Application of choline chloride in relieving inflammatory bowel diseases

A technology for inflammatory bowel disease and choline chloride, applied in the field of biomedicine, can solve the problems of less research and unreported, and achieve the effect of low price

Pending Publication Date: 2022-01-28
NANFANG HOSPITAL OF SOUTHERN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the research on choline chloride, there are few studies on the effect on inflammation
Regarding its pharmacological activity, especially its use in the treatment of inflammatory bowel disease has not been reported so far

Method used

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  • Application of choline chloride in relieving inflammatory bowel diseases
  • Application of choline chloride in relieving inflammatory bowel diseases
  • Application of choline chloride in relieving inflammatory bowel diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Purified rat food containing 5.0 g / kg choline chloride was purchased from Dyets Company in the experiment, and the mice were free to eat and replaced every three days. The DSS used in the experiment was purchased from MP Biomedical Company of the United States, and was prepared into a 2.5% DSS solution with double distilled water. It was ready for use and replaced every two days.

[0025] Grouping of mice and establishment of experimental models

[0026] The mouse strain was 6-week-old wild-type C57BL / 6 male mice. After about a week of adaptive feeding, 24 mice were randomly divided into four groups, namely, normal control group, inflammatory bowel disease model group, hypercholine Diet group, other cholinergic molecules (nicotine) intervention group. 6 in each group above.

[0027] 1) Blank control group: normal drinking water for 9 days. Mice were treated on day 9;

[0028] 2) Inflammatory bowel disease model group: add 2.5% dextran sulfate sodium (DSS) to the dri...

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Abstract

The invention belongs to the technical field of biological medicines, and particularly relates to application of choline chloride in relieving inflammatory bowel diseases. According to the invention, choline chloride is adopted to relieve mouse inflammatory bowel diseases induced by DSS. In-vivo experiments prove that a choline chloride diet can remarkably improve the decrease of the weight of the mouse after the DSS induces colitis, remarkably reduce the increase of the disease index of the mouse, improve the change of the colon length of the mouse and reduce the colon pathology score of the mouse. All the above indexes show that choline chloride can effectively relieve the inflammatory bowel diseases.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to an application of choline chloride in alleviating inflammatory bowel disease. Background technique [0002] Inflammatory bowel disease (Inflammatory Bowel Disease, IBD), also known as enteritis, is a collective term for a group of intestinal non-specific inflammatory diseases involving the ileum, rectum, and colon. Inflammatory bowel disease includes ulcerative colitis and Crohn's disease, the pathogenesis of which has not been clarified, and the clinical cure rate is low. In addition, there are some colonic lesions that cannot be classified into these two categories, called indeterminate colitis, which are generally rare. [0003] In recent years, the incidence of inflammatory bowel disease has been on the rise, with an incidence rate of 0.5-23 / 100,000 people, and there is a trend of getting younger. At present, the main treatment methods are still symptomatic support, drug therapy,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/14A61P1/00A61P1/04
CPCA61K31/14A61P1/00A61P1/04
Inventor 黄冰孟琰李艺闻刘思德李爱民蒋文林莹林志昭庄康敏
Owner NANFANG HOSPITAL OF SOUTHERN MEDICAL UNIV
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