Arbitrarily shaped, deep sub-wavelength acoustic manipulation for microparticle and cell patterning

A patterned, patterned layer technology, applied in the direction of material selection for piezoelectric devices or electrostrictive devices, laboratory containers, chemical instruments and methods, etc., can solve the problem of damage to manipulated samples, SAW large areas Issues such as patterning difficulties, buffer incompatibility, and electrical interference

Pending Publication Date: 2021-12-21
RGT UNIV OF CALIFORNIA
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  • Description
  • Claims
  • Application Information

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Problems solved by technology

Other methods based on electrokinetics, such as dielectrophoresis and electroosmosis, are simple to implement but are challenged by buffer incompatibility and electrical interference, which can damage manipulated samples
3D printing (Chia HN et al., Journal of biological engineering, 9(1), 4; Panwar A et al., Molecules, 21(6), 685) provides another means to form complex patterned contours, but has not yet Enables precise control over what it prints, thus limiting resolution
However, due to the nature of standing waves, SAWs face similar problems with limited patterned profiles that are often symmetrical
Furthermore, the rapid decay of SAW due to energy transfer to the fluid makes large-area patterning difficult; typical SAW devices cannot operate in areas larger than 1 mm × 1 mm (Collins DJ et al., Nature communications, 6, 8686)

Method used

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  • Arbitrarily shaped, deep sub-wavelength acoustic manipulation for microparticle and cell patterning
  • Arbitrarily shaped, deep sub-wavelength acoustic manipulation for microparticle and cell patterning
  • Arbitrarily shaped, deep sub-wavelength acoustic manipulation for microparticle and cell patterning

Examples

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Embodiment 1

[0053] Example 1: Deep Subwavelength Acoustic Manipulation of Arbitrary Shapes for Microparticle and Cell Patterning

[0054] Methods to achieve complex patterning of microscopic objects are crucial for many biomedical applications. In recent years, acoustic manipulation has emerged as a promising method to pattern biological samples due to its excellent biocompatibility. However, current acoustic techniques encounter major technical hurdles in forming complex patterns and are thus limited to producing simple and periodic object assemblies. In contrast to other physical methods, arbitrary shaped patterns cannot be achieved using current techniques based on surface acoustic waves (SAW) or bulk acoustic waves (BAW). This barrier arises from their standing wave nature (which is the intrinsic mechanism) and the coupled fluid-structure vibrations within them.

[0055] This study demonstrates a new principle of acoustic manipulation that overcomes the technical hurdles of the pr...

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Abstract

The present invention relates to a near-field acoustic platform capable of synthesizing high resolution, arbitrarily shaped energy potential wells. A thin and viscoelastic membrane is utilized to modulate acoustic wavefront on a deep, sub wavelength scale by suppressing the structural vibration selectively on the platform. This new acoustic wavefront modulation mechanism is powerful for manufacturing complex biologic products.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to U.S. Provisional Patent Application No. 62 / 837,768, filed April 24, 2019, the contents of which are hereby incorporated by reference in their entirety. [0003] Statement Regarding Federally Sponsored Research or Development [0004] This invention was made with government support under Grant No. 1711507 from the National Science Foundation. The Government has certain rights in this invention. Background technique [0005] Methods for manipulating biological objects on the micrometer to centimeter scale are fundamental to many biomedical applications, including the study of cell-cell interactions (Nilsson J et al., Analytica chimica acta, 649(2), 141-157; Sun J et al., Biomaterials, 35(10), 3273-3280), single cell analysis (Wood DK et al., Proceedings of the National Academy of Sciences, 107(22), 10008-10013; Collins DJ et al., Lab ona Chip, 15 (17), 3439-3459), drug development (Ka...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): H01L41/047H01L41/18H03H9/02
CPCB01L3/50273B01L2400/0439B01L2300/123B01L3/502761B01L2300/161B01L3/502B01L2200/0647B01L2200/147B01L2200/12B01L2300/1894
Inventor 邱培钰童冠文胡恩明
Owner RGT UNIV OF CALIFORNIA
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