Application of canagliflozin and analogs thereof in preparation of medicine for preventing and treating male reproductive dysfunction

A canagliflozin pharmaceutical and male reproductive technology, applied in the field of biomedicine to achieve high application value and social benefits

Active Publication Date: 2022-01-11
PEKING UNIV THIRD HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the effect of this class of drugs on reproductive function has not yet been reported

Method used

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  • Application of canagliflozin and analogs thereof in preparation of medicine for preventing and treating male reproductive dysfunction
  • Application of canagliflozin and analogs thereof in preparation of medicine for preventing and treating male reproductive dysfunction
  • Application of canagliflozin and analogs thereof in preparation of medicine for preventing and treating male reproductive dysfunction

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Experimental program
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Effect test

Embodiment

[0030] 1. Experimental method:

[0031] Typical features of leptin receptor-deficient model mice (db / db) include metabolic disturbances such as hyperleptinemia, obesity, hyperglycemia, hyperinsulinemia, decreased prolactin in serum and increased prolactin in pituitary, and typical infertility [Science. 1966 Sep 2;153(3740):1127-1128]. Humans with mutations in leptin or its receptors are also obese and infertile [Endocrine reviews. 2006; 27: 710–718]. The classic animal model of type 2 diabetes, db / db mice, exhibits pathological phenotypes very similar to those of diabetic males in male reproductive system damage, including abnormal spermatogenic function and sexual dysfunction, and is the most commonly used to study male infertility and sexual dysfunction. One of the models [Biochemical and BiophysicalResearch Communications, 2017; 485: 686-692; Diabetologia 2020 09;63(9)]. Therefore, we chose this typical type 2 diabetic mouse as a model of male testicular tissue injury for...

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PUM

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Abstract

The invention belongs to the technical field of biomedicines. The invention particularly relates to application of canagliflozin and analogs thereof in preparation of a medicine for preventing and treating male reproductive dysfunction. Research results show that spermatogenic cells at all levels in seminiferous tubules of db / db mice treated by the canagliflozin reappear and are regularly arranged, meanwhile, a small amount of sperms exist in the tubules, and the canagliflozin treatment can be used for significantly improving abnormal sperm quality, abnormal sperm number and abnormal sperm movement of the db / db mice. The canagliflozin and analogs thereof are used for preventing or treating the male reproductive dysfunction for the first time, an ideal treatment effect is achieved, a new prevention and treatment choice is provided for clinical application and treatment of male sterility, especially male sterility caused by diabetes or hyperglycemia, and extremely high application values and social benefits are achieved.

Description

technical field [0001] The invention belongs to the technical field of biomedicine. It specifically relates to the use of canagliflozin and its analogs in the preparation of drugs for preventing and treating male reproductive dysfunction. Background technique [0002] In recent years, with the aggravation of environmental pollution and the delay of childbearing age, the incidence of male infertility has been increasing year by year. The most direct consequence of the increase in the incidence of infertility is the reduction of the fertility rate, which will further accelerate the process of my country's entry into an aging society. Sustainable development poses serious challenges. The occurrence of infertility is related to many factors, the individual differences are large, and the pathogenic factors are complex, which brings difficulties to the research and treatment of the disease. The incidence of male infertility is related to many factors such as environment, heredit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/381A61P15/08
CPCA61K31/381A61P15/08
Inventor 张哲金滋润魏蕊杨宇卓姜辉洪天配杨进姜雅菲
Owner PEKING UNIV THIRD HOSPITAL
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