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High-sensitivity rare earth doped time-resolved fluorescent nanoparticle, and preparation method and application thereof

A time-resolved fluorescence and rare earth doping technology, which is applied in the fields of chemistry and materials, can solve the problems of low fluorescence quantum yield, weak photostability, and low sensitivity of detection results, and achieve high-sensitivity detection, reduced interference, and excellent light The effect of physical properties

Active Publication Date: 2021-08-13
HUAZHONG UNIV OF SCI & TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Benefits of technology

This patented technique uses specific chemicals called pigments (TAT), such as tetraazacyclodium salt(TPA). These chemistries enhance the efficiency at excitation wavelength conversion when quantum dots absorb UV lights. They also improve the ability to detect small amounts of materials without being affected by their surrounding environments. Additionally, they allow for precise control over how much laser radiation interacts with these particles during imaging processes. Overall, this new approach improves both luminous characteristics and sensibility of rare earth dopants used in various applications like bioimaging, medical diagnoses, and environmental monitoring.

Problems solved by technology

The technical problem addressed in this patented text relating to improving the performance of rare metal-based fluorescein probe for detecting biological samples like blood or urine without losing light due to photobleaching caused by exposure during storage.

Method used

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  • High-sensitivity rare earth doped time-resolved fluorescent nanoparticle, and preparation method and application thereof
  • High-sensitivity rare earth doped time-resolved fluorescent nanoparticle, and preparation method and application thereof
  • High-sensitivity rare earth doped time-resolved fluorescent nanoparticle, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Example 1 TTA / Phen sensitized rare earth doped fluorescent nanoparticles

[0039] (1) Weigh 29.71mg (0.8mmol) LaCl 3 ·7H 2 O and 7.33 mg (0.2 mmol) EuCl 3 ·6H 2 O, dissolved in 25mL ultrapure water, stirred and mixed;

[0040] (2) Weigh 11.11mg (3mmol) NH 4 F, dissolved in 6mL ultrapure water, added dropwise to the rare earth hydrochloride solution under stirring, controlled the speed of the peristaltic pump, and adjusted the dropping rate to 1mL / min, the color of the reaction solution changed from the original colorless to Transparency gradually becomes slightly bluish opalescent;

[0041] (3) Weigh 22.22mg (0.1mmol) of 2-thienoyltrifluoroacetone (TTA), 19.82mg (0.1mmol) of 1,10-phenanthroline (Phen), dissolve them in 1mL of ethanol solution, and slowly Add dropwise to NH 4 F, in the mixed solution of rare earth hydrochloride;

[0042] (4) Stir and react overnight at room temperature, take out the reaction solution, centrifuge at 12000rpm for 10min, repeat wash...

Embodiment 2

[0044] Example 2 TTA / Phen sensitized rare earth doped fluorescent nanoparticles

[0045] (1) Weigh 22.28mg (0.6mmol) LaCl 3 ·7H 2 O and 14.66 mg (0.4 mmol) EuCl 3 ·6H 2 O, dissolved in 25mL ultrapure water, stirred and mixed;

[0046] (2) Weigh 11.11mg (3mmol) NH 4 F, dissolved in 6mL ultrapure water, added dropwise to the rare earth hydrochloride solution under stirring, controlled the speed of the peristaltic pump, and adjusted the dropping rate to 1mL / min, the color of the reaction solution changed from the original colorless to Transparency gradually becomes slightly bluish opalescent;

[0047] (3) Weigh 22.22mg (0.1mmol) of 2-thienoyltrifluoroacetone (TTA), 19.82mg (0.1mmol) of 1,10-phenanthroline (Phen), dissolve them in 1mL of ethanol solution, and slowly Add dropwise to NH 4 F, in the mixed solution of rare earth hydrochloride;

[0048] (4) Stir and react overnight at room temperature, take out the reaction solution, centrifuge at 12000rpm for 10min, repeat was...

Embodiment 3

[0050] Example 3 TTA / Phen sensitized rare earth doped fluorescent nanoparticles

[0051] (1) Weigh 14.85mg (0.4mmol) LaCl 3 ·7H 2 O and 21.98 mg (0.6 mmol) EuCl 3 ·6H 2 O, dissolved in 25mL ultrapure water, stirred and mixed;

[0052] (2) Weigh 11.11mg (3mmol) NH 4 F, dissolved in 6mL ultrapure water, added dropwise to the rare earth hydrochloride solution under stirring, controlled the speed of the peristaltic pump, and adjusted the dropping rate to 1mL / min, the color of the reaction solution changed from the original colorless to Transparency gradually becomes slightly bluish opalescent;

[0053] (3) Weigh 22.22mg (0.1mmol) of 2-thienoyltrifluoroacetone (TTA), 19.82mg (0.1mmol) of 1,10-phenanthroline (Phen), dissolve them in 1mL of ethanol solution, and slowly Add dropwise to NH 4 F, in the mixed solution of rare earth hydrochloride;

[0054] (4) Stir and react overnight at room temperature, take out the reaction solution, centrifuge at 12000rpm for 10min, repeat was...

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Abstract

The invention discloses a high-sensitivity rare earth doped time-resolved fluorescent nanoparticle, and a preparation method and application thereof, and belongs to the technical field of chemistry and materials. According to the fluorescent nanoparticle, LaF3 is used as a hexagonal phase matrix material, Eu<3+> is used as a luminescence center to be doped into a hexagonal phase LaF3 matrix, and a sensitizer 2-thenoyltrifluoroacetone and 1, 10-phenanthroline are coordinated with Eu<3+>. The method comprises the following steps: dropwise adding an NH4F aqueous solution into a mixed aqueous solution of LaCl3 and EuCl3, and then adding an alcoholic solution of 2-thiophenoyl trifluoroacetone and an alcoholic solution of 1, 10-phenanthroline. According to the invention, TTA is adopted as the sensitizer, Phen is adopted as a non-water auxiliary ligand, resonance energy transfer between TTA and Eu<3+> ions is utilized, and Phen replaces a fluorescence quenching group -OH to generate strong coordination with the Eu<3+> ions, so that the fluorescence of the nanoparticles is effectively enhanced.

Description

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Claims

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Application Information

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Owner HUAZHONG UNIV OF SCI & TECH
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