SLE antigen itope polypeptide and effect thereof in SLE diagnosis

Abstract

The invention discloses an SLE antigen epitope polypeptide and an effect thereof in SLE diagnosis. The antigen epitope polypeptide can provide a new target for SLE diagnosis, is used for well distinguishing SLE patients from healthy people and other patients with autoimmune diseases, is convenient for providing new diagnosis strategies and reagents, and makes up the vacancy of the existing SLE diagnosis technology. The antigen epitope polypeptide provided by the invention is excellent in diagnosis efficiency, so that the sensitivity and the specificity of diagnosis can be ensured while the above novel diagnosis strategy, technology and reagent is provided. Multiple antigen epitope polypeptides or combination of the multiple antigen epitope polypeptides and an existing autoantibody can improve the sensitivity and the specificity of the diagnosis so as to obtain a more effective diagnosis result. In addition to the above beneficial effects, the antigen epitope polypeptide is also beneficial to providing a research basis for elaboration of an SLE generation mechanism, so that the generation mechanism is deeply researched on the basis of the antigen epitope polypeptide, and development on the aspects of SLE diagnosis and treatment is promoted.

Description

technical field [0001] The invention relates to the technical field of immunological diagnosis, and more specifically relates to a SLE antigenic epitope polypeptide and its role in SLE diagnosis. Background technique [0002] Systemic lupus erythematosus (SLE) is a common and complex autoimmune disease, also known as the "prototype" of autoimmune diseases. Its clinical manifestations are complex and diverse, and often involve multiple systems of the body. Including kidney, skin, joints, nervous system, serosa, etc., resulting in damage to related tissues and organs. In severe cases, it can also cause symptoms such as multiple organ failure and central nervous system damage, leading to death of the patient. Therefore, early diagnosis is very important to timely reduce or avoid the involvement of important organs, improve the prognosis of patients, and increase the survival rate of patients. [0003] However, since the pathogenesis of SLE has not yet been fully elucidated, t...

AI Technical Summary

Problems solved by technology

For example, some autoimmune diseases other than SLE will also have positive results. It is difficult to diagnose SLE from other autoimmune diseases, and for each antibody, the detection efficiency is also flawed in one or more aspects. Increasingly Difficult to Meet Demand for SLE Diagnosis

For example, anti-dsDNA antibody and anti-Sm antibody have high specificity for the diagnosis of SLE, and can well distinguish SLE from other autoimmune diseases, but they also have the defect of low positive rate

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