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Application of besifloxacin in preparation of medicine for treating tuberculosis

A technology of besifloxacin and tuberculosis, applied in the field of medicine to achieve the effect of increasing the possibility

Pending Publication Date: 2021-12-31
BEIJING CHEST HOSPITAL CAPITAL MEDICAL UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

To date, there are no reports of besifloxacin's antituberculosis activity

Method used

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  • Application of besifloxacin in preparation of medicine for treating tuberculosis
  • Application of besifloxacin in preparation of medicine for treating tuberculosis
  • Application of besifloxacin in preparation of medicine for treating tuberculosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0032] 1. Drug sensitivity test

[0033] The activity of besifloxacin against Mycobacterium tuberculosis (MTB) standard strain H37Rv and clinically sensitive isolates, drug-resistant strains and non-tuberculous mycobacteria (NTM) in vitro was determined by microdilution method in a 96-well plate, and it was also used against tuberculosis commonly used Drugs isoniazid, rifampicin, levofloxacin and moxifloxacin were compared.

[0034] 1. Materials

[0035] 1.1 Tested bacteria: Mycobacterium tuberculosis standard strain H37Rv (ATCC: 27294), 1 clinically sensitive strain (S), 6 strains of drug-resistant bacteria, 5 strains of non-tuberculous mycobacteria (Mycobacterium kansassi, Mycobacterium intracellulare, Mycobacterium fortuitum, Mycobacterium avium, Mycobacterium abscessus);

[0036] 1.2 Antibacterial drugs: Besifloxacin (BFX), levofloxacin (LFX), moxifloxacin (MFX), isoniazid (INH), rifampin (RIF);

[0037] 1.3 Medium: 7H9 liquid medium, Mueller-Hinton II-Bouillon medium. ...

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PUM

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Abstract

The invention discloses application of besifloxacin or a pharmaceutical composition containing besifloxacin in preparation of a medicine for preventing and / or treating tuberculosis, and relates to the technical field of medicines. Experiments prove that the besifloxacin has a good inhibition effect on mycobacteria and nontuberculous mycobacteria in vitro, can be used for preparing the medicine for resisting the mycobacteria tuberculosis and the medicine for preventing and / or treating tuberculosis, and provides a new medicine choice for treating tuberculosis.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of besifloxacin or a pharmaceutical composition containing besifloxacin in the preparation of medicines for preventing and / or treating tuberculosis. Background technique [0002] Tuberculosis (TB) is a chronic respiratory infectious disease caused by Mycobacterium tuberculosis (MTB). It is one of the top ten causes of death in the world and the main cause of death caused by a single infectious agent. The number of deaths from TB in 2019 was 1.2 million. MTB has special physiological characteristics, including slow growth, high gene mutation rate in the natural state, and easy formation of persistent strains after medication, etc., resulting in a long cycle of TB treatment and poor patient compliance, so the detection of drug-resistant MTB rate keeps rising. The latest WHO global tuberculosis report in 2020 shows that there are an estimated 10 million new cases ...

Claims

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Application Information

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IPC IPC(8): A61K31/55A61P31/06
CPCA61K31/55A61P31/06Y02A50/30
Inventor 杨瑞芳蒙建州李传友刘毅刘忆霜逄宇王潇关艳
Owner BEIJING CHEST HOSPITAL CAPITAL MEDICAL UNIV
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