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A pharmaceutical composition for rapid healing of osteoporotic fractures

A technology for osteoporosis and composition, applied in the field of western medicine, can solve problems such as slow osteogenesis and insufficient bone fusion

Active Publication Date: 2022-07-29
AFFILIATED HOSPITAL OF JINING MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0010] In view of the fact that when osteoporotic fractures are treated with simple surgical fixation and implants, there are often clinical problems such as insufficient bone fusion and slow osteogenesis, the purpose of the present invention is to provide a rapid A medicinal composition for healing to solve the above technical problems

Method used

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  • A pharmaceutical composition for rapid healing of osteoporotic fractures
  • A pharmaceutical composition for rapid healing of osteoporotic fractures

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Embodiment Construction

[0017] The present invention will be further described in detail below according to specific test examples, and the advantages and characteristics of the present invention will become more clear with the description. It should be understood by those skilled in the art that the details and forms of the technical solutions can be modified or replaced without departing from the spirit of the present invention, but these modifications or replacements all fall within the protection scope of the present invention.

[0018] Forty-eight SD male rats, weighing 260-300 g, were divided into blank control group, model control group, trimebutine group, alendronate sodium group, trimebutine-alendronate sodium group according to the random number table method Low-dose group and trimebutine-alendronate sodium high-dose group, 8 rats in each group.

[0019] Except for the blank control group, rats in other groups were given 70 mg / kg of retinoic acid by gavage, once a day, and osteoporosis was ...

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Abstract

The invention belongs to the technical field of western medicine, and discloses a pharmaceutical composition for the rapid healing of osteoporotic fractures. The pharmaceutical composition is an oral preparation, and the oral preparation is composed of trimebutine maleate, bisphosphonate and pharmaceutically acceptable excipients. In the invention, trimebutine maleate improves the biological activity of bisphosphonates in promoting bone formation in vivo, reduces the functional activity of osteoclasts, and inhibits bone resorption, thereby synergistically improving bone density and promoting osteoporosis. Rapid healing of fractures.

Description

technical field [0001] The invention belongs to the technical field of western medicine, and relates to a medicament for bone wound healing, in particular to a medicament composition for rapid healing of osteoporotic fractures. Background technique [0002] Osteoporosis is a systemic bone disease that is prone to fracture due to the decrease of bone density and bone quality due to various reasons, the destruction of bone microstructure, and the increase of bone fragility [CHEUNG WH, MICLAU T, CHOW SKH, et al. Fracture] healing in osteoporotic bone. Injury. 2016;47(Suppl 2):S21-S26.]. According to physiological and anatomical standards, bone tissue is composed of cells, fibers and matrix, and belongs to connective tissue with higher density and greater hardness. Its elastic properties allow bone tissue to deform to a certain extent under load. The biomechanical properties of bone tissue depend on bone density and trabecular distribution and are also affected by osteoporosis....

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/24A61K31/663A61K31/675A61K9/20A61P19/08A61P19/10
CPCA61K31/24A61K31/675A61K31/663A61K9/0053A61K9/2059A61K9/2018A61K9/2054A61K9/2013A61K9/2009A61P19/08A61P19/10A61K2300/00
Inventor 孙鹏韩亮邢春叶
Owner AFFILIATED HOSPITAL OF JINING MEDICAL UNIV
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