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Application of tanshinone IIA sulfonatesodium in preparation of medicine

A technology of sodium sulfonate and tanshinone, which is applied in the directions of drug combination, pharmaceutical formula, medical preparation containing active ingredients, etc., can solve problems such as single species

Pending Publication Date: 2022-02-22
SPH NO 1 BIOCHEM & PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved in the present invention is to overcome the single defect of existing LDH inhibitors, and provide the application of tanshinone IIA sulfonate sodium in the preparation of medicines

Method used

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  • Application of tanshinone IIA sulfonatesodium in preparation of medicine

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] 1. Trial grouping and intervention

[0023] Sham operation group (SHAM group): 10 rats

[0024] Experimental group (ligation of the left anterior descending coronary artery), a total of 80 rats (see: Gao E, KochWJ. A novel and efficient model of coronary artery ligation in them. Methods in Molecular Biology (Clifton, N.J. ).2013;1037:299-311):

[0025] (1) STS 20.8mg / kg / d: 20 pieces

[0026] (2) Normal saline group: 20 rats

[0027] Administration method: intraperitoneal injection of the required dose of drugs or normal saline 1 hour before ligation of the left anterior descending coronary artery; then intraperitoneal injection of corresponding doses of drugs every day.

[0028] 2. Experimental results

[0029] Sodium tanshinone IIA sulfonate (STS) can reduce the level of LDH

[0030] Blood was collected from the right ventricle at 12 hours (12h) and 3 days (3d) after myocardial infarction, and the myocardial enzyme lactate dehydrogenase (LDH) was detected. Clinic...

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Abstract

The invention discloses an application of tanshinone IIA sulfonate sodium in preparation of a medicine. Blood is taken from the right ventricle 12 hours and 3 days after myocardial infarction, and the myocardial enzyme lactic dehydrogenase is detected. After the tanshinone IIA sulfonate sodium is used, LDH level begins to decrease after myocardial infarction for 12 hours, myocardial cell necrosis or injury begins to decrease, and significant difference is achieved in 3 days, so that the tanshinone IIA sulfonate sodium can significantly inhibit LDH level in plasma, especially LDH increase caused by myocardial cell necrosis or injury. Therefore, the tanshinone IIA sulfonate sodium can effectively inhibit the LDH level in a mouse body, and can be used for preparing antiepileptic drugs.

Description

technical field [0001] The invention relates to the application of sodium tanshinone IIA sulfonate in the preparation of medicines. Background technique [0002] Epilepsy refers to persistent or secondary changes in the brain with epileptic seizures as the main manifestation, and can cause serious consequences in neurobiology, psychology, sociology, and cognitive function. The etiology of epilepsy is complex and diverse, including genetic factors, brain diseases, systemic or systemic diseases, etc. In 2010, it was first discovered that acute myocardial infarction can cause epilepsy (Liu Xiqiang, Li Li. A case of acute myocardial infarction first diagnosed with epilepsy [J]. Journal of Clinical Cardiovascular Diseases, 2010, 026(007): 559-559.). According to statistics in 2016, there are about 50 million epilepsy patients in the world, especially with the aging of the population, this number is still expanding. Epilepsy is usually controllable but difficult to cure. Even wi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/58A61P25/08A61P9/10
CPCA61K31/58A61P25/08A61P9/10
Inventor 姜红张宝丽于鹏刘明苏恩勇黄臻辉
Owner SPH NO 1 BIOCHEM & PHARMA CO LTD
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