Target molecule positioning method and positioning system for sonodynamic therapy
A positioning method and positioning system technology, applied in the precise positioning technology of tumor blood vessel-specific molecules, in the field of tumors, can solve the problem that the treatment effect needs to be further improved, and achieve the effect of increasing the controllable range, reducing toxic side effects, and reducing the impact
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Embodiment 1
[0039] The present invention provides a target molecule localization system 1 for sonodynamic therapy, see figure 1 , including a data acquisition system 11 and a data processing system 12; the data acquisition system 11 includes a phased array probe for transmitting signals and receiving reflected signals; the data processing system 12 is used for processing the phased array probe received signal and generate image information; the target molecule localization system 1 locates the target molecule in time and space by capturing the targeted quantum dot sound sensitizer.
[0040] Such as Figure 2-Figure 8 As shown, the phased array probe includes a base array, and the data processing system includes a PCB board and a controller; the base array includes a plurality of array elements, the back side of the base array is welded with pins, and the base array passes through The pins are installed on the electrode lead-out layer, the pins of the electrode lead-out layer correspond to ...
Embodiment 2
[0080] This embodiment provides a target molecule localization method for sonodynamic therapy, using a targeted quantum dot sound sensitizer to specifically mark the target molecule, combined with the precise positioning of ultrasonic molecular imaging in space, through ultrasonic phased array The technology precisely acts on the labeled target molecules with acoustic energy, and realizes the double precise positioning of the target molecules in terms of time and space. Wherein, the ultrasonic molecular imaging adopts the positioning system described in Embodiment 1.
[0081] The method for spatially positioning target molecules of the present invention can be used for precise treatment of tumor blood vessels. Angiogenesis-related factors mainly include vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), transforming growth factor-β (Transforming growth factor-β; TGF-β), fibroblast growth factor Factor (Fibroblast growth factor; FGF), tumor necrosis fact...
Embodiment 3
[0097] The quantum dot sonosensitizer complex prepared in Example 2 was used to study the targeted sonodynamic therapy of 7 kinds of tumors.
[0098] 7 types of tumor cells: MDA-MB-231 (human breast cancer cells), SGC7901 (human gastric cancer cells), SKOV3 (human ovarian cancer cells), SGC996 (human gallbladder cancer cells), HCC827 (human non-small cell lung cancer cells) , PC3 (human prostate cancer cells), 8305C (human thyroid cancer cells).
[0099] Quantum dots are enriched in the tumor cytoplasm by means of co-incubation, and a large amount of singlet oxygen generated by quantum dots under ultrasonic irradiation can effectively kill tumor cells. Wherein, the dosage of the quantum dot-sound sensitizer complex is 30-100 μg / mL, specifically 50 μg / mL, and the irradiation time is 9 minutes.
[0100] The results show that a large amount of singlet oxygen generated by targeted quantum dots under ultrasonic irradiation promotes the oxidative stress of tumor cells, which in tur...
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