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Kimchi lactobacillus sakei having prophylactic, ameliorating or therapeutic effect on depression and anxiety disorders

A technology of Lactobacillus sack, depression, applied in the directions of Lactobacillus, medical preparations containing active ingredients, bacteria used in food preparation, etc., can solve the problem of no lactobacillus found

Inactive Publication Date: 2021-10-26
KOREA FOOD RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] In this context, the use of lactic acid bacteria has recently been studied for the prevention and treatment of Parkinson's disease. However, except for constipation, lactic acid bacteria that directly affect the symptoms of Parkinson's disease, such as ataxia, depression, or anxiety, have not been found. Therefore, there is a need to develop lactic acid bacteria capable of improving or treating ataxia, depression or anxiety caused by Parkinson's disease

Method used

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  • Kimchi lactobacillus sakei having prophylactic, ameliorating or therapeutic effect on depression and anxiety disorders
  • Kimchi lactobacillus sakei having prophylactic, ameliorating or therapeutic effect on depression and anxiety disorders
  • Kimchi lactobacillus sakei having prophylactic, ameliorating or therapeutic effect on depression and anxiety disorders

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0073] Embodiment 1: Preparation of culture solution of Lactobacillus sarkeri WIKIM31 strain

[0074] In the experiment, a strain of Lactobacillus sakeiWIKIM31 (Lactobacillus sakeiWIKIM31) derived from kimchi deposited at the Korean Microorganism Collection under deposit numbers KFCC11654P (domestic deposit) and KCCM12654P (international deposit) was used. After culturing Lactobacillus sarkeri WIKIM31 strain in MRS medium at a temperature of 30°C for 24 hours, centrifuge at 8000 rpm for 5 minutes, and rinse with PBS to remove residual medium components. 1 x 10 in PBS 10 The number of bacteria in CFU / mL was quantified, and 0.2 mL (1×10 9 CFU), sterile PBS was administered to the negative and positive control groups.

Embodiment 2

[0075] Example 2: Confirmation of Depression and Anxiety Symptom Prevention or Improvement Effects in Animal Models

[0076] Eight-week-old male mice (C57BL / 6) were acclimatized in a breeding room for one week, and Lactobacillus sakei WIKIM31 (Lactobacillus sakei WIKIM31, KFCC11654P) was orally administered for 30 days. Afterwards, after induction of Parkinson's disease by intraperitoneal injection of MPTP (1-methyl-4-phenyl-1,2,3,6-te trahydropyridine), the effect of Lactobacillus sarkeri WIKIM31 was confirmed, as shown in figure 1 and figure 2 shown. At this time, at figure 1 and figure 2 Among them, Naive is a normal mouse model, MPTP is a mouse model of Parkinson's disease induced by oral administration of PBS, and WIKIM31 is a mouse model of Parkinson's disease induced by oral administration of Lactobacillus sarkeri WIKIM31.

[0077] To evaluate anxiety symptoms in animal models of Parkinson's disease, an open field analysis was performed. The purpose of the open f...

Embodiment 3

[0079] Example 3: Confirmation of Depression and Anxiety Symptom Prevention or Improvement Effects in Normal Animal Models

[0080] 3-1. Induction of depression in normal animal model

[0081] After making 6-week-old male rats (Rat, Sprague Dawley) adapt to the feeding room for one week, chronic stress was applied from the 7-week-old, and the experimental animals were randomly given water or feed, provided empty water bottles, Reversal of circadian cycle, flashing lights, periodic noise, provision of wet bedding, tilting of cage, provision of restraint stress, etc. The total induction period was 6 weeks, and different stresses were applied every day. In the first two weeks, only stress was applied without ingestion of Lactobacillus sakei WIKIM31 to induce depression. It was measured whether or not depression was improved by ingesting Lactobacillus sakei WIKIM31 (Lact obacillus sakei WIKIM31, KCCM12654P) simultaneously with stress.

[0082] 3-2. Analysis of blood corticostero...

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Abstract

The present invention relates to a composition for the prevention, alleviation, or treatment of depression or anxiety disorders, comprising Lactobacillus Sakei as an active ingredient. The strain of Lactobacillus Sakei according to the present invention can be utilized for the prevention, improvement, and treatment of mental disorders such as depression or anxiety disorders.

Description

technical field [0001] The present invention relates to Lactobacillus sakei which has the effect of preventing, improving or treating depression and anxiety. Background technique [0002] As society becomes more and more complex, modern people are under a lot of pressure. As a result, the number of people suffering from mental illnesses such as depression, anxiety, and sleep disorders caused by various stresses has increased dramatically. [0003] Unable to cope with this stress and let it go, it can lead to psychological reactions such as depression, restlessness, fatigue, anger, mood changes, etc., and lead to physiological reactions such as increased blood pressure, rapid pulse, etc. If these reactions occur repeatedly, there will be Such as depression, anxiety, sleep disorders and other diseases, and cause personal, family and social losses, reduce personal quality of life. [0004] Among the disorders caused by depression, depression refers to a depressed mental state...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/135A61P25/24A61P25/22A61K35/747
CPCA61K35/747A61P25/24A61P25/22A23L33/135A23V2002/00A23V2200/3204A23V2200/322A23V2400/179C12R2001/225
Inventor 崔鹤钟金男熙朴孝敬李知恩
Owner KOREA FOOD RES INST
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