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Ciprofloxacin hydrochloride suppository and preparation method thereof

A technology for ciprofloxacin hydrochloride and suppositories, which is applied in the field of ciprofloxacin hydrochloride suppositories and its preparation, can solve the problems of many types of substrates and low bioavailability of ciprofloxacin hydrochloride suppositories, and achieve simple composition and irritating small effect

Inactive Publication Date: 2021-10-22
HAINAN HUIYUANTANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the bioavailability of the ciprofloxacin hydrochloride suppository prepared by using this matrix is ​​not high in the organism, and the required matrix types are many

Method used

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  • Ciprofloxacin hydrochloride suppository and preparation method thereof
  • Ciprofloxacin hydrochloride suppository and preparation method thereof
  • Ciprofloxacin hydrochloride suppository and preparation method thereof

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Embodiment 1

[0029] (1) Prescription

[0030] Table 1 Ciprofloxacin Hydrochloride Suppository Prescription

[0031] Raw materials Dosage for 1000 capsules (g) pre-processing Ciprofloxacin Hydrochloride 222.33 N / A polyethylene glycol 4000 1084 200 mesh filter after melting polyethylene glycol 400 351.5 200 mesh filter glycerin 80.33 200 mesh filter purified water 62 N / A

[0032] (2) Preparation process

[0033] Add polyethylene glycol 4000 and polyethylene glycol 400 into the matrix tank, heat at 80±5°C, and after most of the solid matrix melts, start stirring to completely melt the solid matrix at a stirring speed of 1000r / min; then add glycerin, Purified water, continue stirring for 15-20 minutes. Add the prescribed amount of ciprofloxacin hydrochloride, the main stirring blade is 30-35r / min, and the rapid stirring is 2800-3000r / min for 20 minutes. Vacuumize the main tank to a vacuum degree of -0.06Pa; start stirring; stir for 15...

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Abstract

The invention relates to the technical field of pharmaceutical preparations, in particular to a ciprofloxacin hydrochloride suppository and a preparation method thereof. The ciprofloxacin hydrochloride suppository is prepared from the following raw and auxiliary materials in parts by weight: 200 to 250 parts of ciprofloxacin hydrochloride; 500 to 2000 parts of polyethylene glycol 4000; 200 to 500 parts of polyethylene glycol 400; 50 to 200 parts of glycerol; and 10 to 100 parts of water. The ciprofloxacin hydrochloride suppository has the technical effects that the ciprofloxacin hydrochloride suppository is simple in composition and small in irritation, and the compliance of a patient can be improved.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a ciprofloxacin hydrochloride suppository and a preparation method thereof. Background technique [0002] Fluoroquinolones have achieved great success in clinical anti-infection therapy due to their high-efficiency, broad-spectrum, and low-toxic antibacterial properties. Ciprofloxacin hydrochloride is an excellent variety among fluoroquinolones developed by Bayer AG in 1981. [0003] Ciprofloxacin hydrochloride, chemical name is 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-(1-piperazinyl)-3-quinolinecarboxylate hydrochloride, molecular formula for C 17 h 18 FN 3 o 3 HCL, with a molecular weight of 385.82, has broad-spectrum antibacterial activity, especially high antibacterial activity against aerobic Gram-negative bacilli, and has good antibacterial activity against the following bacteria in vitro: most bacteria of the Enterobacteriaceae family, including Ci...

Claims

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Application Information

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IPC IPC(8): A61K9/02A61K31/496A61K47/10A61P31/04
CPCA61K31/496A61K9/02A61K47/10A61P31/04
Inventor 徐朗沈晨陈容徐扬方方杨尚志
Owner HAINAN HUIYUANTANG PHARMA
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