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Method and apparatus for ion mobility separations utilizing alternating current waveforms

A kind of equipment and ion technology, which is applied in the field of performing ion manipulation and ion manipulation, can solve the problem of the ability to separate ions (separation capacity limitation, etc.)

Pending Publication Date: 2021-09-03
BATTELLE MEMORIAL INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is worth noting that conventional IMS devices are limited in their ability to separate ions (separation capacity) due to practical limitations in the size and complexity of the electrode structures that generate the electric field that separates the ions

Method used

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  • Method and apparatus for ion mobility separations utilizing alternating current waveforms
  • Method and apparatus for ion mobility separations utilizing alternating current waveforms
  • Method and apparatus for ion mobility separations utilizing alternating current waveforms

Examples

Experimental program
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Effect test

example 1

[0154] Example 1 - Simulation of a planar surface

[0155] (i) AC-SLIMS simulation parameters

[0156] figure 1 The schematic modules shown are used for simulations. The AC electrode 125 is a segmented electrode adjacent to the long RF electrode strips 110,120. The guard electrode 130 is located on the outside of the AC electrode 125 and the RF electrodes 110 , 120 . The modules were fabricated using PCBs and consisted of a pair of parallel PCBs (30.5 cm long x 7.6 cm wide) separated by a gap of 4.75 mm. The module uses an array of 5 AC electrodes 125 separated from adjacent arrays of RF electrodes 110 and 120 by 0.13 mm. The dimensions of the AC electrode 125 are 1.98 mm long and 0.43 mm wide. The guard electrodes 130 are each 0.508 mm wide. The dimensions of the RF electrodes 110 and 120 are both 0.43 mm wide.

[0157] The module was operated at a pressure of 4 Torr using nitrogen as a buffer gas. Singly charged ions with mass-to-charge ratios (m / z) of 622 and 922 we...

example 2

[0177] Example 2 - Simulation of curved surfaces

[0178] (i) AC-SLIMS simulation parameters

[0179] image 3 The schematic modules shown are used for simulations. The curved AC electrode 325 is a segmented electrode adjacent to the long curved RF electrode strips 310 , 320 . The curved guard electrode 330 is located outside the curved electrodes 310 , 320 , 325 .

[0180] The module was manufactured using PCB and consisted of a single PCB (15cm long x 0.5cm wide). The module uses two sets of AC electrodes 325 separated from adjacent RF electrodes 310 and 320 by 0.3mm. The dimensions of the AC electrode 125 are 2mm long and 0.4mm wide. The guard electrodes 130 are each 1 mm wide. The dimensions of the RF electrodes 110 and 120 are each 1 mm wide. The radius of curvature of the electrodes is 3.6 mm.

[0181] The module was operated at a pressure of 4 Torr using nitrogen as a buffer gas. Singly charged ions with mass-to-charge ratios (m / z) of 622 and 922 were used for ...

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Abstract

The invention relates to a method and apparatus for ion manipulation. The device comprises: a first surface for receiving ions, the first surface comprising: a first plurality of electrodes extending in a first direction, where the first electrode receives a first voltage signal and the second electrode receives a second voltage signal; the first electrode is spaced apart from the second electrode along a second direction transverse to the first direction; and a second plurality of electrodes between the first and second electrodes and spaced apart in the first direction, the second plurality of electrodes configured to receive a third voltage signal, AC waveforms applied to adjacent electrodes within the second plurality of electrodes being phase shifted by 1 DEG to 359 DEG to generate a first traveling wave in the first direction, and directing the received ions in a first direction.

Description

[0001] This application is a divisional application of a Chinese invention patent application with an application date of August 15, 2016, an application number of 201680069722.X, and an invention title of "Method and device for ion mobility separation using AC waveforms". technical field [0002] Embodiments of the present disclosure relate to ion mobility separation and related ion manipulation. More specifically, the disclosed embodiments relate to performing ion manipulation including movement in a moving ion trapping region using a continuous alternating current (AC) voltage waveform or multiple continuous AC voltage waveforms applied to one or more segmented electrodes and ion mobility separation. Background technique [0003] Ion mobility spectroscopy (IMS) is a technique used to separate and identify ions. IMS can be used to separate structural isomers and resolve conformational features of macromolecules. IMS can also be used to enhance mass spectrometry (MS) in a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): H01J49/06G01N27/622H01J49/26
CPCG01N27/622H01J49/26H01J49/062G01N27/624H01J49/0027
Inventor V·必斯·加利梅拉A·M·哈米德Y·M·易卜拉欣R·D·史密斯
Owner BATTELLE MEMORIAL INST
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