Unlock instant, AI-driven research and patent intelligence for your innovation.

Method and composition for identifying methamphetamine-related populations and application thereof

A methamphetamine and crowd technology, applied in the field of biomedical technology and forensic science, can solve the problems of low drug and its metabolites and limited sensitivity, and achieve the effect of long window period, high detection sensitivity and easy access

Active Publication Date: 2022-01-14
张聚 +1
View PDF6 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although hair samples have the advantages of stability and easy storage, the content of drugs and their metabolites is generally very low, while the content of biological impurities is high, which limits the sensitivity of sample detection

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method and composition for identifying methamphetamine-related populations and application thereof
  • Method and composition for identifying methamphetamine-related populations and application thereof
  • Method and composition for identifying methamphetamine-related populations and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0078] The present invention is used to discriminate the analysis procedure of methamphetamine drug-related crowd as follows figure 1 As shown, a total of 47 methamphetamine drug-related personnel who had been free from drugs for more than 3 months were recruited, as well as healthy volunteers (recruited from the local society, with no significant difference in age and sex composition and drug-related people, after urine testing and questionnaire collection ) 39 people were enrolled; by collecting stool samples for 16SrDNA sequencing, the structure information of the intestinal microbial flora was obtained. According to the hierarchical information of the basic data of the enrolled personnel, they are divided into a training set and a verification set. Among them, the training set includes 30 drug-related personnel and 30 healthy volunteers, and the verification set includes 17 drug-related personnel and 9 healthy volunteers. Through the analysis of the characteristics of the...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a method and a composition for identifying methylamphetamine-related populations and application thereof. The method comprises the following steps: acquiring information of intestinal flora in a to-be-detected sample of a subject; and judging whether the subject relates to sucking methamphetamine or not based on the abnormality of the intestinal flora. According to the method, a court auxiliary screening technical scheme which is long in sampling time window period, stable and sensitive is developed for methylamphetamine-related suspects, and accurate detection based on intestinal flora detection materials is achieved by researching the influence of taking methylamphetamine on the intestinal flora of the suspects. Besides, the prediction accuracy of the method is remarkably improved, and the sensitivity exceeds 90% when the specificity is 100%, so that the method has potential application value in a court auxiliary technology for discriminating methamphetamine-related persons.

Description

technical field [0001] The present invention relates to the fields of biomedical technology and forensic science, in particular to a detection method for screening methamphetamine drug-related personnel using intestinal microbial information, and in particular to a method, composition and method for identifying methamphetamine drug-related people. its application. Background technique [0002] Methamphetamine, also known as methamphetamine (N-methylamphetamine), chemical formula: C 6 h 5 CH 2 CH(CH 3 )NHCH 3 (N-methyl-1-phenylpropan-2-amine, N-methyl-α-methylphenethylamine), is a potent central nervous system stimulant. It is mainly used for drugs and less commonly for the treatment of attention deficit hyperactivity disorder and obesity. Its crystalline form is commonly known as methamphetamine, and it is also one of the main ingredients of "ecstasy". [0003] Methamphetamine is neurotoxic, and it has been confirmed that it can damage dopaminergic neurons and seroton...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6888C12Q1/689C12Q1/04C12N15/11G16B5/20G16B25/20G16B40/00G16B50/00
CPCC12Q1/6888C12Q1/689G16B5/20G16B25/20G16B40/00G16B50/00Y02A90/10
Inventor 张聚丁楠
Owner 张聚