Optical computer interface system for whole-brain multi-mode neural activity detection

Abstract

The invention discloses an optical computer interface system for whole-brain multi-mode neural activity detection, and relates to the technical field of multi-mode neural activity optical computer interfaces. The system comprises a wide-field optical imaging system, an electrophysiological record regulation system and an animal facial expression shooting system. The neural activity information, the electrophysiological activity information and facial expression change information can be synchronously acquired by the wide-field optical imaging system, the electrophysiological record regulation system and the animal facial expression shooting system, and constitute multi-modal neural activity information. The acquired multi-modal neural activity information can help technicians in the field to master more global information of the brain, can be used for researching a functional mechanism of interaction between the cortical layer and the subcortical nuclei related to the whole brain, and provides an idea for exploring a new biological mechanism.

Description

technical field [0001] The present application relates to the technical field of multimodal neural activity optical-computer-computer interface, in particular to an optical-computer-computer interface system for whole-brain multimodal neural activity detection. Background technique [0002] The neural information interaction mode and neuron functional connection network of the whole brain cortex and subcortical nuclei are the important basis for us to analyze the whole brain functional connection map. The recording and regulation of large-scale multimodal neural activity information in the whole brain is an important way for us to understand the brain. However, limited by the small detection range span, low detection resolution and small number of detection neurons of the existing neural activity detection technology, it is very difficult to detect mesoscopic large-scale whole brain cortex-subcortical nuclei synchronously with high resolution. , hindering our further unders...

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Problems solved by technology

However, limited by the small detection range span, low detection resolution and small number of detection neurons of the existing neural activity detection technology, it is very difficult to detect mesoscopic large-scale whole brain cortex-subcortical nuclei synchronously with high resolution. , hindering our further understanding of the functional connection mechanism of neural networks

[0003]In the current research, there are two main ways to record large-scale neural information of the whole brain: Wide-field imaging technology records the neural activity of the whole brain cortex, which can record High-spatial-resolution neural activity information of single neurons in the whole brain cortex,

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