Traditional Chinese medicine composition for central nervous injury complicated with secondary pulmonary infection and application of traditional Chinese medicine composition

A technology of the central nervous system and composition, which is applied in the direction of drug combination, nervous system diseases, and pharmaceutical formulations.

Active Publication Date: 2021-12-07
TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, at present, the research on traditional Chinese medicine compound for severe complicated secondary pulmonary infection is not in-depth. CN110420234A discloses the use of Babaodan in the preparation of medicines for preventing or treating secondary bacterial infection of influenza. It is found that Babaodan can significantly improve the The inflammatory response in the lungs of infected mice inhibited the expression and release of inflammatory factors such as IL-6, TNF-α, KC, and MIP2; using a macrophage Toll-like receptor (TLRs) activation model, it was found that Babaodan can significantly inhibit the immune system Inflammatory factor secretion caused by excessive cell activation

Method used

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  • Traditional Chinese medicine composition for central nervous injury complicated with secondary pulmonary infection and application of traditional Chinese medicine composition
  • Traditional Chinese medicine composition for central nervous injury complicated with secondary pulmonary infection and application of traditional Chinese medicine composition
  • Traditional Chinese medicine composition for central nervous injury complicated with secondary pulmonary infection and application of traditional Chinese medicine composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Take 162g each of ginseng, dried ginger, licorice, and Atractylodes macrocephala, and the four herbs are qualified through identification. Cut ginseng into thin slices, combine it with other four herbs, soak it in 10 times the amount of 75% ethanol for 30 minutes, put it in a round bottom flask, start the first decoction, after boiling, turn down the heat and decoct for 1.5 hours, filter After that, decoct the dregs for the second time. Add 8 times the amount of 75% ethanol to decoct for 1 hour, filter and combine the two filtrates, evaporate the solvent in a rotary evaporator at 55°C, and concentrate to obtain an extract with a concentration of 2g / ml.

Embodiment 2

[0031] Take 160g each of ginseng, dried ginger, licorice, and Atractylodes macrocephala, and the four herbs have been identified as qualified. Cut ginseng into thin slices, combine it with other four herbs, soak it in 12 times the amount of 75% ethanol for 30 minutes, put it in a round bottom flask, start the first decoction, reflux decoction for 2 hours, filter, and remove the medicinal residues Cook for the second time. Add 8 times the amount of 75% ethanol to decoct for 1 hour, filter and combine the two filtrates, evaporate the solvent in a rotary evaporator at 55°C, concentrate to an extract with a concentration of 2g / ml, dry and crush through an 80-mesh sieve to prepare Powder.

Embodiment 3

[0033] Take 20g of ginseng, 20g of dried ginger, 20g of licorice, and 35g of Atractylodes macrocephala, and the four herbs are qualified through identification. Cut ginseng into thin slices, combine with other four herbs, soak in 15 times the amount of water for 30 minutes, reflux and decoct for 2 hours, filter, and decoct the medicinal residues for the second time. Add 10 times the amount of water and decoct for 1.5 hours, filter and combine the two filtrates, concentrate to obtain an extract with a concentration of 2g / ml, dry, pulverize and pass through an 80-mesh sieve, add starch and magnesium stearate to make granules.

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Abstract

The invention discloses a traditional Chinese medicine composition for central nervous injury complicated with secondary pulmonary infection. The traditional Chinese medicine composition is prepared from dried ginger, ginseng, bighead atractylodes rhizome and the like. The traditional Chinese medicine composition can effectively prevent or treat central nervous injury combined with secondary pulmonary infection, especially severe central nervous injury, reduce the fatality rate and sequelae, and solve the problem of drug resistance caused by antibiotic abuse.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine composition for central nervous system injury combined with secondary pulmonary infection and its application. Background technique [0002] Studies have found that severe central nervous system injuries such as stroke (cerebral hemorrhage and cerebral ischemia), traumatic brain injury TBI, spinal cord injury and other high incidence of lung infection and urinary tract infection, and infection can not only slow down the recovery of neurological function of patients, prolong hospitalization Over time, it will also lead to an increase in the mortality rate and seriously affect the prognosis. Among them, traumatic brain injury is the main factor of increasing mortality worldwide. More than 50 million people in the world suffer from traumatic brain injury every year, and the incidence rate has continued to increase in the past 10 ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61P25/00A61P7/04A61P9/10A61P25/28A61P7/10A61P9/02A61P1/00A61P11/00
CPCA61K36/9068A61K36/258A61K36/284A61K36/484A61P25/00A61P7/04A61P9/10A61P25/28A61P7/10A61P9/02A61P1/00A61P11/00A61K2236/331A61K2236/33A61K2236/333A61K2300/00
Inventor 庄朋伟杨珍张蜜霞郭虹张艳军
Owner TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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