Preparation device of microcrystalline cellulose pellet core

Abstract

The invention belongs to the technical field of medicine, and particularly relates to a preparation device of a microcrystalline cellulose pellet core, which comprises a rotating ring and a fixed ring; the rotating ring is arranged above the fixed ring; a fixed frame is connected to the rotating ring; a hollow pipe is arranged in the fixed frame and can be used for containing a device; the rotating ring can rotate under the action of the fixed frame; an injection mechanism and a shaping mechanism are respectively arranged on the rotating ring and the fixed ring; the injection mechanism and the shaping mechanism correspond to each other and are matched with each other; the injection mechanism is communicated with external microcrystalline cellulose pill slurry through the hollow pipe; and meanwhile, the injection mechanism can move up and down on the rotating ring. The invention has the advantages that: microcrystalline cellulose pellet cores can be manufactured in different moulds in an infinite circulation mode; meanwhile, operation of other batches is not affected; high efficiency is achieved; pellet bodies can be manufactured without intervention of a pellet rolling machine; and cracking is not prone to being caused during drying.

Description

Technical field [0001] The present invention belongs to the field of medical technology, particularly relates to a process for preparing apparatus microcrystalline cellulose pellet core. Background technique [0002] Microcrystalline cellulose pellets by pharmaceutical excipients is actually a growing number of new pharmaceutical formulations demonstrated in front of consumers, while domestic pharmaceutical enterprises to obtain materials and function under the premise of continuous improvement in the process and equipment We made a lot of new requirements, microcrystalline cellulose pellet cores, too, has been widely used in slow-release capsules, tablets pellets, the production steps are usually: microcrystalline cellulose cake was mechanically treated, and dried to remove micro accounting cake moisture by weight of microcrystalline cellulose, [0003] After drying the filter cake was added microcrystalline cellulose extrusion spheronization spheronization machine, after drying...

AI Technical Summary

Problems solved by technology

[0004] In the process of spheronizing microcrystalline cellulose slurry, it needs to undergo multiple evaporations, thereby changing the properties of its fluid, so as to facilitate spheronization, and because the spheronization is in the form of pellets, there is still a lot of water inside, so in the subsequent evaporation process, Part of the ball rolling will cause local cracking and damage. At the same time, due to the difficulty in volume control, subsequent screening is required to select the required diameter. The process is lengthy and inefficient.

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