Persistent adhesion type periodontal plug treatment agent and preparation method thereof

Abstract

The invention relates to a persistent adhesion type periodontal occlusion treatment agent and a preparation method thereof. The persistent adhesion type periodontal occlusion treatment agent comprises mussel mucin, a hydrophilic polymer, a hydrophobic polymer, a diluent and a plasticizer, in parts by weight, the content of the mussel mucin is 4 to 20 parts, the content of the hydrophilic polymer is 28 to 40 parts, the content of the hydrophobic polymer is 23 to 45 parts, the content of the diluent is 6 to 15 parts, and the content of the plasticizer is 4 to 12 parts. The persistent adhesion type periodontal occlusion treatment agent has adhesion and durability, is long in dissolution time, soft and plastic, can adapt to complex conditions of the oral cavity, and can adhere to the wound surface of the oral cavity more enduringly to effectively adhere and seal the affected part; the persistent adhesion type periodontal occlusion treatment agent is suitable for protecting postoperative wounds of oral surgery, periodontal surgery or maxillofacial surgery, and effectively obstructs stimulating factors in the external environment.

Description

technical field [0001] The invention relates to the technical field of oral care, in particular to a durable adhesive periodontal plug and a preparation method thereof. Background technique [0002] Periodontal disease refers to diseases that occur in periodontal supporting tissues, including gingival disease involving gingival tissue and periodontitis involving deep periodontal tissue. The main way to treat periodontal disease is to eliminate and reduce local pathogenic microorganisms, restore the damaged periodontal support tissue as much as possible and maintain its health. After the periodontal disease develops to a more serious stage, basic treatment alone cannot solve all the problems. It is necessary to treat the periodontal soft and hard tissues through surgery in order to obtain good curative effect. [0003] In periodontal surgery, periodontal plugs can protect the wound surface from secondary damage, stop bleeding, fix loose teeth and soft tissues, protect expose...

AI Technical Summary

Problems solved by technology

[0005] The periodontal plug treatment agent containing zinc oxide and eugenol is a two-component, the powder and the liquid are used after reconciliation. After curing, it will cause discomfort and foreign body sensation to the patient, and its composition contains clove oil, which has certain toxic and side effects. It can cause allergic reactions, etc., and is gradually eliminated by the market;

[0006] Periodontal plugs that contain zinc oxide but do not contain eugenol are also two-component, which need to be mixed before use. It is difficult to remove after curing, and it is easy to cause pressure sores on the wound surface, affecting wound healing;

[0007] The periodontal plug treatment agent without zinc oxide and eugenol is a single-component, a new type of single-component material developed in recent years. It is mostly prepared by blending hydrophilic materials and hydrophobic materials. It is easy to use and does not require photocuring. It is soft, not easy to cause pressure sores, and can dissolve with saliva without secondary removal, but its dissolution time is fast and its durability is poor. After dissolution, it is easy to expose the wound surface. The influence of bacteria, saliva and other stimulating factors will affect wound healing. Timely and frequent use

[0008] The periodontal suppository without zinc oxide and eugenol has the defects of fast dissolution time and poor durability. The root cause is that the components contain hydrophilic polymers with mucoadhesive properties such as carboxymethyl cellulose. This kind of material can continuously swell and dissolve with saliva, which will lead to the gradual disintegration of the periodontal plug in the oral cavity

[0009] If we simply increase the proportion of hydrophobic materials and reduce the proportion of hydrophilic materials for the root cause, although the dissolution time of the periodontal suppository can be prolonged and the durability can be improved, the mucoadhesiveness of the periodontal suppository will inevitably decrease, resulting in the loss of periodontal suppository. fall out in the mouth

To sum up, by adjusting the proportion of hydrophobic materials and hydrophilic materials, there is a problem that the adhesion and durability of periodontal plugs cannot be achieved at the same time.

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