Daphnoretin micelle and preparation method, content detection and application thereof

Abstract

The invention relates to a daphnoretin micelle and a preparation method, content detection and application thereof. The daphnoretin nano-micelle is prepared by selecting a safe and degradable material PEG-PLA, and daphnoretin is prepared into a polymer micelle so as to achieve the purposes of increasing solubility and prolonging in-vivo action time. Meanwhile, the glycyrrhetinic acid coupled PEG-PLA is used as a carrier, and the nano preparation which is loaded with daphnoretin and has the liver cancer targeting property is prepared. Through in-vitro cell research, in-vivo targeting evaluation and preliminary pharmacodynamic research on the two drug-loaded micelles, the liver targeting drug delivery performance and the anti-tumor effect of the daphnoretin nano-micelle drug system are proved, and a theoretical basis is laid for in-vivo liver cancer targeting research of daphnoretin in the future; and a new thought is provided for the development of a new daphnoretin dosage form and a novel liver cancer targeting preparation.

Description

technical field [0001] The invention belongs to the technical field of drug development and analysis, and specifically relates to a sirutin micelle, a preparation method, content detection, in vivo and in vitro evaluation and application. Background technique [0002] Liver cancer is one of the malignant tumors that seriously threaten human life and health. The most common histopathological type is hepatocellular carcinoma (HCC), accounting for about 70% to 85% of all cases, followed by intrahepatic cholangiocarcinoma (ICC). , accounting for about 10 to 20%. According to the latest global cancer data in 2018, the incidence of liver cancer ranks fourth among malignant tumors, and the death rate ranks sixth. The annual number of new cases and deaths reaches 840,000 and 780,000 respectively, and the incidence rate is steadily increasing , a huge burden on people. Finding effective cancer drugs has become an urgent mission of the medical community, and has been working hard fo...

AI Technical Summary

Problems solved by technology

At present, the research on sipratin at home and abroad is mainly focused on the biological activity. However, sipratin has low solubility in water, poor absorption in the body, and poor targeting,

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