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Ibuprofen controlled release tablet and preparation method thereof

A technology of controlled-release tablets and immediate-release tablets, which is applied in the field of medicine, can solve the problems of repeated administration to patients, unsustainable drug effect, and inability to achieve patient pain.

Pending Publication Date: 2022-03-15
OVERSEAS PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Immediate-release dosage forms release rapidly, but due to the short half-life of ibuprofen (t 1 / 2 About 2 hours), the drug is quickly eliminated in the body, so the drug effect cannot last, and the patient needs to take multiple doses
The currently commercially available sustained-release dosage forms can continue to take effect for a certain period of time, reduce the number of times of taking medicine, and improve patient compliance, but they cannot take effect quickly after taking the medicine, and cannot quickly reduce the pain of patients.

Method used

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  • Ibuprofen controlled release tablet and preparation method thereof
  • Ibuprofen controlled release tablet and preparation method thereof
  • Ibuprofen controlled release tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] Embodiment 1 prepares 1000 ibuprofen controlled-release tablets (excluding tablet core)

[0068] Taking the preparation of 1000 ibuprofen controlled-release tablets as an example, its components and dosage are as follows:

[0069]

[0070] The method for preparing ibuprofen controlled-release tablets in Example 1 of the present invention comprises the following steps:

[0071] a. Weigh 100.00g of ibuprofen and 96.20g of filler required for the preparation of the immediate-release layer, perform wet granulation with purified water or alcohol solution, pass the wet granulation through a 1000-8000μm sieve, dry, and dry granulate Pass through a 1000-8000μm sieve, add 18.81g of binder, 31.20g of disintegrant, and 2.50g of glidant, pre-mix, then add 1.32g of lubricant and mix to prepare immediate-release layer granules for later use;

[0072] b. Weigh 700.00g of ibuprofen, 362.51g of sustained-release polymer, and 327.03g of filler required for the preparation of the sust...

Embodiment 2

[0074] Embodiment 2 prepares 2000 ibuprofen controlled-release tablets (excluding tablet core)

[0075] Taking the preparation of 2000 ibuprofen controlled-release tablets as an example, its components and consumption are as follows:

[0076]

[0077] The method for preparing ibuprofen controlled-release tablets in Example 2 of the present invention comprises the following steps:

[0078]a. Weigh 300.00g of ibuprofen and 185.90g of filler required for the preparation of the immediate-release layer, perform wet granulation with purified water or alcohol solution, pass the wet granulation through a 1000-8000μm sieve, dry, and dry granulate Pass through a 1000-8000 μm sieve, add 44.88g of binder, 60.00g of disintegrant, and 6.12g of glidant, pre-mix, and then add 3.05g of lubricant and mix to prepare immediate-release layer granules for later use;

[0079] b. Weigh 1300.00g of ibuprofen, 471.00g of sustained-release polymer, and 164.50g of filler required for the preparation ...

Embodiment 3

[0081] Embodiment 3 prepares 800 ibuprofen controlled-release tablets (excluding tablet core)

[0082] Taking the preparation of 800 ibuprofen controlled-release tablets as an example, its components and consumption are as follows:

[0083]

[0084]

[0085] The method for preparing ibuprofen controlled-release tablets in Example 3 of the present invention comprises the following steps:

[0086] a. Weigh 160.00g of ibuprofen and 57.10g of filler required for the preparation of the immediate-release layer, perform wet granulation with purified water or alcohol solution, pass the wet granulation through a 1000-8000μm sieve, dry, and dry granulate Pass through a 1000-8000 μm sieve, add 19.50 g of binder, 19.50 g of disintegrating agent, and 2.60 g of glidant, pre-mix, then add 1.30 g of lubricant and mix to prepare immediate-release layer granules for later use;

[0087] b. Weigh 480.00g of ibuprofen, 143.90g of sustained-release polymer, and 55.00g of filler required for ...

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Abstract

The invention provides an ibuprofen controlled release tablet and a preparation method thereof, the controlled release tablet is composed of a drug-containing quick release layer and a drug-containing slow release layer, and the mass of ibuprofen in the drug-containing slow release layer is greater than that of ibuprofen in the drug-containing quick release layer. And the ratio of the mass of the ibuprofen in the drug-containing slow release layer to the mass of the ibuprofen in the drug-containing quick release layer is less than or equal to 7. After the tablet is taken, the effect of effectively relieving pain in 24 hours can be achieved.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an ibuprofen controlled-release tablet and a preparation method thereof. Background technique [0002] Ibuprofen has anti-inflammatory, analgesic and antipyretic effects, and is one of the most widely used analgesic, antipyretic and anti-inflammatory drugs. In 1969, it was first used to treat rheumatic and painful conditions. It is now used for the relief and treatment of: pain in non-severe arthritic conditions, rheumatism, muscle pain, back pain, neuralgia, headaches (including migraines), dental pain, dysmenorrhea, fever, cold and influenza symptoms. [0003] Pain is a huge global problem, estimated to affect approximately 20% of adults worldwide. Pain can cause a variety of serious problems for people, including but not limited to depression, inability to work, interruption of social relationships, suicidal thoughts, so pain can affect people's normal life. ...

Claims

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Application Information

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IPC IPC(8): A61K9/24A61K9/22A61K31/192A61K47/38A61K47/36A61K47/26A61K47/32A61P29/00
CPCA61K9/2095A61K9/209A61K9/205A61K9/2059A61K9/2054A61K9/2027A61K31/192A61P29/00A61K9/2009A61K9/2013
Inventor 闻晓光黄小锋赵大川范军张晨梁汪培培李敏
Owner OVERSEAS PHARMA