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Immunochromatography test strip and detection card for echinococcosis antibody

An immunochromatography test paper and immunochromatography technology, applied in measuring devices, analytical materials, biological testing, etc., can solve problems such as large differences between reagent batches, poor diagnostic specificity and stability, and easy missed detection. Achieve the effects of improving diagnostic efficiency and standardization, facilitating detection operations, and easy interpretation of results

Pending Publication Date: 2022-04-01
中国疾病预防控制中心寄生虫病预防控制所国家热带病研究中心
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, most of the echinococcosis antibody diagnostic reagents sold in the market use natural parasite antigens. The acquisition of natural materials is not convenient, and it is difficult to standardize, resulting in large differences between batches of reagents, and it is different from cysticercosis, etc. Other parasitic diseases have high cross-reactivity, poor diagnostic specificity and stability
Some studies have tried to use recombinant antigens to replace natural antigens, but the detection sensitivity is often low, because only a single antigen is used for detection in the detection, resulting in poor detection sensitivity and easy missed detection
Therefore, these reported recombinant antigens cannot be practically used in the detection of echinococcosis; or they must be combined with natural antigens for detection

Method used

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  • Immunochromatography test strip and detection card for echinococcosis antibody
  • Immunochromatography test strip and detection card for echinococcosis antibody
  • Immunochromatography test strip and detection card for echinococcosis antibody

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Example 1 Echinococcus antibody immunochromatographic test strip

[0041] figure 1 with 2 A specific embodiment of the hydatid antibody immunochromatographic test strip of the present invention is shown. In this embodiment, the hydatid antibody immunochromatographic test strip includes a bottom plate 6 and successive ends overlapped and connected on the bottom plate Sample pad 4 on 6, gold standard pad 7, nitrocellulose membrane 3, absorbent pad 5. Wherein the two ends of the nitrocellulose membrane 3 are all arranged in the position close to the base plate 6 in the overlapping connection, that is, one end of the gold standard pad 7 and one end of the water-absorbing pad 5 are respectively pressed on the two ends of the nitrocellulose membrane 3 (such as figure 1 shown).

[0042] The gold standard pad 7 is a glass fiber membrane on which colloidal gold-labeled Streptococcus protein G or colloidal gold-labeled Staphylococcus aureus protein A is immobilized.

[0043] ...

Embodiment 2

[0052] Example 2 Echinococcus antibody immunochromatography detection card

[0053] Figure 3-6 A specific embodiment of the present invention is shown. In this embodiment, the Echinococcus antibody immunochromatographic detection card includes a casing 2 and a test strip 1 . The housing 2 comprises a first end 21 and a second end 22 . Between the first end portion 21 and the second end portion 22, the housing 2 is sequentially provided with: a raised point area 20 for holding the immunochromatographic detection device; a registration recording area 19 for recording information, the The information includes sample information, test date and test result; the observation window 12 is used to observe the immunochromatography of the test strip 1 arranged in the housing 2; the sample injection hole 13 is used to add a sample to the on the test strip 1 inside.

[0054] The raised point area 20 is located at the upper left corner of the upper surface of the casing 2 and is in the ...

Embodiment 3

[0061] In this embodiment, the number of positioning posts on the side of the test strip is 4, which are divided into 2 rows and arranged on both sides of the test strip positioning plate. The number of the clamping positioning holes and the clamping positioning posts are the same, both being four. All the other are the same with embodiment 2.

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Abstract

The invention discloses an echinococcosis antibody immunochromatography test strip and a detection card. The test strip comprises a nitrocellulose membrane, a detection line group and a quality control line are arranged on the nitrocellulose membrane; the detection line group comprises a T1 detection line, a T2 detection line and a T3 detection line which are respectively coated with different recombinant echinococcosis antigens; the result judgment rule is as follows: (1) if the quality control line and any two or more detection lines are colored, the judgment result is positive; (2) if the quality control line develops the color and the detection line does not develop the color, or the quality control line develops the color and only one detection line develops the color, the judgment result is negative; and (3) the quality control line does not develop color, and no matter whether the detection line develops color, the echinococcosis antibody immunochromatography test strip is invalid, and detection should be carried out again. The detection card comprises a shell and the test strip, a registration recording area, an observation window and a sample adding hole are sequentially formed in the shell. The echinococcosis detection device is high in echinococcosis detection accuracy, simple and reasonable in structure and convenient to independently package and store for a long time.

Description

technical field [0001] The invention relates to a medical detection device, in particular to an echinococcosis antibody immunochromatographic test strip and a detection card. Background technique [0002] Echinococcosis (also called echinococcosis) is a serious zoonotic parasitic disease caused by Echinococcus and its larvae (Echinococcus) parasitizing in humans and animals. Among the currently known echinococcosis, the most serious harm to human body and social economy is Cystic echinococcosis (CE) and Alveolarechinococcosis (AE). The disease is highly prevalent in the Qinghai-Tibet Plateau region of my country, and it is a parasitic disease that the country focuses on prevention and control. In endemic areas, there are generally problems of underdeveloped economy, harsh natural conditions, inconvenient transportation, high work costs, and lack of health professional and technical personnel. It is urgent to improve the technical level and work efficiency of prevention and...

Claims

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Application Information

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IPC IPC(8): G01N33/558G01N33/68
Inventor 张颋莫筱瑾胡薇周晓农庞华胜李景中
Owner 中国疾病预防控制中心寄生虫病预防控制所国家热带病研究中心