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Application of Sonidegib in preparation of medicine for treating ankylosing spondylitis

A technology of sonidegib, 1.sonidegib, applied in the field of application of sonidegib in the preparation of drugs for the treatment of ankylosing spondylitis

Inactive Publication Date: 2021-08-27
NANJING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

There is no report about the therapeutic effect of autoimmune diseases, especially ankylosing spondylitis

Method used

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  • Application of Sonidegib in preparation of medicine for treating ankylosing spondylitis
  • Application of Sonidegib in preparation of medicine for treating ankylosing spondylitis
  • Application of Sonidegib in preparation of medicine for treating ankylosing spondylitis

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Embodiment 1

[0021] 1. Pharmacological experiment of Sonidegib: conditional knockout (CD4-Cre; SHP2 f / f ) mouse spontaneous ankylosing spondylitis model (as recorded in CN106177999B)

[0022] SHP2 on C57BL / 6 background f / f and CD4-Cre; SHP2 f / f Female mice were kept in an SPF grade animal room at 21±2°C, with free access to water and food, and alternated day and night for 12 hours. At the age of 7 months, they were randomly divided into two groups. The control group was given solvent control, and the treatment group was given 100 mg / kg sonidegib by intragastric administration. The mice were administered for 4 months, and the symptoms of bone lesions in the mice were monitored in real time. At present, the treatment drugs for ankylosing spondylitis still focus on anti-inflammatory treatment, including non-steroidal anti-inflammatory drugs, TNF-α antibody and IL-17 blocking factor. None of the existing drugs can significantly improve the symptoms of ectopic bone formation and osteoarthri...

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Abstract

The invention belongs to the technical field of pharmacy. According to the application of the Sonidegib in preparation of the medicine for treating the ankylosing spondylitis, aiming at an SHP2 conditional knockout (CD4-Cre; SHP2f / f) mouse spontaneous ankylosing spondylitis-like bone lesion model, the sonidegib can effectively improve symptoms such as ectopic osteogenesis, articular bone fusion and osteoporosis of a mouse.

Description

technical field [0001] The invention relates to a new application of Sonidegib, an inhibitor of Smoothened (SMO), in particular to the application of sonidegib in the preparation of medicines for treating ankylosing spondylitis. Background technique [0002] The Smo inhibitor Sonidegib inhibits cell survival and proliferation by inhibiting the hedgehog signaling pathway, and is mainly used clinically for the treatment of tumors. Sonidegib induces cell arrest and apoptosis in glioblastoma, prostate cancer, and renal cell carcinoma cells. In July 2015, the FDA approved sonidegib for the treatment of locally advanced basal cell carcinoma that has recurred after surgery or radiation therapy. There is no report about the therapeutic effect of autoimmune diseases, especially ankylosing spondylitis. This study mainly found that sonidegib has an effect on conditional knockout (CD4-Cre; SHP2 f / f ) significantly improved the spontaneous ankylosing spondylitis-like bone lesions in m...

Claims

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Application Information

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IPC IPC(8): A61K31/5377A61P19/08A61P29/00A61P19/10A61P19/02
CPCA61K31/5377A61P19/08A61P29/00A61P19/10A61P19/02
Inventor 孙洋徐强邵粉丽
Owner NANJING UNIV
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