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Application of golden tea volatile oil in the preparation of LPS-induced acute lung injury protection medicine

An acute lung injury and volatile oil technology is applied in the application field of golden tea volatile oil in the preparation of LPS-induced acute lung injury protective drugs, and the effects of down-regulation, improvement of lung tissue pathological damage, and good prospect value are achieved.

Active Publication Date: 2022-04-12
NANCHANG UNIV
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  • Abstract
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But there is no report about the effect of volatile oil of golden tea on LPS-induced acute lung injury

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  • Application of golden tea volatile oil in the preparation of LPS-induced acute lung injury protection medicine
  • Application of golden tea volatile oil in the preparation of LPS-induced acute lung injury protection medicine
  • Application of golden tea volatile oil in the preparation of LPS-induced acute lung injury protection medicine

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Embodiment Construction

[0026] Below in conjunction with accompanying drawing, the present invention will be further described.

[0027] 1. Experimental materials

[0028] 1.1 Materials and reagents

[0029] Golden tea is prepared from the young leaves of Waxweed cultivated and collected by professional cooperatives in Wuyuan County, Jiangxi Province. The extraction of the volatile oil of golden tea is obtained by the following method: Weigh 600g of golden tea. Soak in ultrapure water (1:40, w / v), treat with microwave for 10 minutes, extract by steam distillation for 5 hours, add anhydrous sodium sulfate, and dry to obtain golden tea volatile oil, which is stored in a refrigerator at 4°C. The volatile oil of golden tea is mainly esters and terpenoids, of which the content of (1-methyl-4-prop-1-en-2-ylcyclohexyl) acetate reaches 50.67%, followed by α-pinene (6.92 %), α-terpinyl acetate (5.77%), epoxidized humulene II (3.96%), pseudolimonene (3.21%), D-birgerene (3.12%), etc.

[0030] LPS (US Sigma...

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Abstract

The invention discloses the application of golden tea volatile oil in the preparation of LPS-induced acute lung injury protection medicine, and belongs to the technical field of medical applications. The invention uses experimental means to investigate the protective effect of golden tea volatile oil on lipopolysaccharide (LPS)-induced acute lung injury. The volatile oil of golden tea significantly improved LPS-induced lung pathological damage; and further confirmed that its pharmacological effect is through restoring the reduction of white blood cells caused by LPS, reducing the degree of thymus and spleen enlargement, down-regulating the level of serum pro-inflammatory factors, and enhancing antioxidant capacity. Defense ability and increased content of short-chain fatty acids. Based on the above new properties of the volatile oil of golden tea, the present invention determines the new application of using it to prepare a medicine for protecting acute lung injury induced by LPS.

Description

technical field [0001] The invention belongs to the technical field of medical applications, and further relates to new medical applications of substances, in particular to the application of golden tea volatile oil in the preparation of LPS-induced acute lung injury protection drugs. Background technique [0002] In recent years, due to the aggravation of air pollution and the change of human living habits, the incidence of acute lung injury has been increasing year by year. The incidence rate is about 34 / 100,000, and the mortality rate is about 34%-58%. Acute lung injury is an uncontrolled inflammatory disease characterized by acute inflammation of the lungs, and is a complication of critical illnesses such as sepsis and severe trauma. Lipopolysaccharide (LPS), a major component of the cell wall of Gram-negative bacteria, is a common cause of acute lung injury. Therefore, in this technique, a rat model of acute lung injury is established by intraperitoneal injection of LP...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/185A61P11/00A61P29/00A61K127/00
CPCA61K36/185A61K9/0053A61P11/00A61P29/00
Inventor 李文娟万敏姚于飞桑婷卿城吴伟潘雨欣
Owner NANCHANG UNIV
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