Method for qualitatively screening and confirming 25 additives in Chinese patent medicine and health-care oral liquid

Abstract

The invention discloses a method for qualitatively screening and confirming 25 additives in Chinese patent medicines and health-care oral liquid. The method provided by the invention can be used for simultaneously screening and confirming eight synthetic pigments, eight preservatives and nine sweeteners in the Chinese patent medicine and the health-care oral liquid, has the characteristics of simplicity, rapidness, high sensitivity, good reproducibility and the like, can meet the screening and confirmation analysis requirements of the synthetic pigments, common preservatives and sweeteners in the Chinese patent medicine and the health-care oral liquid, can provide a practical technical means for detection of additives in the Chinese patent medicines and the oral liquid, and has an important value for monitoring the use conditions of the additives in the Chinese patent medicines and the health-care products.

Description

Technical field [0001] The present invention belongs to the field of pharmaceutical analysis, particularly to a method for qualitative screening and confirmatory oral medicine and health products in the 25 kinds of additives. Background technique [0002] In recent years, with the continuous improvement of the public on healthy living and health standards, as well as the vigorous development of Chinese medicine industry, market demand for Chinese crude drugs is also increasing, Chinese crude drugs for the prevention and control staining driven by economic interests adulteration obtain an unfair advantage, for the detection of Chinese herbal medicines reported in staining substances are common. Pieces of Chinese herbal medicines and staining commonly reported adulteration involving about dozens of varieties, and constantly updated trend in recent years, which many of Cordyceps sinensis, saffron, incense and other precious crude drugs, while the price is low and the ubiquitous herb...

AI Technical Summary

Problems solved by technology

[0003] In addition to dyeing adulterated compounds, food additives such as preservatives and sweeteners in Chinese patent medicines and health products may also be due to regulatory loopholes. Phenyl esters have limit requirements, but no relevant preservative determination methods have been established. There are neither limit requirements nor relevant determination methods for other preservatives and sweeteners. As a result, some illegal traders, driven by interests, , in order to improve the taste or avoid the risk of microorganisms exceeding the standard in product storage, use additives beyond the scope or limit

In response to this situation, there are currently literature reports on the detection methods of preservatives and sweeteners in Chinese patent medicines and health product oral liquids. The common method is liquid chromatography, but due to the matrix in Chinese patent medicines and health product oral liquids Complex, simple liquid phase analysis method is prone to false positive or false negative results, so it is also necessary to establish a more specific method for further screening or positive confirmation of samples

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