Metafecal metabolism marker as well as screening method and application thereof
A technology of metabolic markers and screening methods, which is applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of diagnosis and intervention time delay, and achieve the effect of reducing operation difficulty and avoiding pain
Pending Publication Date: 2022-03-11
LONGGANG DISTRICT CENT HOSPITAL OF SHENZHEN
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[0004] This application discloses a meconium metabolic marker and its screening method and application. Through the research, the correlation between the meconium metabolic marker and the occurrence of jaundice is found to provide reliable evidence for the early prediction of neonatal jaundice, so as to solve the existing The current jaundice diagnostic technology has the problem of delay in diagnosis and intervention
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[0071] This example provides a meconium metabolic marker for evaluating neonatal jaundice, the meconium metabolic marker includes valine, leucine, isoleucine, methionine and phenylalanine.
[0072] The screening method for the above-mentioned meconium metabolic markers comprises the following steps:
[0073] Sample collection: collect the meconium of the jaundice group and the control group respectively, the jaundice group is a newborn with jaundice, and the control group is a normal newborn;
[0074] Sample treatment: carry out pretreatment to the meconium to obtain a sample to be analyzed;
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The invention relates to a meconium metabolism marker and a screening method and application thereof, the meconium metabolism marker is used for evaluating neonatal jaundice, and the meconium metabolism marker comprises valine, leucine and isoleucine. The valine, the leucine and the isoleucine are closely related to the neonatal jaundice, and the occurrence of the neonatal jaundice can be reliably judged by detecting the metabolic markers. Therefore, whether the neonates are prone to jaundice or not can be judged at the first time only by detecting meconium excreted by the newly born neonates, relevant monitoring and intervention are carried out in time, judgment does not need to be carried out two or three days after the neonates are born, and early discovery, early intervention and early treatment are truly achieved.
Description
technical field [0001] The present application relates to the field of medical technology, in particular to a meconium metabolic marker, a screening method and application thereof. Background technique [0002] Neonatal jaundice is a relatively common disease, and its occurrence is mainly caused by the increase of serum bilirubin concentration caused by the disorder of bilirubin metabolism in the body. , such as bilirubin value exceeding the standard is also called hyperbilirubinemia. Severe hyperbilirubinemia can lead to bilirubin encephalopathy, which can lead to bilirubin encephalopathy and serious sequelae if not detected and treated in time. [0003] According to the characteristics of neonatal bilirubin metabolism, jaundice generally occurs 2 to 3 days after birth, and blood testing can further accurately determine the level of bilirubin. However, this will lead to a delay in the diagnosis of neonatal jaundice, and it will not be possible to detect and intervene in t...
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IPC IPC(8): G01N30/88
CPCG01N30/88G01N2030/8818
Inventor 曾淑娟丘惠娴王章星王明帮黄循斌唐细生史林东郭凯平刘婷
Owner LONGGANG DISTRICT CENT HOSPITAL OF SHENZHEN