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Application of nosiheptide to preparation of periodontitis treatment medicine

A treatment drug, nosiheptide technology, applied in the field of medicine, can solve the problems of inapplicability of oral administration and systemic injection administration, no report on the application of nosiheptide, low bioavailability, etc., to improve BV/TV, The effect of reducing Tb.Sp and promoting inflammation repair

Inactive Publication Date: 2021-12-10
SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Although nosiheptide has good antibacterial activity, it is not suitable for oral administration and systemic injection due to poor water solubility and low bioavailability, and has not been used in clinical practice.
[0006] But there is no report about the application of nosiheptide in the preparation of periodontitis treatment medicine

Method used

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  • Application of nosiheptide to preparation of periodontitis treatment medicine
  • Application of nosiheptide to preparation of periodontitis treatment medicine
  • Application of nosiheptide to preparation of periodontitis treatment medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0034] 1. Materials and Methods

[0035] 1.1 Drugs and reagents

[0036] Thiostrepton (TSR) (Shanghai Biide Technology Co., Ltd. batch number: ATC114);

[0037] Nosiheptide (NOS) (Shanghai Biide Technology Co., Ltd., batch number: BPW785);

[0038] β-cyclodextrin (Shanghai Beide Technology Co., Ltd. batch number: BGW567);

[0039] Minocycline hydrochloride ointment (Perio, Perio) (Sunstar INC. registration number: H20150106);

[0040] NF-kβELISA kit (USCN KIT INC batch number: SEB824Ra);

[0041] TNF-α kit (Hangzhou Lianke Biotechnology Co., Ltd. batch number: 70-EK981-96);

[0042] Disposable vacuum sampler (Guangzhou Yangpu Medical Technology Co., Ltd.);

[0043] Orthodontic ligature (diameter 0.2mm).

[0044] 1.2 Establishment of experimental rat periodontitis model

[0045]A total of 32 healthy Spraguedawley (SD) male rats, weighing between 200 g and 250 g, were included. Six rats were randomly selected as the normal control group (C0 group), and the remaining 26 r...

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Abstract

The invention relates to the technical field of medicines, in particular to an application of nosiheptide to preparation of a periodontitis treatment medicine. The application proves that the nosiheptide has a treatment effect on a rat periodontitis model, can effectively improve the bone volume fraction, reduces the separation degree of bone trabecula, promotes osteogenesis, increases bone mass, inhibits inflammatory factors NF-K beta and TNF-alpha, inhibits the inflammatory cell level in periodontium, promotes fibroblast generation, promotes periodontium inflammation repair, facilitates periodontitis treatment, and does not have the side effects of enabling users to generate anorexia and influencing growth. The experimental result has clinical significance, and a new scheme is provided for clinical treatment of periodontitis.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of nosiheptide in the preparation of medicines for treating periodontitis. Background technique [0002] As a common oral disease, periodontal disease is not only one of the main causes of tooth loss in adults, but also a major oral disease that endangers human teeth and health. In addition to clinical oral cleaning and tooth extraction, drug prophylaxis and antibacterial drug treatment are also key components. Commonly used metronidazole and tinidazole may cause side effects such as gastrointestinal reactions, dizziness and headache, and minocycline hydrochloride has no obvious short-term antibacterial effect, which affects clinical efficacy. The most serious thing is that the widespread use of conventional antibiotics leads to the emergence of drug-resistant strains and cross-resistant strains, making it difficult for existing drugs to obtain effective effects...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/05A61K9/06A61K47/40A61P1/02A61P31/04A61P19/08
CPCA61K38/05A61K9/06A61K47/40A61P1/02A61P31/04A61P19/08
Inventor 陶疆刘文沈诗慧陈单丹郭恒白雪冰汪健
Owner SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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