Method for preparing nicotinamide mononucleotide eutectic

A single nucleotide and nicotinamide technology, which is applied in the preparation of sugar derivatives, chemical instruments and methods, sugar derivatives, etc., can solve the problems of poor fluidity, large differences in the packaging/weight of NMN drugs or health care products, and poor quality. First-class problems, achieve the effects of improving fluidity, solving large differences in loading/weight, and simple operation

Active Publication Date: 2021-09-17
BONTAC BIO ENG SHENZHEN +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] In view of the deficiencies mentioned in the above-mentioned background technology, the object of the present invention is to develop a method for preparing nicotinamide mononucleotide that can obtain nicotinamide mononucleotide crystals with be

Method used

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  • Method for preparing nicotinamide mononucleotide eutectic
  • Method for preparing nicotinamide mononucleotide eutectic
  • Method for preparing nicotinamide mononucleotide eutectic

Examples

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Effect test

Embodiment 1

[0038] Preparation of Nicotinamide Mononucleotide-Isonicotine Co-Crystal by Adopting the Method for Preparing Nicotinamide Mononucleotide Co-Crystal Provided by the Invention

[0039] Dissolve 67g of β-nicotinamide mononucleotide and 24g of isonicotine in 2L of water, then slowly add 2L of tetrahydrofuran dropwise to it, and stir while adding, keep the temperature of the solution at 45°C during the dropwise addition, after the dropwise addition is completed, The temperature of the solution was lowered to 6° C., stood still, and waited for the crystals to precipitate out. After the crystallization was completed, the solution was filtered to obtain the nicotinamide mononucleotide-isonicotine co-crystal.

Embodiment 2

[0041] Preparation of Nicotinamide Mononucleotide-Isonicotine Co-Crystal by Adopting the Method for Preparing Nicotinamide Mononucleotide Co-Crystal Provided by the Invention

[0042] Dissolve 67g of β-nicotinamide mononucleotide and 24g of isonicotine in 2L of water, then slowly add 2L of acetonitrile dropwise to it, stirring while adding, keep the temperature of the solution at 55°C during the dropwise addition, after the dropwise addition is completed, Lower the temperature of the solution to 4°C, let it stand still, wait for the crystals to precipitate, and filter the solution after the crystallization is completed, and obtain the nicotinamide mononucleotide-isonicotine co-crystal.

Embodiment 3

[0044] Preparation of Nicotinamide Mononucleotide-Isonicotine Co-Crystal by Adopting the Method for Preparing Nicotinamide Mononucleotide Co-Crystal Provided by the Invention

[0045] Dissolve 67g of β-nicotinamide mononucleotide and 24g of isonicotine in 2L of water, then slowly add 2L of acetone dropwise, stirring while adding, keep the temperature of the solution at 30°C during the dropwise addition, after the dropwise addition is completed, The temperature of the solution was lowered to 8° C., stood still, and waited for the crystals to precipitate. After the crystallization was completed, the solution was filtered to obtain the nicotinamide mononucleotide-isonicotinic co-crystal.

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Abstract

The invention provides a method for preparing nicotinamide mononucleotide eutectic, and aims to solve the technical problems that the existing nicotinamide mononucleotide crystal has poor fluidity, so that the NMN drug or health product has large loading/weight difference and different quality. The method uses nicotinamide mononucleotide as an active ingredient and isonicotine as an eutectic forming substance, and adopts a solution synthesis method to mix the nicotinamide mononucleotide and the isonicotine for crystallization. The method has the advantages of simple operation and wide application range.

Description

technical field [0001] The invention relates to the technical field of compound crystal preparation, in particular to a preparation method of nicotinamide mononucleotide co-crystal. Background technique [0002] Nicotinamide mononucleotide (NMN) is a biochemical substance inherent in biological cells, which can be adenylated by nicotinamide nucleotide adenylyltransferase in cells to transform into biological cells. An important substance for survival—nicotinamide adenine dinucleotide (abbreviated as NAD, also known as coenzyme I, exists in all cells, participates in thousands of biocatalytic reactions, and plays an important role in the energy generation of biological cells). NMN is the immediate precursor of NAD, which is an important intermediate in the NAD salvage synthesis pathway in biological cells, and its level in biological cells directly affects the concentration of NAD. [0003] Studies have found that supplementing NMN in vitro is the most ideal way to increase ...

Claims

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Application Information

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IPC IPC(8): C07H19/048C07H1/00C07D213/81
CPCC07H19/048C07H1/00C07D213/81C07D213/82C07B2200/13
Inventor 张章陈明
Owner BONTAC BIO ENG SHENZHEN
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