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Device and method for the delivery of a thrombin activated fibrin sealant

A fibrinogen and sealant technology, applied in biochemical equipment and methods, peptide/protein components, enzymes, etc., can solve problems such as interference with activity and damage to sealant functions

Pending Publication Date: 2021-09-24
GAMBRO LUNDIA AB
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the system described therein requires further development, as the dispenser may interfere with the activity of the individual components, compromising the sealant function

Method used

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  • Device and method for the delivery of a thrombin activated fibrin sealant
  • Device and method for the delivery of a thrombin activated fibrin sealant
  • Device and method for the delivery of a thrombin activated fibrin sealant

Examples

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Embodiment Construction

[0091] The invention relates to a dispenser of a sealant for hemostasis comprising a container for receiving a fibrinogen solution and an activation chamber on which a coagulation factor, preferably thrombin, is immobilized. The invention also relates to carriers for activation chambers, replaceable tips including activation chambers, and methods and kits for producing and dispensing sealants.

[0092] As is evident from the data presented here, immobilization of coagulation factors on functionalized supports in the activation chamber allows for the distribution of efficiently polymerized fibrin as a sealant while minimizing the release of coagulation factors to the site of deposition.

[0093] The present invention has the following advantages over conventional dispensers: The dispenser, assembly, method and kit of the present invention dispenses sealant quickly, easily, reliably and precisely to the desired location, particularly for hemostasis.

[0094] As used herein, "hem...

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Abstract

The invention relates to a dispenser of a sealant for hemostasis comprising a container configured to receive a fibrinogen solution and an activation compartment being situated downstream of the container and comprising a functionalized support to which a coagulation factor, preferably thrombin, is immobilized, such that upon dispensing the fibrinogen solution it passes through the activation compartment, thereby generating and dispensing polymerizing fibrin as a sealant. The invention further relates to a support, exchangeable tip and a kit for the dispenser as well as to methods and uses of the dispenser or components thereof for dispensing a sealant to a desired site.

Description

technical field [0001] The present invention relates to a dispenser of a sealant for hemostasis comprising a container configured to receive a fibrinogen solution and an activation chamber downstream of the container containing a functionalized carrier on which coagulation factors, preferably thrombin, are immobilized. The carrier is such that when the fibrinogen solution is dispensed, it passes through the activation chamber, thereby producing and dispensing polymerized fibrin as a sealant. The invention also relates to a carrier, a replaceable tip and a kit for a dispenser, as well as a method for dispensing a sealant to a desired location and the use of a dispenser or an assembly thereof for dispensing a sealant to a desired location. Background technique [0002] Fibrin sealants are typical surgical hemostats derived from plasma coagulation proteins. Fibrin sealants are widely used in various surgical procedures to control bleeding, and their use has increased due to th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B17/00A61K38/36A61K38/48A61L24/10
CPCA61B17/00491A61B2017/00495A61B2017/00526A61K38/363A61M5/3145C12Y304/21005A61L24/0036A61L24/043A61M5/19A61M5/31505
Inventor 扬·斯瓦特杰斯斯蒂芬妮·沃特勒马库斯·施托尔贝恩德·克劳泽
Owner GAMBRO LUNDIA AB
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