Persistent adhesion type periodontal plug treatment agent and preparation method thereof

Abstract

The invention relates to a persistent adhesion type periodontal occlusion treatment agent and a preparation method thereof. The persistent adhesion type periodontal occlusion treatment agent comprises mussel mucin, a hydrophilic polymer, a hydrophobic polymer, a diluent and a plasticizer, in parts by weight, the content of the mussel mucin is 4 to 20 parts, the content of the hydrophilic polymer is 28 to 40 parts, the content of the hydrophobic polymer is 23 to 45 parts, the content of the diluent is 6 to 15 parts, and the content of the plasticizer is 4 to 12 parts. The persistent adhesion type periodontal occlusion treatment agent has adhesion and durability, is long in dissolution time, soft and plastic, can adapt to complex conditions of the oral cavity, and can adhere to the wound surface of the oral cavity more enduringly to effectively adhere and seal the affected part; the persistent adhesion type periodontal occlusion treatment agent is suitable for protecting postoperative wounds of oral surgery, periodontal surgery or maxillofacial surgery, and effectively obstructs stimulating factors in the external environment.

Description

technical field

[0001] The invention relates to the technical field of oral care, in particular to a durable adhesive periodontal plug and a preparation method thereof. Background technique

[0002] Periodontal disease refers to diseases that occur in periodontal supporting tissues, including gingival disease involving gingival tissue and periodontitis involving deep periodontal tissue. The main way to treat periodontal disease is to eliminate and reduce local pathogenic microorganisms, restore the damaged periodontal support tissue as much as possible and maintain its health. After the periodontal disease develops to a more serious stage, basic treatment alone cannot solve all the problems. It is necessary to treat the periodontal soft and hard tissues through surgery in order to obtain good curative effect.

[0003] In periodontal surgery, periodontal plugs can protect the wound surface from secondary damage, stop bleeding, fix loose teeth and soft tissues, protect expose...

Examples

preparation example Construction

[0056] The present invention further provides a preparation method of a durable adhesive periodontal plug, comprising the following steps:

[0057] Put hydrophobic polymers, hydrophilic polymers, diluents, and plasticizers in a laboratory kneader, and after sealing, knead them to obtain a uniform paste;

[0058] Add mussel mucin to the obtained homogeneous paste, pre-flow nitrogen or vacuumize to avoid oxidation of mussel mucin, stir at 25°C and 100-200rpm for 30 minutes, and fill to obtain a finished product.

[0059] As one of the optional embodiments, the solid material is pulverized by a pulverizer and passed through a 40-mesh sieve.

Embodiment 1-2

[0060] The preparation method of the persistent adhesion type periodontal plug treatment agent described in embodiment 1-2, the steps are as follows:

[0061] Step 1, take the hydrophobic polymer solid material according to the proportion, crush it with a pulverizer, and pass it through a 40-mesh sieve;

[0062] Step 2, take hydrophilic macromolecule, diluent, plasticizer according to proportioning, put hydrophobic macromolecule, hydrophilic macromolecule, diluent, plasticizer in laboratory kneader, after airtight, and in Knead for 2 hours at 25°C and 200rpm to obtain a homogeneous paste with no visible particles in the homogeneous paste;

[0063] Step 3: Open the feeding port of the kneader, add mussel mucin according to the proportion, pre-flow nitrogen for 15 minutes, seal it, and stir at 25°C and 200rpm for 30 minutes before filling to obtain the finished product.

Embodiment 3-4

[0064] The preparation method of the persistent adhesion type periodontal plug treatment agent described in embodiment 3-4, the steps are as follows:

[0065] Step 1, take the hydrophobic polymer, diluent, and plasticizer according to the proportion, put the hydrophobic polymer, diluent, and plasticizer in the laboratory kneader, seal it, and under the conditions of 160°C and 100rpm, Kneading 2h;

[0066] Step 2, take the hydrophilic polymer according to the proportion, add it to the feed port of the kneader, seal it, and knead it at 95°C and 200rpm for 30min, stop heating, and continue stirring at 200rpm until it cools to room temperature;

[0067] Step 3, open the feeding port of the kneader, add mussel mucin according to the proportion, seal it, vacuumize it, stir it for 30 minutes at 25°C and 100 rpm, and fill it to obtain the finished product.

[0068] Compared with Example 1-2, the change of some process conditions in Example 3-4 is based on the consideration of diluent...

technical field

[0001] The invention relates to the technical field of oral care, in particular to a durable adhesive periodontal plug and a preparation method thereof. Background technique

[0002] Periodontal disease refers to diseases that occur in periodontal supporting tissues, including gingival disease involving gingival tissue and periodontitis involving deep periodontal tissue. The main way to treat periodontal disease is to eliminate and reduce local pathogenic microorganisms, restore the damaged periodontal support tissue as much as possible and maintain its health. After the periodontal disease develops to a more serious stage, basic treatment alone cannot solve all the problems. It is necessary to treat the periodontal soft and hard tissues through surgery in order to obtain good curative effect.

[0003] In periodontal surgery, periodontal plugs can protect the wound surface from secondary damage, stop bleeding, fix loose teeth and soft tissues, protect expose...

Examples

preparation example Construction

[0056] The present invention further provides a preparation method of a durable adhesive periodontal plug, comprising the following steps:

[0057] Put hydrophobic polymers, hydrophilic polymers, diluents, and plasticizers in a laboratory kneader, and after sealing, knead them to obtain a uniform paste;

[0058] Add mussel mucin to the obtained homogeneous paste, pre-flow nitrogen or vacuumize to avoid oxidation of mussel mucin, stir at 25°C and 100-200rpm for 30 minutes, and fill to obtain a finished product.

[0059] As one of the optional embodiments, the solid material is pulverized by a pulverizer and passed through a 40-mesh sieve.

Embodiment 1-2

[0060] The preparation method of the persistent adhesion type periodontal plug treatment agent described in embodiment 1-2, the steps are as follows:

[0061] Step 1, take the hydrophobic polymer solid material according to the proportion, crush it with a pulverizer, and pass it through a 40-mesh sieve;

[0062] Step 2, take hydrophilic macromolecule, diluent, plasticizer according to proportioning, put hydrophobic macromolecule, hydrophilic macromolecule, diluent, plasticizer in laboratory kneader, after airtight, and in Knead for 2 hours at 25°C and 200rpm to obtain a homogeneous paste with no visible particles in the homogeneous paste;

[0063] Step 3: Open the feeding port of the kneader, add mussel mucin according to the proportion, pre-flow nitrogen for 15 minutes, seal it, and stir at 25°C and 200rpm for 30 minutes before filling to obtain the finished product.

Embodiment 3-4

[0064] The preparation method of the persistent adhesion type periodontal plug treatment agent described in embodiment 3-4, the steps are as follows:

[0065] Step 1, take the hydrophobic polymer, diluent, and plasticizer according to the proportion, put the hydrophobic polymer, diluent, and plasticizer in the laboratory kneader, seal it, and under the conditions of 160°C and 100rpm, Kneading 2h;

[0066] Step 2, take the hydrophilic polymer according to the proportion, add it to the feed port of the kneader, seal it, and knead it at 95°C and 200rpm for 30min, stop heating, and continue stirring at 200rpm until it cools to room temperature;

[0067] Step 3, open the feeding port of the kneader, add mussel mucin according to the proportion, seal it, vacuumize it, stir it for 30 minutes at 25°C and 100 rpm, and fill it to obtain the finished product.

[0068] Compared with Example 1-2, the change of some process conditions in Example 3-4 is based on the consideration of diluent...

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