Target molecule positioning method and positioning system for sonodynamic therapy

A positioning method and positioning system technology, applied in the precise positioning technology of tumor blood vessel-specific molecules, in the field of tumors, can solve the problem that the treatment effect needs to be further improved, and achieve the effect of increasing the controllable range, reducing toxic side effects, and reducing the impact

Pending Publication Date: 2022-01-14
上海释康企业管理咨询合伙企业(有限合伙)
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

At present, the methods of clinical treatment of tumors are mainly surgery, radiotherapy, chemotherapy, immunotherapy, traditional Chinese medicine and their combinations. However, the existing clinical treatment methods have considerable limitations, and the therapeutic effect needs to be further improved.

Method used

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  • Target molecule positioning method and positioning system for sonodynamic therapy
  • Target molecule positioning method and positioning system for sonodynamic therapy
  • Target molecule positioning method and positioning system for sonodynamic therapy

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Experimental program
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Embodiment 1

[0039] The present invention provides a target molecule localization system 1 for sonodynamic therapy, see figure 1 , including a data acquisition system 11 and a data processing system 12; the data acquisition system 11 includes a phased array probe for transmitting signals and receiving reflected signals; the data processing system 12 is used for processing the phased array probe received signal and generate image information; the target molecule localization system 1 locates the target molecule in time and space by capturing the targeted quantum dot sound sensitizer.

[0040] Such as Figure 2-Figure 8 As shown, the phased array probe includes a base array, and the data processing system includes a PCB board and a controller; the base array includes a plurality of array elements, the back side of the base array is welded with pins, and the base array passes through The pins are installed on the electrode lead-out layer, the pins of the electrode lead-out layer correspond to ...

Embodiment 2

[0080] This embodiment provides a target molecule localization method for sonodynamic therapy, using a targeted quantum dot sound sensitizer to specifically mark the target molecule, combined with the precise positioning of ultrasonic molecular imaging in space, through ultrasonic phased array The technology precisely acts on the labeled target molecules with acoustic energy, and realizes the double precise positioning of the target molecules in terms of time and space. Wherein, the ultrasonic molecular imaging adopts the positioning system described in Embodiment 1.

[0081] The method for spatially positioning target molecules of the present invention can be used for precise treatment of tumor blood vessels. Angiogenesis-related factors mainly include vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), transforming growth factor-β (Transforming growth factor-β; TGF-β), fibroblast growth factor Factor (Fibroblast growth factor; FGF), tumor necrosis fact...

Embodiment 3

[0097] The quantum dot sonosensitizer complex prepared in Example 2 was used to study the targeted sonodynamic therapy of 7 kinds of tumors.

[0098] 7 types of tumor cells: MDA-MB-231 (human breast cancer cells), SGC7901 (human gastric cancer cells), SKOV3 (human ovarian cancer cells), SGC996 (human gallbladder cancer cells), HCC827 (human non-small cell lung cancer cells) , PC3 (human prostate cancer cells), 8305C (human thyroid cancer cells).

[0099] Quantum dots are enriched in the tumor cytoplasm by means of co-incubation, and a large amount of singlet oxygen generated by quantum dots under ultrasonic irradiation can effectively kill tumor cells. Wherein, the dosage of the quantum dot-sound sensitizer complex is 30-100 μg / mL, specifically 50 μg / mL, and the irradiation time is 9 minutes.

[0100] The results show that a large amount of singlet oxygen generated by targeted quantum dots under ultrasonic irradiation promotes the oxidative stress of tumor cells, which in tur...

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Abstract

The invention discloses a target molecule positioning method for sonodynamic therapy. The target molecule positioning method comprises the following steps: performing specific identification on a target molecule by adopting a targeted quantum dot sonosensitizer, and accurately acting acoustic energy on the identified target molecule through an ultrasonic phased array technology in combination with accurate positioning of ultrasonic molecular imaging in a space, thereby achieving dual precise positioning of the target molecule in time and space. The invention also discloses a target molecule localization system for sonodynamic therapy. According to the invention, precise positioning of ultrasonic molecular imaging in time and space and dual effective precise positioning of the targeted quantum dot sonosensitizer in targeted therapy are combined to perform dual effective precise positioning on focus target molecules, and acoustic energy is quantitatively and accurately acted on the identified target molecule through an ultrasonic phased array technology, so that precise therapy is realized.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to the precise positioning technology of specific molecules of tumors and tumor blood vessels in sonodynamic therapy. Background technique [0002] Malignant tumors seriously threaten human health, and targeted vascular therapy is an effective strategy for tumor treatment. At present, the methods of clinical treatment of tumors mainly include surgery, radiotherapy, chemotherapy, immunotherapy, traditional Chinese medicine and their combinations. However, the existing clinical treatment methods have considerable limitations, and the therapeutic effect needs to be further improved. Therefore, there is an urgent need for new and more effective methods to supplement. [0003] Sonodynamic therapy is a method of treating tumors by active oxygen free radicals generated by sound sensitizers (chemical) under the action of low-intensity ultrasound (physical). Under the action of ultrasound...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61N7/00A61B8/08
CPCA61N7/00A61B8/0833A61B8/0891
Inventor 郝良适郝长宁
Owner 上海释康企业管理咨询合伙企业(有限合伙)
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