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Method for rapidly extracting sulforaphane from broccoli seeds

A technology for broccoli seeds and sulforaphane, which is applied in the directions of organic chemistry, fermentation, etc., can solve the problems of complex extraction method of sulforaphane, poor extract activity, excessive use of organic reagents, etc. Simple production equipment and consumables with good properties

Pending Publication Date: 2021-10-19
JING BRAND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to propose a method for quickly extracting sulforaphane from broccoli seeds, so as to solve the problems of complex extraction methods of sulforaphane, excessive use of organic reagents and poor activity of extracts

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Crush and sieve: Take a certain amount of broccoli seeds, grind them with a grinder, stop for 10 seconds after every 15 seconds of crushing, a total of 3 rounds, pass through a 25-mesh sieve after crushing, and then get the broccoli seed powder raw material;

[0024] Extraction: Weigh 50g broccoli seed sieve powder, add 15 times the volume of 20% ethanol solution, 750mL each time, extract in water bath at 40°C for 2 hours, extract twice in total, filter after extraction, collect and combine the filtrate;

[0025] Concentration: Concentrate the filtrate on a rotary evaporator to remove ethanol, the temperature of the water bath is 52°C, the vacuum degree is 0.1Mpa, and concentrate until the solid content is about 20%;

[0026] Drying: The concentrated juice was freeze-dried to obtain 10.55 g of broccoli seed extract.

Embodiment 2

[0028] Crush and sieve: Take a certain amount of broccoli seeds, grind them with a grinder, stop for 10 seconds after every 15 seconds of crushing, a total of 3 rounds, pass through a 25-mesh sieve in the Pharmacopoeia after crushing, and obtain the broccoli seed powder raw material;

[0029] Extraction: Weigh 60g broccoli seed sieve powder, add 17.5 times the volume of 15% ethanol solution, 1050mL each time, extract in a water bath at 30°C for 2.5h, extract twice in total, filter after extraction, collect and combine the filtrates, Determine the content of sulforaphane and calculate the extraction rate of sulforaphane in broccoli seeds to be 1.60%;

[0030] Concentration: Concentrate the filtrate on a rotary evaporator to remove ethanol, the temperature of the water bath is 56°C, the vacuum degree is 0.1Mpa, and concentrate until the solid content is about 16%;

[0031] Drying: The concentrated juice was freeze-dried to obtain 13.12 g of broccoli seed extract.

Embodiment 3

[0033] Crush and sieve: Take a certain amount of broccoli seeds, grind them with a grinder, stop for 10 seconds after every 15 seconds of crushing, a total of 3 rounds, pass through a 25-mesh sieve in the Pharmacopoeia after crushing, and obtain the broccoli seed powder raw material;

[0034] Extraction: Weigh 50g of broccoli seed powder, add 20 times the volume of 25% ethanol solution, 1000mL each time, extract in a water bath at 35°C for 1 hour, extract twice in total, filter after extraction, collect and combine the filtrates, and measure Calculation of sulforaphane content The extraction rate of sulforaphane in broccoli seeds was 1.64%;

[0035] Concentration: Concentrate the filtrate on a rotary evaporator to remove ethanol, the temperature of the water bath is 55°C, the vacuum degree is 0.1Mpa, and concentrate until the solid content is about 22%;

[0036] Drying: The concentrated juice was freeze-dried to obtain 11.02 g of broccoli seed extract.

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Abstract

The invention relates to a method for rapidly extracting sulforaphane from broccoli seeds. The method adopts a dilute ethanol solution as a solvent, and optimizes enzymolysis and extraction or extraction into one step on the basis of a traditional two-step method. Compared with two-step or other extraction methods, the one-step direct extraction method has the advantages of simpler process, fewer steps, environment-friendly reagents, convenience in operation and the like. Due to the active function of the sulforaphane and the guarantee of plant extraction, a green process and a green reagent, the sulforaphane has wide research and application values for developing health care products or foods with the effects of regulating organisms, resisting cancers and the like.

Description

technical field [0001] The invention belongs to the field of extraction and separation of natural active ingredients, and relates to a method for quickly extracting and preparing an extract containing active ingredients from broccoli seeds. Background technique [0002] Sulforaphane is an isothiocyanate (Sulforaphane, molecular formula C 6 h 11 NOS 2 ), obtained from the hydrolysis of glucosinolates (Glucosinlates) by myrosinase enzyme in plants. Sulforaphane is abundant in cruciferous plants such as broccoli, kale, and northern round carrots. It is a common antioxidant and one of the plant active substances with the best anti-cancer effects found in vegetables. [0003] Sulforaphane (SF) is one of the industry-recognized natural products with the best anti-cancer and anti-cancer effects found in vegetables so far. It not only has strong anti-cancer and anti-cancer activity, but also has anti-oxidation and immune regulation. good effect. Research data show that sulforap...

Claims

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Application Information

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IPC IPC(8): C12P13/00C07C331/20
CPCC12P13/00C07C331/20
Inventor 唐万石万银陈志超周俊强徐剑杨跃军
Owner JING BRAND