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Preparation method of sectional specimen based on lung of viral pneumonia patient

A lung and specimen technology, applied in the field of cross-sectional specimen preparation, can solve the problems of lack of infectious autopsy sample preparation methods, lack of standardized procedures for viral pneumonia lung specimens, etc., to achieve obvious protective effect and avoid infection

Pending Publication Date: 2022-02-18
SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is still a lack of standardized procedures to follow for viral pneumonia lung specimens due to the lack of safe infectious autopsy sample preparation methods
More importantly, the current research and diagnosis of viral pneumonia are mostly in the state of separating pathological morphology from clinical images, or only superficially corresponding to each other, lacking a research plan to deeply integrate the two

Method used

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  • Preparation method of sectional specimen based on lung of viral pneumonia patient
  • Preparation method of sectional specimen based on lung of viral pneumonia patient
  • Preparation method of sectional specimen based on lung of viral pneumonia patient

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preparation example Construction

[0091] The present invention provides a method for preparing a cross-sectional specimen based on the lungs of a patient with viral pneumonia. In a biosafety autopsy room, the corpse is placed in a splash-proof autopsy isolation device for processing, including the following steps:

[0092] 1) In the biosafety autopsy room, place the corpse in a splash-proof autopsy isolation device for processing, dissect out the lungs, soak the lungs in fixative solution and take them out to obtain lung samples;

[0093] 2) Saw and cut the titanium dioxide dye on the surface of the lung specimen obtained in step 1) on the surface of the lung specimen obtained in step 1) and then cut the line, and then freeze the lung specimen;

[0094] 3) sawing the frozen lung specimen in step 2) along the sawing line, and verifying it with CT scanning to obtain a cross-sectional specimen;

[0095] 4) The tomographic specimens obtained in step 3) are collected pathologically, cleaned, and glued, and then ima...

Embodiment 1

[0167] In a biosafety autopsy with negative pressure filtration that meets the operating requirements, the hair of the corpse of the patient with viral pneumonia was shaved, the dirt and oil stains on the skin of the corpse were removed, and after disinfection with 75% ethanol water solution, the corpse was anatomically wounded with a bandage. Posture is shaped.

[0168] Open the curtain door of the upper openable openable and closable structure on the side of the pollution source chamber of the anti-splash autopsy isolation device, put the body of the patient with viral pneumonia into the pollution source chamber, and close the curtain door. The operator puts his hand into the pollution source chamber through the operating gloves of the sealing interface on the first operation port and / or the second operation port, and performs pathological dissection on the corpse. First cut off the trachea of ​​the corpse of the patient with viral pneumonia, use the T-shaped incision method...

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Abstract

The invention provides a preparation method of a sectional specimen based on the lung of a viral pneumonia patient, a corpse is placed in an anti-splashing autopsy isolation device for treatment in a biosafety autopsy room, and the preparation method comprises the following steps of: 1) dissecting the corpse to take out the lung, soaking the lung in a stationary liquid, and taking out the lung to obtain a lung specimen; 2) performing horizontal cross section datum line positioning on titanium dioxide dye on the surface of the lung specimen by adopting a line snapping method, scribing a saw cutting line, and freezing the lung specimen; 3) sawing the frozen lung specimen along a sawing line, and performing verifying by CT scanning to obtain a sectional specimen; and 4) performing pathological sampling, cleaning and glue brushing on the sectional specimen, and then performing imaging treatment and sealing up. According to the preparation method of the sectional specimen based on the lung of the viral pneumonia patient, precious clinical pathological data are reserved for subsequent research on viral pneumonia, and unnecessary infection of operators in the preparation process is avoided.

Description

technical field [0001] The invention belongs to the field of medical biotechnology, and relates to a preparation method based on a cross-sectional specimen of the lungs of a patient with viral pneumonia, in particular to a method based on viral pneumonia (especially highly contagious pneumonia, such as novel coronavirus pneumonia, SARS, etc. ) method for preparing specimens for clinical diagnosis, scientific research and teaching of cross-section of patient's lung. Background technique [0002] Viral pneumonia, especially highly contagious viral pneumonia, has become an infectious disease that seriously threatens the health and life of the whole human being. In the future, viral pneumonia is likely to become a public health disease that has plagued human society for a long time. Therefore, it is necessary for us to preserve as many viral pneumonia case materials as possible, and fully study their imaging and pathological conditions, in order to lay a solid foundation for a ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B6/00G01N1/28G01N1/30G01N1/42G01N23/046G09B23/28
CPCA61B6/58G01N23/046G01N1/30G01N1/286G01N1/42G09B23/28G01N2001/2873
Inventor 戴顺东林清源龙满美郑海燕季赛燕崔俊祺张圆
Owner SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE