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Application of anhydroicaritin in preparation of medicine for preventing and treating diseases related to platelet dysfunction

A technology for icariin and abnormal function is applied in the field of icariin in the field of preparing medicines for preventing and treating diseases related to abnormal platelet function.

Pending Publication Date: 2021-09-10
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there is no literature report on the use of icariin in the treatment of diseases related to platelet dysfunction

Method used

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  • Application of anhydroicaritin in preparation of medicine for preventing and treating diseases related to platelet dysfunction
  • Application of anhydroicaritin in preparation of medicine for preventing and treating diseases related to platelet dysfunction
  • Application of anhydroicaritin in preparation of medicine for preventing and treating diseases related to platelet dysfunction

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Formulation Example 1 Icariin Injection

[0025]

[0026] Preparation process: add icariin to the PEG-400 in the prescribed amount, stir to dissolve, add 0.9% sodium chloride solution to 10L, stir evenly, add 0.5% activated carbon for injection, stir, and decarbonize to get the product.

Embodiment 2

[0027] Formulation Example 2 Icariin Injection

[0028]

[0029]

[0030] Preparation process: mix the prescribed amount of ethanol and Tween-80 evenly, add icariin, stir to dissolve, add water for injection to 10L, stir evenly, add 0.5% activated carbon for injection, stir, and decarbonize, and the product is obtained.

Embodiment 3

[0031] Formulation Example 3 Icariin Injection

[0032] Icariin 1g

[0033] Ethanol 3.3L

[0034] Add water for injection to 10L

[0035] Preparation process: adding icariin in prescription amount of ethanol, stirring and dissolving, adding water for injection to 10L, stirring evenly, adding 0.5% activated carbon for injection, stirring, and decarbonizing, and the product is obtained.

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PUM

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Abstract

The invention belongs to the field of medicines, and relates to medical application of anhydroicaritin, in particular to application of anhydroicaritin in preparation of medicines for preventing and treating diseases related to platelet dysfunction. In order to find a specific medicine with a treatment effect on platelet dysfunction, the invention researches the influence of anhydroicaritin on functions of platelet, and results show that anhydroicaritin can promote activation and aggregation functions of platelet, not only has a remarkable treatment effect on diseases caused by hereditary platelet dysfunction, but also has an extremely profound clinical significance in preventing progress of primary diseases causing platelet dysfunction.

Description

technical field [0001] The invention belongs to the field of medicine and relates to the medicinal use of icariin, in particular to the use of icariin in the preparation of a medicine for preventing and treating diseases related to abnormal platelet function. Background technique [0002] Platelet dysfunction (Qualitative plateletdefects) is a group of bleeding disorders caused by defects in platelet adhesion, aggregation, release, procoagulant function and arachidonic acid metabolism. Divided into congenital and acquired two types, children are mostly congenital hereditary, the common feature is that the number of platelets is not significantly reduced, and the platelet function is abnormal: such as prolonged bleeding time, reduced prothrombin consumption, and insufficient thromboplastin generation. The beam arm test was positive, but the coagulation time, prothrombin time, thrombin time, and partial thromboplastin time were normal. Among them, congenital platelet defects ...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P7/02A61P7/00A61P13/12A61P3/10A61P35/00A61P9/10A61P1/16A61P35/02A61P31/00
CPCA61K31/352A61P7/02A61P7/00A61P13/12A61P3/10A61P35/00A61P9/10A61P1/16A61P35/02A61P31/00
Inventor 张贵民潘思娜崔丽娟
Owner LUNAN PHARMA GROUP CORPORATION
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