Check patentability & draft patents in minutes with Patsnap Eureka AI!

Natural compound with anti-pancreatic cancer activity as well as separation method and application thereof

A natural compound, pancreatic cancer technology, applied in the preparation of organic compounds, chemical instruments and methods, separation/purification of carboxylate, etc., can solve the problem of lack of drug specificity in drug resistance, and the overall effective rate of drugs is less than 20% And other issues

Active Publication Date: 2022-02-01
LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Drug therapy is one of the main means of pancreatic cancer treatment, but due to drug resistance and lack of drug specificity, the overall effective rate of drugs is less than 20%
However, there are no relevant reports on extracting anti-pancreatic cancer active substances from notopterygium

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Natural compound with anti-pancreatic cancer activity as well as separation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1: Separation processes of Compounds 7, 10, 13, 17, including include the following steps:

[0021] 10 kg of dry reactor and rhizome were extracted 3 times with 70% methanol room temperature, each time 7 days, the extract was combined, and evaporated to the nano-free flavor, gave 3 kg of total extract. After the total extract was dispersed, it was extracted with petroleum ether (60 ~ 90 ° C), ethyl acetate, n-butanol, to obtain petroleum ether phase, ethyl acetate phase, n-butanol phase, and aqueous phase;

[0022] Ethyl acetate phase (170 g) was separated by silica gel column chromatography, petroleum ether-acetone (50: 1 ~ 0: 1, v / v) gradient elution, sequentially obtained eight components FR.1-FR.8;

[0023]Component FR.3 (12.0 g) was chromatographed with a silica gel column, petroleum ether-ethyl acetate (20: 1 ~ 0: 1, v / v) gradient elution, 6 components FR.3-1 ~ FR.3-6. Wherefr.3-3 (5.3 g) was further separated by silica gel column, EtOAc EtOAc (EtOAc) EtOA...

Embodiment 2

[0032] Example 2, Compound 7, 10, 13, 17, 20 for preparing anti-pancreatic cancer drugs

[0033] At least one compound in compounds 7, 10, 13, 17, 20 is an active substance, and prepared into an internal preparation (such as capsules, tablets, granules, etc.) or injection according to pharmaceutically acceptable excipients and processes. Wait.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a natural compound with anti-pancreatic cancer activity, which is obtained from an ethyl acetate extraction phase of notopterygium root through a series of extraction and separation, and comprises a coumarin compound, three phenylpropanoid compounds and a lignin compound. An anti-pancreatic cancer activity experiment result shows that the compound has an obvious proliferation inhibition effect on pancreatic cancer CAPAN-2, CFPAC-1, PANC-1 and SW1990 cells, so that the compound can obviously inhibit proliferation of pancreatic cancer cells, has a potential anti-pancreatic cancer effect, and is expected to be used as an active component for preparing a medicine for treating pancreatic cancer.

Description

Technical field [0001] The present invention relates to a natural compound having anti-pancreatic cancer activity from natural plant qi and a separation method thereof, and also relates to the biological activity of the compound of the compound and the application of the active component in the preparation of anti-pancreatic cancer drugs. It belongs to the field of plant active ingredient separation and medical field. Background technique [0002] Pancreatic Cancer (PC) is called "king of cancer", with high invasiveness and fatality, is one of the most prognosis worst malignant tumors. In recent years, the incidence of pancreatic cancer in my country has been rising, and the death rate is only 10% of the top 10 of malignant tumors, and the 5-year survival rate is only 10%. About 80% -85% of patients with pancreatic cancer have no surgery or have been transferred, even if the patient can be removed, the prognosis is still very poor, and only 10% to 15% of patients obtained by surg...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07D493/04C07C69/734C07C67/48C07C67/58C07C67/56A61P35/00A61P1/18
CPCC07D493/04C07C69/734C07C67/48C07C67/58C07C67/56A61P35/00A61P1/18
Inventor 杨军丽桑春艳
Owner LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com