Animal bone suture distraction device and construction method of animal model for cranial suture distraction

Abstract

The invention relates to an animal bone suture distraction device and a construction method of an animal model of cranial suture distraction. The animal bone suture distraction device comprises fixing seats, a rod piece and a spring; two fixing seats are provided; the fixing seats are provided with through holes for the rod piece to penetrate through; and the rod piece can be sleeved with the spring. According to the method, the two fixing seats are bonded to parietal bones on the two sides, the fixing seats penetrate through the skin to be arranged outside the skin, after the skin of a mouse is healed, the spiral spring is arranged between the fixing seats on the two sides, the rod piece penetrates through the spiral spring and the two fixing seats, then limiting parts are additionally arranged on the two sides of the rod piece, and the spiral spring carries out distraction on the cranial suture by applying the tensile stress to the fixing seats on the two sides. The bone suture distraction device disclosed by the invention is stable in effect, high in repeatability and suitable for various types of transgenic mice different in age and size; in an experiment, by changing the force of the spring, the change of the distraction stress in mechanical magnitude can be implemented; and by detaching the spring device, the force removal can be implemented at any time for researching the relapse related research after stress stimulation.

Description

technical field [0001] The invention relates to the technical field of medical experiment devices, in particular to an animal bone suture stretching device and a method for constructing an animal model of cranial suture stretching. Background technique [0002] The craniomaxillary suture is an important growth zone for the growth and development of craniomaxillofacial bones. Abnormal growth of sutures will lead to common craniofacial developmental deformities such as craniosynostosis and underdeveloped maxilla. Clinically, functional orthopedic treatments including cranial distraction osteogenesis, cranial anterior distraction, and maxillary arch expansion all produce orthopedic effects by applying external stress to stimulate suture distraction osteogenesis, and usually achieve a certain effect in a short period of time , but long-term follow-up observation shows that the recurrence rate after osteosynostosis is high, and the stability of the distraction effect needs to be...

AI Technical Summary

Problems solved by technology

[0006] 2. In the above methods, the arms on both sides of the spring need to be inserted into the cranial parietal bones on both sides to achieve good retention, but at the same time, a circular bone defect is formed in the parietal bone, which does not rule out the possibility that the cell activation mode is affected, resulting in the activation state of the suture.

[0007] 3. Manually bending single or hyperbolic springs for bow expansion, there are operational differences and errors, and the force cannot be accurately controlled, which affects the stability of the model

[0008] 4. Since the single-curvature or double-curvature stretching device exists between the skull and the scalp, the scalp cannot directly contact the skull, and the original physiological structure and environment cannot be reproduced. The impact on craniosynostosis research cannot be ruled out.

[0009] 5. Since the single-curvature or double-curvature stretching device exists inside the scalp, direct disassembly may cause damage to the scalp and the round hole of the skull, so it is not convenient to disassemble directly, and it is not suitable for the establishment of a recurrence model after stress stretching

Images