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Preparation method of enzyme-free glucose sensor of bimetal organic framework

The technology of a glucose sensor and an organic framework is applied in the field of preparation of an enzyme-free glucose sensor, which can solve problems such as defects in finished products of nanoparticles, and achieve the effects of good morphology and performance, saving time and cost, and improving the sensitivity of electrocatalysis.

Pending Publication Date: 2022-01-07
江苏集萃医工交叉技术研究所有限公司
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  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

[0004] Technical problem to be solved: This application mainly proposes a method for preparing a bimetallic organic framework enzyme-free glucose sensor, which solves the current conventional hydrothermal or solvothermal methods for preparing nanoparticles and the defects of finished products in the prior art. question

Method used

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  • Preparation method of enzyme-free glucose sensor of bimetal organic framework
  • Preparation method of enzyme-free glucose sensor of bimetal organic framework
  • Preparation method of enzyme-free glucose sensor of bimetal organic framework

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preparation example Construction

[0029] A method for preparing an enzyme-free glucose sensor with a double metal organic framework, specifically comprising the following steps:

[0030] First step, sprinkle Al on the suede polishing cloth 2 o 3 Polishing powder, add deionized water and mix thoroughly to get a polishing solution, hold the glassy carbon electrode vertically, and use the "8" path to polish the glassy carbon electrode evenly, ultrasonically clean the electrode in deionized water and absolute ethanol, and again Grinding and cleaning once, the "8" path can be evenly polished from all directions, avoiding obvious scratches on the glassy carbon electrode caused by grinding up and down or left and right, and uniform vertical force can avoid grinding the glassy carbon electrode into a bevel.

[0031] In the second step, the glassy carbon electrode polished and cleaned in the first step is placed in H 2 SO 4 The solution was activated by cyclic voltammetry, and the activated glassy carbon electrode r...

Embodiment 1

[0050] A method for preparing an enzyme-free glucose sensor quantum dot airgel paper-based sensor of a double metal organic framework, specifically comprising the following steps:

[0051] In the first step, sprinkle 0.3μm Al on the suede polishing cloth 2 o 3 Polishing powder, add deionized water and mix thoroughly to obtain a polishing liquid, hold the glassy carbon electrode vertically, and use the "8" path of the polishing liquid to evenly polish the glassy carbon electrode, and then ultrasonicate the electrode in deionized water and absolute ethanol Wash at 80kHz for 8s, sprinkle 0.05μm Al on the suede polishing cloth for the second time 2 o 3 Polish and clean the glassy carbon electrode again with polishing powder, and ensure that the glassy carbon electrode does not touch the beaker wall during the process.

[0052] In the second step, the glassy carbon electrode polished and cleaned in the first step is placed in 0.5M H 2 SO 4 The solution was activated by cyclic ...

Embodiment 2

[0059] A method for preparing an enzyme-free glucose sensor quantum dot airgel paper-based sensor of a double metal organic framework, specifically comprising the following steps:

[0060] In the first step, sprinkle 0.3μm Al on the suede polishing cloth 2 o 3 Polishing powder, add deionized water and mix thoroughly to obtain a polishing liquid, hold the glassy carbon electrode vertically, and use the "8" path of the polishing liquid to evenly polish the glassy carbon electrode, and then ultrasonicate the electrode in deionized water and absolute ethanol Wash at 80kHz for 8s, sprinkle 0.05μm Al on the suede polishing cloth for the second time 2 o 3 The polishing powder is used to polish the glassy carbon electrode again and clean it again, ensuring that the glassy carbon electrode does not touch the beaker wall during the process.

[0061] In the second step, the glassy carbon electrode polished and cleaned in the first step is placed in 0.5M H 2 SO 4 The solution was act...

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Abstract

The invention discloses a preparation method of an enzyme-free glucose sensor of a bimetal organic framework. By adjusting the proportion of Co and Zn elements in ZIF67 / ZIF8, the excellent performance of a hybrid transition metal-based compound in the field of enzyme-free glucose sensing is shown; and compared with the electro-catalysis performance of a monometal organic framework, The electro-catalysis performance of the bimetal organic framework on glucose is improved. Besides, in order to verify the practical application capability of the ZIF67 / ZIF8, a human serum sample is analyzed in real time, and good anti-interference capability and recovery rate of the sensor are proved. The method has the advantages of being low in cost, easy to produce, high in environmental tolerance and the like, and a universal non-noble metal biosensing material is provided for non-enzymatic glucose detection.

Description

technical field [0001] The invention belongs to the technical field of micro-nano medical devices, and in particular relates to a preparation method of an enzyme-free glucose sensor with a bimetallic organic framework. Background technique [0002] Sensitive and rapid glucose detection is of great significance to food industry, biotechnology, medicine and other fields, especially for early monitoring and self-detection of diabetes. Diabetes is estimated to account for 11.3% of deaths worldwide, accounting for 4.2 million deaths among adults aged 20-79. [0003] The current glucose detection sensors are mainly divided into enzyme-containing sensors and enzyme-free sensors. Since enzymes are easily affected by temperature, pH and environmental conditions, the application of stable non-enzyme materials in glucose sensors has been increasingly promoted. So far, researchers have made many efforts to develop enzyme-free electroactive materials, among which electrode materials b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/327G01N27/30
CPCG01N27/3278G01N27/308
Inventor 杨俊宇屠小明胡建军
Owner 江苏集萃医工交叉技术研究所有限公司