with the doctor's judgment on the condition, and even leads to misdiagnosis

Continuous continuous blood glucose monitoring is of great significance for effectively managing blood glucose levels in diabetic patients and improving the quality of life of patients, but there is no long-term implantable glucose sensor available for clinical use

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