Preparation method and application of quasi-positive medicine X-333 with uric acid reducing and gout resisting effects

An anti-gout and uric acid-lowering technology, which is applied to medical preparations, applications, and pharmaceutical formulas containing active ingredients, can solve the problems of high cost of uric acid-lowering anti-gout drug trials, long clinical research cycles, and large human toxicity. Achieve the effect of enhancing national immunity, good effect, and obvious drug effect

Pending Publication Date: 2022-03-18
江苏德元佰晟健康科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are few edible medicines with anti-gout and uric acid-lowering effects developed so far, and the development of safe and efficient anti-gout and uric acid-lowering new drugs or foods is still an urgent need for the majority of patients.
[0004] The present invention aims to solve the problems of high test cost and long clinical research cycle for the preparation of uric acid-lowering anti-gout drugs by traditional methods, and the problems that existing uric acid-lowering curative drugs will cause serious adverse reactions after long-term use; the preparation of drugs has more toxic effects on human body than natural plants big security issue

Method used

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  • Preparation method and application of quasi-positive medicine X-333 with uric acid reducing and gout resisting effects
  • Preparation method and application of quasi-positive medicine X-333 with uric acid reducing and gout resisting effects
  • Preparation method and application of quasi-positive medicine X-333 with uric acid reducing and gout resisting effects

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A preparation method of pseudopositive drug No. 1 with uric acid-lowering and anti-gout effects of the present invention, comprising the following steps:

[0024] (1) Weigh 3-5g CMC-Na, add 60-100mL water to boil to dissolve completely, transfer to 300-500ML volumetric flask after cooling to room temperature, and dilute to the maximum mark with pure water;

[0025] (2) Preparation of hypoxanthine: Weigh 0.5-1g hypoxanthine and dissolve in 10-20mL CMC-Na solution;

[0026] (3) Preparation of benzbromarone: weigh 0.05-0.1 g of benzbromarone and dissolve in 100-200 mL of CMC-Na solution;

[0027] (4) Preparation of the Spartina pratense extract solution: weigh the Spartina pratense extract (0.5-1 g), and prepare a 3-4.5 g / L solution with the above-mentioned CMC-Na solution;

[0028] (5) Preparation of pseudopositive drug No. 1: Weigh 0.5-1 g of the formula of pseudopositive drug No. 1, and prepare a 3-4.5 g / L solution with the above-mentioned CMC-Na solution.

[0029] Th...

Embodiment 2

[0058]A preparation method of the pseudopositive drug No. 2 with uric acid-lowering and anti-gout effects of the present invention, comprising the following steps:

[0059] (1) Weigh 3-5g CMC-Na, add 60-100mL water to boil to dissolve completely, transfer to 300-500ML volumetric flask after cooling to room temperature, and dilute to the maximum mark with pure water;

[0060] (2) Preparation of hypoxanthine: Weigh 0.5-1g hypoxanthine and dissolve in 10-20mL CMC-Na solution;

[0061] (3) Preparation of benzbromarone: Weigh 0.05-0.1g benzbromarone and dissolve in 100-200mL CMC-Na solution;

[0062] (4) Preparation of licorice extract solution: take licorice extract (0.5-1g), and use the above CMC-Na solution to prepare a 3-4.5g / L solution;

[0063] (5) Preparation of pseudopositive drug No. 2: Weigh 0.5-1 g of the formula of pseudopositive drug No. 2, and prepare a 3-4.5 g / L solution with the above-mentioned CMC-Na solution.

[0064] The No. 2 pseudopositive drug consists of th...

Embodiment 3

[0090] A preparation method of the pseudopositive drug X-333 having the effect of lowering uric acid and anti-gout of the present invention comprises the following steps:

[0091] (1) Weigh 3-5g CMC-Na, add 60-100mL water to boil to dissolve completely, transfer to 300-500ML volumetric flask after cooling to room temperature, and dilute to the maximum mark with pure water;

[0092] (2) Preparation of hypoxanthine: Weigh 0.5-1g hypoxanthine and dissolve in 10-20mL CMC-Na solution;

[0093] (3) Preparation of benzbromarone: weigh 0.05-0.1 g of benzbromarone and dissolve in 100-200 mL of CMC-Na solution;

[0094] (4) Preparation of the Spartina pratense extract solution: weigh the Spartina pratense extract (0.5-1 g), and prepare a 3-4.5 g / L solution with the above-mentioned CMC-Na solution;

[0095] (5) Preparation of licorice extract solution: weigh licorice extract (0.5-1 g), and prepare a 3-4.5 g / L solution with the above-mentioned CMC-Na solution;

[0096] (5) Preparation o...

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Abstract

The invention discloses a preparation method and application of a pseudo-positive drug X-333 with uric acid reducing and gout resisting effects, and the preparation method of the pseudo-positive drug X-333 with the uric acid reducing and gout resisting effects comprises the following steps: (1) weighing gCMC-Na, adding water to boil to completely dissolve the gCMC-Na, cooling to room temperature, transferring into a volumetric flask, and measuring the content of the gCMC-Na in the volumetric flask; diluting with purified water to the maximum scale line; (2) preparing hypoxanthine: weighing xanthine, and dissolving the xanthine in a CMC-Na solution; (3) preparation of benzbromarone: weighing 0.05 to 0.1 g of benzbromarone, and dissolving the benzbromarone in the CMC-Na solution; (4) preparing a spartina parviflora extract solution; (5) preparing a licorice extract solution; and (5) preparing the quasi-positive medicine X-333, so as to prepare a solid product of the quasi-positive medicine X-333. The medicine is high in safety and obvious in medicine effect, and the medicine prepared according to the formula can be taken for a long time.

Description

technical field [0001] The invention relates to the technical field of research and development of new formulations for reducing uric acid, in particular to a preparation method and application of a pseudopositive drug X-333 with the effect of reducing uric acid and anti-gout. Background technique [0002] With the development of my country's economy, people's living standards have improved, but at the same time, due to excessive intake of high-fat, high-cholesterol and other ingredients and unhealthy lifestyles, the body's immunity has declined and diseases such as hyperuricemia and gout Frequent outbreaks threaten national health. According to research and statistics, the number of patients with hyperuricemia in my country is close to 170 million, and the incidence rate has reached 13.3%, and it continues to rise. The most important cause of gout—hyperuricemia (HUA) has become an The "fourth highest" after hyperlipidemia, in China, presents a trend of high prevalence, young...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A23L33/10A23L33/105A61P19/06A61P37/04A61P39/00A61P1/16A61P13/12A61K31/343A61K31/522
CPCA61K31/522A61K31/343A61K36/70A61K36/8945A61K36/484A61K36/899A61K36/605A61K36/488A61K36/42A61K9/19A61P19/06A61P37/04A61P39/00A61P1/16A61P13/12A23L33/105A23L33/10A23V2002/00A61K2300/00A23V2200/30A23V2200/324A23V2250/21
Inventor 马燕妮刘雅妮
Owner 江苏德元佰晟健康科技发展有限公司
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