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PTC (Positive Temperature Coefficient) prognosis marker, application thereof and construction method of PTC prognosis evaluation model

A construction method and biomarker technology, applied in the field of cancer prognosis assessment, can solve the problems of not being able to fully explain the pathophysiological process of thyroid cancer, and the lack of breakthrough progress in clinical diagnosis and treatment of thyroid cancer, so as to reduce the risk of recurrence, strengthen the Practical and Instructive Effects

Pending Publication Date: 2022-03-11
XIANGYA HOSPITAL CENT SOUTH UNIV
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Problems solved by technology

At present, genes related to PTC have been found, including BRAF, RAS, RET / PTC, etc., but they are not enough to fully explain the pathophysiological process of thyroid cancer development, recurrence and metastasis, and have not made breakthroughs in the clinical diagnosis and treatment of thyroid cancer

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  • PTC (Positive Temperature Coefficient) prognosis marker, application thereof and construction method of PTC prognosis evaluation model
  • PTC (Positive Temperature Coefficient) prognosis marker, application thereof and construction method of PTC prognosis evaluation model
  • PTC (Positive Temperature Coefficient) prognosis marker, application thereof and construction method of PTC prognosis evaluation model

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Embodiment Construction

[0017] In order to make the technical problems, technical solutions and advantages to be solved by the present invention clearer, the following will describe in detail in conjunction with specific embodiments.

[0018] The construction method of the prognosis evaluation model of PTC, the process is as follows figure 1 shown.

[0019] 1. Statistical analyzes were performed using the R package (http: / / www.r-project.org), all analyzes were performed in R version 3.3.2 using the following packages: 'glmnet', 'lpc', 'CoxBoost', ' Limma', 'pROC', 'rms'".

[0020] 2. Data acquisition: Download the clinical data of 501 patients with papillary thyroid carcinoma and the RNA of 501 thyroid cancer tissues and 58 normal thyroid tissues in the TCGA database from GDC Data Portal (https: / / portal.gdc.cancer.gov) -Seq transcriptome data, where RNA-Seq transcriptome data is displayed in the form of HT-seq count;

[0021] 3. Screening of differential lncRNAs: The R software "DESeq2" package wa...

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Abstract

The invention provides a PTC prognostic marker and application thereof, and a construction method of a PTC prognostic evaluation model. The positive temperature coefficient (PTC) prognosis biomarker comprises one or more of lncRNA (long non-coding RNA) related to m6A, wherein the lncRNA is selected from the group consisting of AC025175.1, CCDC13-AS1, AC093249.2, AL356481.1, AC008556.1, AC103957.2, AL049796.1 and AC012213.4, and the lncRNA is used for detecting the positive temperature coefficient (PTC). According to the invention, a PTC recurrence risk assessment model is constructed by m6A-related lncRNA for the first time, judgment is carried out based on the expression condition of risk genes of each patient, the recurrence risk of the patient can be predicted more accurately and individually, and a clinical decision can be better guided; by adopting a genomics method, the postoperative recurrence risk can be detected by taking a small amount of cancer tissue, more accurate formulation is carried out on selection of an operation scheme and subsequent treatment in time, and the postoperative recurrence risk of a patient is reduced.

Description

technical field [0001] The invention belongs to the technical field of cancer prognosis assessment, and relates to a PTC prognosis marker and its application, and a method for constructing a PTC prognosis assessment model. Background technique [0002] Thyroid cancer is the most common malignant tumor in the endocrine system, accounting for about 1.3% of systemic malignant tumors, of which thyroid papillary cancer (Thyroid papillary cancer, PTC) accounts for 80%-90% of thyroid malignant tumors. Although the malignancy of PTC is relatively low and the prognosis is generally good after treatment, about 20% of PTC patients still experience recurrence and metastasis. The quality of life of patients is even endangered, and it imposes financial and spiritual burdens on patients' families. Therefore, further in-depth study of the pathogenesis of PTC is of great significance to the diagnosis and treatment of the disease. How to diagnose these patients with poor prognosis as early ...

Claims

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Application Information

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IPC IPC(8): G16H50/30G16H50/70G16B20/00G16B40/00
CPCG16H50/30G16H50/70G16B20/00G16B40/00
Inventor 黄鹏常实欧阳登洁刘绵陈佩谭海龙吴敏赵雅鑫魏波
Owner XIANGYA HOSPITAL CENT SOUTH UNIV
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