Persistent adhesion type periodontal plug treatment agent and preparation method thereof

An adhesive and periodontal technology, applied in the field of oral care, can solve the problems of easily exposed wounds, poor durability, fast dissolution time, etc., and achieve the effect of prolonging the dissolution time, preventing saliva erosion, and prolonging the residence time.

Pending Publication Date: 2021-11-19
博纳格科技(天津)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The periodontal plug treatment agent containing zinc oxide and eugenol is a two-component, the powder and the liquid are used after reconciliation. After curing, it will cause discomfort and foreign body sensation to the patient, and its composition contains clove oil, which has certain toxic and side effects. It can cause allergic reactions, etc., and is gradually eliminated by the market;
[0006] Periodontal plugs that contain zinc oxide but do not contain eugenol are also two-component, which need to be mixed before use. It is difficult to remove after curing, and it is easy to cause pressure sores on the wound surface, affecting wound healing;
[0007] The periodontal plug treatment agent without zinc oxide and eugenol is a single-component, a new type of single-component material developed in recent years. It is mostly prepared by blending hydrophilic materials and hydrophobic materials. It is easy to use and does not require photocuring. It is soft, not easy to cause pressure sores, and can dissolve with saliva without secondary removal, but its dissolution time is fast and its durability is poor. After dissolution, it is easy to ex

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  • Persistent adhesion type periodontal plug treatment agent and preparation method thereof
  • Persistent adhesion type periodontal plug treatment agent and preparation method thereof
  • Persistent adhesion type periodontal plug treatment agent and preparation method thereof

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preparation example Construction

[0056] The present invention further provides a preparation method of a durable adhesive periodontal plug, comprising the following steps:

[0057] Put hydrophobic polymers, hydrophilic polymers, diluents, and plasticizers in a laboratory kneader, and after sealing, knead them to obtain a uniform paste;

[0058] Add mussel mucin to the obtained homogeneous paste, pre-flow nitrogen or vacuumize to avoid oxidation of mussel mucin, stir at 25°C and 100-200rpm for 30 minutes, and fill to obtain a finished product.

[0059] As one of the optional embodiments, the solid material is pulverized by a pulverizer and passed through a 40-mesh sieve.

Embodiment 1-2

[0060] The preparation method of the persistent adhesion type periodontal plug treatment agent described in embodiment 1-2, the steps are as follows:

[0061] Step 1, take the hydrophobic polymer solid material according to the proportion, crush it with a pulverizer, and pass it through a 40-mesh sieve;

[0062] Step 2, take hydrophilic macromolecule, diluent, plasticizer according to proportioning, put hydrophobic macromolecule, hydrophilic macromolecule, diluent, plasticizer in laboratory kneader, after airtight, and in Knead for 2 hours at 25°C and 200rpm to obtain a homogeneous paste with no visible particles in the homogeneous paste;

[0063] Step 3: Open the feeding port of the kneader, add mussel mucin according to the proportion, pre-flow nitrogen for 15 minutes, seal it, and stir at 25°C and 200rpm for 30 minutes before filling to obtain the finished product.

Embodiment 3-4

[0064] The preparation method of the persistent adhesion type periodontal plug treatment agent described in embodiment 3-4, the steps are as follows:

[0065] Step 1, take the hydrophobic polymer, diluent, and plasticizer according to the proportion, put the hydrophobic polymer, diluent, and plasticizer in the laboratory kneader, seal it, and under the conditions of 160°C and 100rpm, Kneading 2h;

[0066] Step 2, take the hydrophilic polymer according to the proportion, add it to the feed port of the kneader, seal it, and knead it at 95°C and 200rpm for 30min, stop heating, and continue stirring at 200rpm until it cools to room temperature;

[0067] Step 3, open the feeding port of the kneader, add mussel mucin according to the proportion, seal it, vacuumize it, stir it for 30 minutes at 25°C and 100 rpm, and fill it to obtain the finished product.

[0068] Compared with Example 1-2, the change of some process conditions in Example 3-4 is based on the consideration of diluent...

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Abstract

The invention relates to a persistent adhesion type periodontal occlusion treatment agent and a preparation method thereof. The persistent adhesion type periodontal occlusion treatment agent comprises mussel mucin, a hydrophilic polymer, a hydrophobic polymer, a diluent and a plasticizer, in parts by weight, the content of the mussel mucin is 4 to 20 parts, the content of the hydrophilic polymer is 28 to 40 parts, the content of the hydrophobic polymer is 23 to 45 parts, the content of the diluent is 6 to 15 parts, and the content of the plasticizer is 4 to 12 parts. The persistent adhesion type periodontal occlusion treatment agent has adhesion and durability, is long in dissolution time, soft and plastic, can adapt to complex conditions of the oral cavity, and can adhere to the wound surface of the oral cavity more enduringly to effectively adhere and seal the affected part; the persistent adhesion type periodontal occlusion treatment agent is suitable for protecting postoperative wounds of oral surgery, periodontal surgery or maxillofacial surgery, and effectively obstructs stimulating factors in the external environment.

Description

technical field [0001] The invention relates to the technical field of oral care, in particular to a durable adhesive periodontal plug and a preparation method thereof. Background technique [0002] Periodontal disease refers to diseases that occur in periodontal supporting tissues, including gingival disease involving gingival tissue and periodontitis involving deep periodontal tissue. The main way to treat periodontal disease is to eliminate and reduce local pathogenic microorganisms, restore the damaged periodontal support tissue as much as possible and maintain its health. After the periodontal disease develops to a more serious stage, basic treatment alone cannot solve all the problems. It is necessary to treat the periodontal soft and hard tissues through surgery in order to obtain good curative effect. [0003] In periodontal surgery, periodontal plugs can protect the wound surface from secondary damage, stop bleeding, fix loose teeth and soft tissues, protect expose...

Claims

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Application Information

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IPC IPC(8): A61K38/17A61K45/06A61K9/00A61L24/00A61L24/10A61P1/02A61P17/02
CPCA61K38/1767A61K45/06A61K9/0063A61K9/0014A61P1/02A61P17/02A61L24/108A61L24/0015
Inventor 陈辉王跃姜智旭李志军
Owner 博纳格科技(天津)有限公司
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