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Compound composition for lipid metabolism and prevention and treatment of fatty liver

A lipid metabolism, fatty liver technology, applied in the direction of drug combination, pharmaceutical formula, plant raw materials, etc., to achieve the effect of less side effects and obvious curative effect

Pending Publication Date: 2021-10-12
YUNNAN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the use of this formula for the regulation of lipid metabolism and the prevention and treatment of NAFLD has not been reported yet.

Method used

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  • Compound composition for lipid metabolism and prevention and treatment of fatty liver
  • Compound composition for lipid metabolism and prevention and treatment of fatty liver
  • Compound composition for lipid metabolism and prevention and treatment of fatty liver

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A compound composition for lipid metabolism and prevention and treatment of fatty liver, characterized in that it is composed of Polygonatum and Angelica in a ratio of 1:1;

[0029] Preferably, the Rhizoma Rhizoma Polygonatum needs to be processed, and then make a compound extract with Angelica Sinensis in a ratio of 1:1 for subsequent use;

[0030] Preferably, the processing method of described Rhizoma Polygonatum comprises the following steps:

[0031] 1) Remove the root hairs of the fresh Polygonatum, wash, cut into thick slices, and dry;

[0032] 2) Polygonatum and yellow rice wine are in the ratio of 5:1, use yellow rice wine to moisten until stuffy, use a steam sterilizer to steam at a temperature of 121°C, steam for 4 hours, and simmer for 3 hours;

[0033] 3) Take it out and dry it at 50°C.

[0034] Preferably, the preparation method of the compound extract is:

[0035] 1) The processed sealwort and angelica are evenly ground into fine powder, and the pulveri...

Embodiment 2

[0041] On the basis of Example 1, Polygonatum, Angelica, and Radix Astragali were mixed in a ratio of 1:1:1 to form Compound II; the processing and preparation methods of the compound extract were the same as in Example 1.

Embodiment 3

[0043] The intervention effect of the compound composition of the present invention on high-fat diet-induced NAFLD rats;

[0044] 1. Experimental materials: Rhizoma Rhizoma Rhizoma Rhizoma Polygonatum was selected from a professional farmers cooperative for planting medicinal materials in Wenshan, and the rest of the medicinal materials were purchased from the wholesale market of Chinese medicinal materials;

[0045] 2. Experimental animals: 150 8-week-old clean Spraque-Dawley healthy male rats, weighing 200±20g, purchased from Chengdu Dashuo Experimental Animal Co., Ltd., quality certificate number: SCXK (Sichuan) 2015-030. The experimental conditions and methods have passed the ethical review of the Animal Experiment Center of Yunnan University of Traditional Chinese Medicine, and the animal ethics review document number is: R-06201966. Before the experiment, all rats were fed adaptively for 1 week. During the adaptive feeding period, the animals had free access to food and ...

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Abstract

The invention discloses a compound composition for lipid metabolism and prevention and treatment of fatty liver, which is characterized that the compound composition is formed by combining rhizoma polygonati and Chinese angelica according to a ratio of 1: 1. The rhizoma polygonati has the activities of regulating blood fat, regulating immunity, resisting aging and the like, the Chinese angelica has the activities of enhancing hematopoietic function, reducing blood fat, resisting thrombus, enhancing immunity and the like and is also used for preventing and treating lipid metabolism disorder diseases, and in addition, the nine-times refined rhizoma polygonati pills have the effects of resisting aging, resisting inflammation, enhancing immunity, enhancing bone marrow hematopoietic function, regulating glycolipid metabolism disorder and the like; therefore, the rhizoma polygonati and the Chinese angelica are compounded according to the ratio of 1: 1, and the compound can be used for regulating lipid metabolism and preventing and treating the non-alcoholic fatty liver disease.

Description

technical field [0001] The invention belongs to the technical field of fatty liver prevention and treatment drugs, in particular to a compound composition for lipid metabolism and prevention and treatment of fatty liver. Background technique [0002] Non-alcoholic fatty liver disease (NAFLD) is mostly related to factors such as addiction to fat, sweet and delicious food, love of leisure and loathing work, emotional distress, insufficient congenital endowment, and untreated other diseases. These factors cause liver depression and spleen deficiency, kidney qi deficiency, phlegm turbidity and blood stasis Intrinsic accumulation, then sends out primary disease. The location of the disease is in the liver, involving spleen, stomach, kidney and other viscera. [0003] Modern studies have shown that Polygonatum has activities such as regulating blood lipids, regulating immunity, and anti-aging. Angelica has activities such as enhancing hematopoietic function, lowering blood lipids...

Claims

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Application Information

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IPC IPC(8): A61K36/8969A61P1/16A61K36/232
CPCA61K36/8969A61K36/232A61P1/16A61K2236/10A61K2236/333A61K2236/39A61K2236/51A61K2300/00
Inventor 杨兴鑫俞捷郝俊杰李艳芹张美张范顾雯李学芳余莉萍李艳娟字磊何旭东
Owner YUNNAN UNIV OF TRADITIONAL CHINESE MEDICINE
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