Thermosetting hydroxypropyl methylcellulose hollow capsule and preparation method thereof

Abstract

The invention discloses a thermoset hydroxypropyl methylcellulose hollow capsule and a preparation method thereof. The thermoset hydroxypropyl methylcellulose hollow capsule is prepared from the following components in parts by weight: 90 to 120 parts of hydroxypropyl methylcellulose, 10 to 15 parts of trehalose, 0.5 to 0.6 part of sodium chloride and 50 to 450 parts of water. According to an existing production process, the problems of cracking and wrinkling are solved mainly by increasing the relative humidity in a dry environment to be larger than 80%, energy consumption is large, by means of the method, the relative humidity in the dry environment does not need to be increased, the relative humidity is only maintained to be 55%-75%, and energy consumption can be reduced; and meanwhile, the problems of cracking and wrinkling in batch production of the heat-setting hydroxypropyl methylcellulose hollow capsules can be solved.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a thermosetting hypromellose hollow capsule and a preparation method thereof. Background technique [0002] It is mentioned in the patent CN110051641A that hypromellose hollow capsules manufactured by thermal coagulation method, without adding a coagulant aid, only utilize the thermal coagulation characteristics of the hypromellose material, and use a high temperature mold for the capsule manufacture. In mass production, high temperature molds at 100-120°C are used to manufacture capsules. Due to the fast drying rate, there will be a large number of cracking and wrinkle defects in the capsules, as high as more than 95%. [0003] According to research and development experience in the capsule industry, adding moisturizing ingredients to capsules may reduce cracking and wrinkling defects. After trying various moisturizers, no effective results were obtained. So I began to sea...

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Problems solved by technology

After trying multiple moisturizers with no effective results

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