Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of Desloratadine and salts thereof in preparation of drugs for treating neurodegenerative diseases related to dyskinesia

A technique for motor dysfunction and desloratadine, applied in the field of application of desloratadine and its salts in the preparation of drugs for the treatment of neurodegenerative diseases related to motor dysfunction, capable of solving motor dysfunction and other problems to achieve the effect of improving motor dysfunction

Active Publication Date: 2021-11-23
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
View PDF2 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on its ability to improve the motor dysfunction of SOD1-G93A model mice, thus playing the role of anti-amyotrophic lateral sclerosis

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of Desloratadine and salts thereof in preparation of drugs for treating neurodegenerative diseases related to dyskinesia
  • Application of Desloratadine and salts thereof in preparation of drugs for treating neurodegenerative diseases related to dyskinesia
  • Application of Desloratadine and salts thereof in preparation of drugs for treating neurodegenerative diseases related to dyskinesia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0015] The present invention will be further described below in conjunction with specific embodiments, but these embodiments should not be construed as limiting the present invention.

[0016] Test implementation: Desloratadine improved the motor dysfunction state of SOD1-G93A model mice in the behavioral experiments of the Rotard rod test, gait monitoring test and hanging cage test, and effectively delayed the SOD1-G93A model. Rat onset time, prolong its life cycle.

[0017] The present invention is used in SOD1-G93A model mice to detect the effect of desloratadine on the improvement of the motor dysfunction state of mice. The state of motor dysfunction exhibited in the behavioral experiments of the gait monitoring experiment and the hanging cage experiment.

[0018] 1. Experimental principle

[0019] 1) Rotard Rod Experiment: SOD1-G93A model mice will have motor dysfunction when they are onset, so the motor coordination and balance function of the forelimb and hind limbs c...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a new application of Desloratadine (DLT) and pharmaceutically acceptable salts thereof in preparation of drugs for treating neurodegenerative diseases related to dyskinesia. A large number of experiments show that DLT and the pharmaceutically acceptable salts thereof can improve the dyskinesia state of SOD1-G93A model mice in behavioral experiments of a Rotard bar-rotating experiment, a gait monitoring experiment and a cage experiment, effectively delay the onset time of the SOD1-G93A model mice and prolong the life cycle of the SOD1-G93A model mice. DLT and the pharmaceutically acceptable salts thereof can be used for treating the neurodegenerative diseases related to dyskinesia including amyotrophic lateral sclerosis.

Description

technical field [0001] The invention relates to the field of drug therapy, in particular to the application of desloratadine and a pharmaceutical composition thereof in the preparation of medicines for the treatment of motor dysfunction-related neurodegenerative diseases, and more particularly, the invention relates to desloratadine Tadine and its pharmaceutically acceptable salts or pharmaceutical compositions thereof can improve the motor dysfunction of SOD1-G93A model mice, and are used in the preparation of medicines for treating neurodegenerative diseases such as amyotrophic lateral sclerosis. Background technique [0002] Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, also known as "ALS", which mainly affects the spinal cord, cerebral cortex and brainstem motor neurons. ALS usually occurs in middle-aged and elderly people or later. Patients will show progressive muscle atrophy and weakness after onset, and eventually die from respiratory fail...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4545A61P25/00A61P21/00A61P25/14
CPCA61K31/4545A61P25/00A61P21/00A61P25/14A61K31/4465A61P25/28
Inventor 沈旭王佳颖黄玉洁卢健何安旭
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com