Full-automatic sterile connection reactor sampling unit

Abstract

The invention relates to the technical field of biological medicine production, and particularly relates to a full-automatic sterile connection reactor sampling unit. The full-automatic sterile connection reactor sampling unit comprises a unit mounting bottom plate, wherein a peristaltic pump is mounted on the left upper side of the front surface of the unit mounting bottom plate; sampling pipelines are mounted on the front surface of the unit mounting bottom plate and are positioned on two sides of the peristaltic pump; an electromagnetic valve is mounted on the front surface of the unit mounting bottom plate and is positioned on the right side of the peristaltic pump; a sampling needle is mounted on the front surface of the unit mounting bottom plate and is positioned on the lower side of the electromagnetic valve; a pipe clamp is mounted on the left upper side of the front surface of the unit mounting bottom plate; a one-way valve is mounted on the left side of the front surface of the unit mounting bottom plate and corresponds to the sampling pipelines; a reactor tank connector is mounted on the left lower side of the front surface of the unit mounting bottom plate; a liquid storage bottle is arranged on the lower side of the front surface of the unit mounting bottom plate; and an air filter is mounted on the left side of an end of the liquid storage bottle. The full-automatic sterile connection reactor sampling unit is simple in integral structure, and data of a whole process can be acquired and stored.

Description

technical field [0001] The invention relates to the technical field of biopharmaceutical production, in particular to a fully automatic aseptic connection reactor sampling unit. Background technique [0002] In the process of using bioreactors for biopharmaceutical production and cell culture experiments, sampling from tanks has a high operating frequency. Usually, each tank needs to be sampled once or more times a day to check the cells and environment in each tank. For detection, the detection items include pH value, cell viability, cell number, medium osmotic pressure, sugar, lactic acid, amino acid and various ion contents that affect cell growth. The appropriate and reliable automatic sampling mode can directly affect the sample detection results The accuracy and reliability of the whole production process. At present, in the front-line R&D and production process, manual syringe sampling operation mode is widely and widely used, which leads to high personnel cost and lo...

AI Technical Summary

Problems solved by technology

[0002] In the process of using bioreactors for biopharmaceutical production and cell culture experiments, sampling from tanks has a high operating frequency. Usually, each tank needs to be sampled once or more times a day to check the cells and environment in each tank. For detection, the detection items include pH value, cell viability, cell number, medium osmotic pressure, sugar, lactic acid, amino acid and various ion contents that affect cell growth. The appropriate and reliable automatic sampling mode can directly affect the sample detection results The accuracy and reliability of the whole production process. At present, in the front-line R&D and production process, manual syringe sampling operation mode is widely and widely used, which leads to high personnel cost and low operation efficiency. In addition, the stability and safety of manual operation It is also difficult to guarantee the reliability, so there is a need for a fully automatic aseptic connection reactor sampling unit to improve the above problems

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