Composite medical biopolymer material and preparation method thereof

A biopolymer and macromolecule technology, applied in non-active ingredient medical preparations, pharmaceutical formulations, chemical instruments and methods, etc., can solve the problems of inaccurate control of the physical and chemical properties of polymer materials, price and preparation process. Does not have very good advantages, harsh reaction conditions and other problems, to achieve the effect of increasing the degradation half-life or dissolution time, excellent stability, and reaction temperature

Pending Publication Date: 2022-06-17
湖南益安生物科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The excellent properties of polymer materials have been widely used in medicine, but there are cumbersome processes and harsh reaction conditions in the preparation process, and

Method used

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  • Composite medical biopolymer material and preparation method thereof
  • Composite medical biopolymer material and preparation method thereof
  • Composite medical biopolymer material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0039]实施例一：

[0040]一种复合医用生物高分子材料的制备方法，其制备方法包括以下步骤：

[0041]第一步：称取可溶性甲壳素类高分子，氨基化透明质酸，去离子水，助溶剂按照按照一定比例放置在搅拌装置中形成混合溶液；

[0042]搅拌装置包括搅拌箱体，固定安装在所述搅拌箱体外部的输送泵，所述输送泵与所述搅拌箱体的底部之间通过导管相连通，每个所述导管与所述搅拌箱体的底部之间均设置有过滤网，所述搅拌箱体的内部同心设置有喷射机构及固定机构，所述固定机构与所述搅拌箱体之间固定连接，所述固定机构上还设置有刮板机构，所述喷射机构转动连接在所述搅拌箱体的内部，并且所述喷射机构的顶部与所述输送泵之间相连通，所述喷射机构与所述固定机构之间通过第一传动机构和第二传动机构之间传动连接；

[0043]第二步：通过驱动输送泵使搅拌装置中的混合溶液循环流动，利用混合溶液的流动冲击固定机构形成对喷射机构的反向推力带动所述喷射机构进行转，并在此过程中通过第一传动机构和第二传动机构的作用下推动刮板机构在搅拌装置的内部进行上下往复移动，充分搅拌后得到待加工产物；

[0044]所述固定机构包括固定连接在所述搅拌箱体内部的固定支架，所述固定支架的内表面均匀分布安装有弧形挡板，所述固定支架的两侧均转动连接有丝杆，所述固定支架上下滑动连接有刮板机构，两个所述丝杆均与所述刮板机构之间螺纹连接，所述固定支架的上下两侧均固定连接有斜齿环；

[0045]所述喷射机构包括转动连接在所述搅拌箱体上的导料管，所述导料管上固定连接有第一斜齿轮，所述导料管的下端固定连接有喷射支架，所述喷射支架的圆周方向上设置有喷射头，所述喷射头的喷射方向与所述导料管的径向方向之间具有夹角，所述喷射支架上下两端的两侧均转动连接有搅拌支架，每个所述搅拌支架在远离所述导料管的一端均固定连接有第二斜齿轮，所述第二斜齿轮与所述斜齿环之间传动连接；

[0046]所述第一传动机构包括转动连接在所述搅拌箱体上的传动转轴，所述传动转轴的两侧分别固定连接有第一传动轮与第三斜齿轮，所述第三斜齿轮与所述第一斜齿轮之间啮合连接；

[0047]所述第二传动机构包括滑动连接在所述搅拌箱体侧面的传动支架，所述传动支架与所述搅拌箱体之间设置有气缸，所述传动支架上转动连接有传动套筒，所述传动套筒套设在延伸出所述固定支架上端的所述丝杆上并与所述丝杆之间传动连接，所述传动套筒上固定连...

Example Embodiment

[0049]实施例二：

[0050]一种复合医用生物高分子材料的制备方法，基于实施例一，不同的是在第一步；

[0051]称取可溶性甲壳素类高分子，阳离子透明质酸，去离子水，助溶剂按照按照一定比例放置在搅拌装置中形成混合溶液；

[0052]经过充分搅拌及烘干机烘干后，最终得到高分子生物膜。

Example Embodiment

[0053]实施例三：

[0054]一种复合医用生物高分子材料的制备方法，基于实施例一，不同的是在第三步；

[0055]经过充分搅拌及冷冻干燥干后，最终得到高分子生物海绵。

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Abstract

The invention discloses a composite medical biopolymer material which comprises the following raw materials: soluble chitin macromolecules, aminated hyaluronic acid or cationic hyaluronic acid and deionized water, and further comprises one or more of a cross-linking agent and a cosolvent, the preparation method of the composite medical biopolymer material comprises the following steps: placing all the raw materials in a stirring device according to a certain proportion to form a mixed solution; a mixed solution in the stirring device flows circularly, the spraying mechanism is driven by reverse thrust of the spraying mechanism to rotate, the scraper mechanism is pushed to reciprocate up and down in the stirring device in the process, and the to-be-processed product is dried or freeze-dried by a dryer to form a high polymer material product; the optimal modified composite high polymer material product is obtained by adjusting the structural design of a soluble chitin high polymer material, a cationic hyaluronic acid high polymer material and a cross-linking agent, the cross-linking reaction degree and the chemical reaction type control.

Description

technical field [0001] The invention belongs to the technical field of polymer materials, and in particular relates to a composite medical biopolymer material and a preparation method thereof. Background technique [0002] The excellent properties of polymer materials have been widely used in medicine, but there are cumbersome processes and harsh reaction conditions in the preparation process, and the control of improving the physical and chemical properties of polymer materials is not accurate enough. And the aspects such as preparation technology do not have very good advantage. Contents of the invention [0003] In order to solve the above-mentioned problems in the prior art, the purpose of the present invention is to provide a composite medical biopolymer material and a preparation method thereof. [0004] The technical scheme adopted in the present invention is: [0005] A composite medical biopolymer material, the raw materials used include: soluble chitin polymer,...

Claims

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Application Information

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IPC IPC(8): B01F27/90B01F25/54B01F25/20B01F35/12A61K47/36A61L15/28A61L15/42
CPCA61L15/28A61L15/425A61K47/36C08L5/08
Inventor 杜一雄丁勇陈秋扬
Owner 湖南益安生物科技有限公司
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