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Optical computer interface system for whole-brain multi-mode neural activity detection

A neural activity, brain-computer interface technology, applied in electrodes, electrotherapy, head electrodes, etc., can solve problems such as difficult detection, low detection resolution, and inability to observe neural activity in subcortical nuclei.

Active Publication Date: 2021-11-30
TSINGHUA UNIV
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  • Abstract
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  • Application Information

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Problems solved by technology

However, limited by the small detection range span, low detection resolution and small number of detection neurons of the existing neural activity detection technology, it is very difficult to detect mesoscopic large-scale whole brain cortex-subcortical nuclei synchronously with high resolution. , hindering our further understanding of the functional connection mechanism of neural networks
[0003]In the current research, there are two main ways to record large-scale neural information of the whole brain: Wide-field imaging technology records the neural activity of the whole brain cortex, which can record High-spatial-resolution neural activity information of single neurons in the whole brain cortex, but the neural activity of subcortical nuclei cannot be observed; high-throughput neural microelectrode array technology can be implanted in any brain nuclei to obtain high-spatial-temporal resolution High-speed electrophysiological signals, yet extremely limited in recording range
Optical and electrical recording methods have their own advantages and disadvantages: a single neural information recording leads us to only read the information of brain surface activity or the neural activity of individual nuclei in the deep
[0004]In summary, the existing technology cannot obtain more global neural activity information, which prevents us from fully understanding the neural function mechanism of the brain

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Embodiment Construction

[0042] Embodiments of the present application are described in detail below, examples of which are shown in the drawings, wherein the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. The embodiments described below by referring to the figures are exemplary, and are intended to explain the present application, and should not be construed as limiting the present application.

[0043] The following describes the optical-computer interface system for whole-brain multi-modal neural activity detection of the embodiment of the present application with reference to the accompanying drawings. The optical-computer interface system includes a wide-field optical imaging system, an electrophysiological recording control system, and an animal facial expression shooting system. three parts, figure 1 It is a schematic structural diagram of an optical-computer interface system for whole-brain multi-modal neural ...

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Abstract

The invention discloses an optical computer interface system for whole-brain multi-mode neural activity detection, and relates to the technical field of multi-mode neural activity optical computer interfaces. The system comprises a wide-field optical imaging system, an electrophysiological record regulation system and an animal facial expression shooting system. The neural activity information, the electrophysiological activity information and facial expression change information can be synchronously acquired by the wide-field optical imaging system, the electrophysiological record regulation system and the animal facial expression shooting system, and constitute multi-modal neural activity information. The acquired multi-modal neural activity information can help technicians in the field to master more global information of the brain, can be used for researching a functional mechanism of interaction between the cortical layer and the subcortical nuclei related to the whole brain, and provides an idea for exploring a new biological mechanism.

Description

technical field [0001] The present application relates to the technical field of multimodal neural activity optical-computer-computer interface, in particular to an optical-computer-computer interface system for whole-brain multimodal neural activity detection. Background technique [0002] The neural information interaction mode and neuron functional connection network of the whole brain cortex and subcortical nuclei are the important basis for us to analyze the whole brain functional connection map. The recording and regulation of large-scale multimodal neural activity information in the whole brain is an important way for us to understand the brain. However, limited by the small detection range span, low detection resolution and small number of detection neurons of the existing neural activity detection technology, it is very difficult to detect mesoscopic large-scale whole brain cortex-subcortical nuclei synchronously with high resolution. , hindering our further unders...

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Application Information

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IPC IPC(8): A61B5/377A61B5/00A61B5/395A61N1/04A61N1/05A61N1/36
CPCA61B5/377A61B5/0059A61N1/3605A61B5/395A61N1/0531A61N1/0476
Inventor 戴琼海吴嘉敏肖桂花谢浩张元龙蔡烨怡
Owner TSINGHUA UNIV
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