Application of Guanxin Danshen Compound Preparation in the Preparation of Drugs for Improving Ventricular Remodeling

A compound preparation and the technology of Guanxin Danshen are applied in the application field of Guanxin Danshen compound preparation in the preparation of medicines for improving heart-related diseases, so as to achieve the effects of improving the level of cardiac function, reducing the area and protecting myocardial tissue.

Active Publication Date: 2019-10-22
INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are currently no basic research and clinical application reports on the compound preparation and its single drugs Danshen, Panax notoginseng and balm oil to prevent or treat ventricular remodeling after coronary artery recanalization in STEMI

Method used

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  • Application of Guanxin Danshen Compound Preparation in the Preparation of Drugs for Improving Ventricular Remodeling
  • Application of Guanxin Danshen Compound Preparation in the Preparation of Drugs for Improving Ventricular Remodeling
  • Application of Guanxin Danshen Compound Preparation in the Preparation of Drugs for Improving Ventricular Remodeling

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1: Establishment of Animal Model of Ventricular Remodeling After Coronary Artery Recanalization in Acute ST-segment Elevation Myocardial Infarction

Embodiment 11

[0026] Example 1.1 Experimental Animals

[0027] 90 healthy adult male SD rats, SPF grade, weighing 300-330 g, were provided by Beijing Weitong Lihua Experimental Animal Technology Co., Ltd.

Embodiment 12

[0028] Embodiment 1.2 Experimental material and instrument

[0029] Sodium pentobarbital, normal saline, AD Instruments multiconductor physiological recorder, ALC-V8S small animal ventilator (Shanghai Alcott Biotechnology Co., Ltd.), surgical hand speed instrument quick follow sterilizer Germinator 500 (Harvard, USA) apparatus), animal warming blanket ALC-HTP (Shanghai Alcott Biotechnology Co., Ltd.), disposable intravenous infusion needle, medical sterile gauze, medical surgical scissors, medical tweezers, medical suture needle, medical knitting thread 6-0 , Absorbable surgical suture PGA were purchased from Shanghai Pudong Jinhuan Medical Supplies Co., Ltd.

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Abstract

The invention discloses an application of a Guanxin salvia miltiorrhiza compound preparation in preparing a medicine for improving ventricular remodeling. The Guanxin salvia miltiorrhiza compound preparation is composed of 200 g of salvia miltiorrhiza, 200 g of pseudo-ginseng and 1.75 mL of dalbergiae odoriferae oil. The application comprises that for ventricular remodeling generated after acute ST-segment elevation myocardial infarction (STEMI) coronary artery recanalization, the Guanxin salvia miltiorrhiza compound preparation can effectively reduce levels of aspartate aminotransferase (AST), lactate dehydrogenase (LDH) and creatine kinase isoenzyme (CKMB) after STEMI coronary artery recanalization, improves systolic functions, reduces the area of myocardial fibrosis, and plays a major role in effectively improving ventricular remodeling.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and in particular relates to the application of a compound preparation of coronary heart and salvia miltiorrhiza in the preparation of medicines for improving heart-related diseases. Background technique [0002] Coronary heart disease is the disease with the highest mortality rate among cardiovascular diseases, and its death toll has increased from 5.737 million in 1990 to 8.139 million in 2013. Among the many types of coronary heart disease, acute myocardial infarction is an important cause of sudden cardiac death, clinically manifested as severe chest pain, accompanied by elevated serum myocardial enzymes and progressive deterioration of electrocardiogram and hemodynamics ; The pathological feature is myocardial cell necrosis, which can be divided into coagulation type necrosis and / or contractile zone necrosis. Clinically, it is emphasized to classify according to whether the ST-se...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/537A61P9/10A61P9/00
Inventor 孙晓波邢小燕孙桂波邓雪红
Owner INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI
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